AstraZeneca reports positive SERENA-6 trial results for camizestrant

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Camizestrant Combination Delayed Time to First Progression by 55% and to Second Progression by 37% in Patients With Advanced HR-positive Breast Cancer With an Emergent ESR1 Tumor Mutation in SERENA-6

June 2, 2026 8:00 AM EDT

Switching to camizestrant led to a 99% median reduction in total ctDNA vs. a 64% increase for patients who remained on standard of care

51% of patients receiving the camizestrant combination achieved total ctDNA clearance vs. 1.9% with standard of care early total ctDNA clearance was associated with an improvement in long-term outcome

WILMINGTON, Del.--(BUSINESS WIRE)-- Further positive... More