InflaRx shows lower reactive metabolite formation for izicopan vs avacopan

Go back to InflaRx shows lower reactive metabolite formation for izicopan vs avacopan

InflaRx Reports Favorable Reactive Metabolite Profile for Izicopan in Human Liver Microsomes

May 4, 2026 7:30 AM EDT

JENA, Germany, May 04, 2026 (GLOBE NEWSWIRE) -- InflaRx N.V. (Nasdaq: IFRX), a biopharmaceutical company pioneering anti-inflammatory therapeutics by targeting the complement system, today announced new pre-clinical data demonstrating low reactive metabolite formation of izicopan in human liver microsomes. Reactive metabolite formation is widely used in drug development as an early mechanistic indicator of potential bioactivation-related safety risk.

Izicopan is an investigational next-generation oral C5aR1 inhibitor designed to achieve differentiated pharmacological properties, with the potential for improved efficacy and safety. The marketed comparator, avacopan, is a first-in-class... More