AbbVie (ABBV), Enanta (ENTA) Active Following Gilead's (GILD) HCV Treatment Update
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Gilead Sciences (GILD) Reports Topline Results from SOF + LDV Phase 3s
December 18, 2013 8:47 AM ESTGilead Sciences, Inc. (Nasdaq: GILD) announced topline results from three Phase 3 clinical trials (ION-1, ION-2 and ION-3) evaluating the investigational once-daily fixed-dose combination of the nucleotide analog polymerase inhibitor sofosbuvir (SOF) 400 mg and the NS5A inhibitor ledipasvir (LDV) 90 mg, with and without ribavirin (RBV), for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection.
Across the three studies, 1,952 patients with genotype 1 HCV infection were randomized to receive SOF/LDV with or without RBV for eight, 12 or 24 weeks of therapy. Of these, 1,512 patients were treatment-naïve, 440 were treatment experienced and 224 had compensated... More
