AstraZeneca drug meets goals in two COPD trials
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Tozorakimab met primary endpoint in both OBERON and TITANIA Phase III trials in patients with COPD
March 27, 2026 7:00 AM EDTFirst-ever IL-33-targeting biologic to demonstrate statistically significant and highly clinically meaningful reductions in COPD exacerbations in two replicate Phase III clinical trials
WILMINGTON, Del.--(BUSINESS WIRE)-- Positive high-level results from the Phase III OBERON and TITANIA trials in patients with chronic obstructive pulmonary disease (COPD) showed that tozorakimab reduced the annualized rate of moderate-to-severe COPD exacerbations compared with placebo, in the primary population of former smokers, and in the overall population, which included former and current smokers, and patients across all blood eosinophil* counts and all stages of lung function severity.... More
