Prothena presents TDP-43 data at neuroscience conference

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Go back to Prothena presents TDP-43 data at neuroscience conference

Prothena Announces Poster Presentation on its TDP-43 CYTOPE® Program at Neuroscience 2025

November 19, 2025 4:05 PM EST

TDP-43 CYTOPE® preclinical data demonstrates the potential of Prothenas CYTOPE technology as a novel modality for delivering large molecules into cells, enabling precise targeting of intracellular disease pathways Systemically-administered TDP-43 CYTOPE rapidly and efficiently distributed to the brain and periphery, internalized into the cytosol and significantly reduced intracellular TDP-43 pathology in an ALS mouse model TDP-43 CYTOPE meaningfully reduced intracellular TDP-43 pathology and associated RNA dysregulation caused by cryptic exon inclusions - key pathogenic features of TDP-43 proteinopathies - in a human-derived neuronal cell line

 

DUBLIN, Ireland--(BUSINESS WIRE)-- Prothena... More