Kura Oncology reports Phase 1a data on darlifarnib combo in RCC
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Kura Oncology Reports Durable Clinical Activity of Darlifarnib Plus Cabozantinib in Cabozantinib-Naïve Clear Cell Renal Cell Carcinoma Patients at KCRS 2026
July 27, 2026 6:32 AM EDTResponse rates up to 50% across evaluated dose levels and median PFS of 13 months observed in pre-treated, cabozantinib-naïve, locally advanced or metastatic ccRCC patients
Activity compares favorably with historical outcomes for TKI and HIF-2 monotherapies -
Combination was well tolerated and safety profile consistent with reported profiles of the individual agents
Findings support potential for darlifarnib to enhance activity of VEGFR-targeted therapies in second- and third-line RCC settings
Global, randomized Phase 1b study underway to establish recommended Phase 3 dose
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