Fulcrum Therapeutics discontinues pociredir program, begins strategic review

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Fulcrum Therapeutics Announces Discontinuation of Pociredir Program in Sickle Cell Disease and Initiation of Strategic Review

June 1, 2026 4:05 PM EDT

Decision follows FDA feedback regarding the implications of the secondary malignancies observed with Tazverik® (tazemetostat) and the products subsequent global withdrawal on the benefit-risk profile of pociredir in sickle cell disease (SCD)

Company to explore strategic alternatives to maximize stockholder value

CAMBRIDGE, Mass., June 01, 2026 (GLOBE NEWSWIRE) -- Fulcrum Therapeutics, Inc.® (Fulcrum) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with rare hematological disorders, today announced the discontinuation of its pociredir program... More