Precigen Inc. (PGEN) Presents Preclinical Data

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Go back to Precigen Inc. (PGEN) Presents Preclinical Data

Precigen Presents Preclinical Data for the Next Generation Mesothelin UltraCAR-T® with Intrinsic PD-1 Blockade at the AACR Annual Meeting 2023

April 17, 2023 9:01 AM EDT

First preclinical data presented for the next generation of the UltraCAR-T platform utilizing a mesothelin (MSLN) chimeric antigen receptor (CAR)

MSLN is overexpressed on multiple solid tumors such as mesothelioma, ovarian cancer and pancreatic cancer

Proprietary technology for checkpoint blockade intrinsic to UltraCAR-T cells has the potential for an improved safety profile and reduced cost by eliminating the need for checkpoint inhibitor combination 

Single administration of next generation MSLN UltraCAR-T incorporating intrinsic PD-1 blockade resulted in robust UltraCAR-T cell expansion and durable persistence leading to... More