Praxis pauses vormatrigine study after trial misses primary endpoint
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Praxis Precision Medicines Provides Vormatrigine Program Update
June 1, 2026 4:15 PM EDTPOWER1 Study in highly refractory patients with focal onset seizures did not meet its primary success measure
Secondary measure, the 50% response rate, was met and seizure reduction during the second half of the study on higher dose (30 mg) was more pronounced
Vormatrigine was generally well-tolerated; adverse event-related discontinuations were less than 10%
Approximately 90% of patients from the vormatrigine arm transitioned to and remain in the open label extension (OLE) study
Praxis is pausing enrollment in the POWER2 study to reassess the vormatrigine program and... More

