Needham & Company 2012 Biotech Preview

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Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) Delayed: 303.64 +11.06 (3.78%)
Previous Close $292.58    52 Week High $109.10 
Open $297.22    52 Week Low $31.38 
Day High $310.53    P/E N/A 
Day Low $293.85    EPS $-1.45 
Volume 1,081,496       

Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) Delayed: 101.94 --0 (-0%)
Previous Close $101.94    52 Week High $101.99 
Open $3.23    52 Week Low $58.50 
Day High $101.94    P/E N/A 
Day Low $101.94    EPS $-0.27 
Volume 3,714       

Dendreon Corp (NASDAQ: DNDN) Delayed: 0.13 --0 (-0%)
Previous Close $0.13    52 Week High $3.46 
Open $11.75    52 Week Low $0.11 
Day High $0.13    P/E N/A 
Day Low $0.13    EPS $-1.63 
Volume 279       

Gilead Sciences (NASDAQ: GILD) Delayed: 129.18 +0.19 (0.15%)
Previous Close $128.99    52 Week High $108.63 
Open $130.57    52 Week Low $71.39 
Day High $131.04    P/E 71.37 
Day Low $128.01    EPS $1.81 
Volume 13,729,158       

Human Genome Sciences, Inc. (NASDAQ: HGSI) Delayed: 14.24 --0 (-0%)
Previous Close $14.24    52 Week High $16.58 
Open $55.80    52 Week Low $6.51 
Day High $14.24    P/E N/A 
Day Low $14.24    EPS $-1.79 
Volume 557,147       

Johnson & Johnson (NYSE: JNJ) Delayed: 228.17 +4.93 (2.21%)
Previous Close $223.24    52 Week High $126.07 
Open $227.09    52 Week Low $94.28 
Day High $228.67    P/E 47.44 
Day Low $225.90    EPS $4.81 
Volume 7,274,160       

Lexicon Pharmaceuticals, Inc. (NASDAQ: LXRX) Delayed: 1.90 +0.05 (2.70%)
Previous Close $1.85    52 Week High $19.62 
Open $1.84    52 Week Low $7.65 
Day High $1.99    P/E N/A 
Day Low $1.84    EPS $-0.22 
Volume 1,756,835       

Micromet, Inc. (AMEX: MITI) Delayed: 0.09 +0.01 (12.50%)
Previous Close $0.08    52 Week High $11.00 
Open $0.09    52 Week Low $4.13 
Day High $0.09    P/E N/A 
Day Low $0.08    EPS $-0.81 
Volume 12,403       

Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR) Delayed: 12.78 --0 (-0%)
Previous Close $12.78    52 Week High $16.80 
Open $12.78    52 Week Low $8.64 
Day High $12.78    P/E N/A 
Day Low $12.78    EPS $-1.75 
Volume 1,179,540       

Pharmacyclics, Inc. (NASDAQ: PCYC) Delayed: 261.25 --0 (-0%)
Previous Close $261.25    52 Week High $261.68 
Open $0.82    52 Week Low $85.50 
Day High $261.25    P/E 300.29 
Day Low $261.25    EPS $0.87 
Volume 3,226       

Seattle Genetics Inc /wa (NASDAQ: SGEN) Delayed: 228.74 --0 (-0%)
Previous Close $228.74    52 Week High $75.36 
Open $22.94    52 Week Low $26.02 
Day High $228.74    P/E N/A 
Day Low $228.74    EPS $-0.51 
Volume 759,302       

Targacept, Inc. (NASDAQ: TRGT) Delayed: 0.96 --0 (-0%)
Previous Close $0.96    52 Week High $3.23 
Open $0.01    52 Week Low $0.82 
Day High $0.96    P/E N/A 
Day Low $0.96    EPS $-1.39 
Volume 3,200       

Vertex Pharmaceuticals Inc (NASDAQ: VRTX) Delayed: 441.74 +13.40 (3.13%)
Previous Close $428.34    52 Week High $134.71 
Open $434.95    52 Week Low $73.31 
Day High $448.19    P/E N/A 
Day Low $433.50    EPS $-1.98 
Volume 1,362,387       

Pharmasset, Inc. (AMEX: VRUS) Delayed: 0.00 --0 (-0%)
Previous Close $0.00    52 Week High $137.81 
Open $67.86    52 Week Low $46.49 
Day High $0.00    P/E 0.00 
Day Low $0.00    EPS $-1.25 
Volume 34,954