Notable Holders of (AFMD)
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* Does Not Fully Represent All Holders
| Fund | Title | Shares | % Owned | Source |
|---|---|---|---|---|
| 683 Capital Management, LLC | COM | 9,000,000 | N/A | 13F |
| BAKER BROS ADVISORS LLC | COM | 6,596,830 | N/A | 13F |
| NEA Management Company, LLC | COM | 4,426,488 | N/A | 13F |
| Citadel | COM | 3,886,673 | N/A | 13F |
| MILLENNIUM MANAGEMENT LLC | COM | 3,177,455 | N/A | 13F |
| Eversept Partners, LLC | COM | 1,676,684 | N/A | 13F |
| Fidelity Investments | COM | 1,449,684 | N/A | 13F |
| VR Adviser, LLC | COM | 1,428,571 | N/A | 13F |
| VANGUARD GROUP INC | COM | 1,410,249 | N/A | 13F |
| PICTET ASSET MANAGEMENT LTD | COM | 1,009,299 | N/A | 13F |
| Fisher Asset Management, LLC | COM | 895,217 | N/A | 13F |
| TWO SIGMA INVESTMENTS LLC | COM | 841,568 | N/A | 13F |
| Verition Fund Management LLC | COM | 778,200 | N/A | 13F |
| TWO SIGMA ADVISERS, LLC | COM | 665,670 | N/A | 13F |
| RENAISSANCE TECHNOLOGIES LLC | COM | 589,597 | N/A | 13F |
| Hambrecht & Quist Capital Management LLC | Common | 586,038 | N/A | 13F |
| STATE STREET CORP | COM | 529,362 | N/A | 13F |
| BNP PARIBAS ARBITRAGE, SA | Equity | 519,497 | N/A | 13F |
| Intellectus Partners, LLC | COM | 418,790 | N/A | 13F |
| Nan Fung Group Holdings Ltd | COM | 372,472 | N/A | 13F |
| Alyeska Investment Group, L.P. | COM | 350,000 | N/A | 13F |
| UBS OCONNOR LLC | COM | 340,900 | N/A | 13F |
| ACT CAPITAL MANAGEMENT, LLC | COM | 308,800 | N/A | 13F |
| D. E. Shaw & Co., INC. | COM | 255,159 | N/A | 13F |
| Y-Intercept (Hong Kong) Ltd | COM | 215,586 | N/A | 13F |
| Qube Research & Technologies Ltd | COM | 215,463 | N/A | 13F |
| ACADIAN ASSET MANAGEMENT LLC | COM | 213,467 | N/A | 13F |
| Telemetry Investments, L.L.C. | COM | 200,000 | N/A | 13F |
| PARAMETRIC PORTFOLIO ASSOCIATES | Common Stock | 187,778 | N/A | 13F |
| Ergoteles LLC | COM | 141,300 | N/A | 13F |
| WELLS FARGO & CO/MN | COM | 139,514 | N/A | 13F |
| GEODE CAPITAL MANAGEMENT LLC | COM | 135,947 | N/A | 13F |
| JANE STREET GROUP, LLC | COM | 129,807 | N/A | 13F |
| KENNEDY CAPITAL MANAGEMENT INC | COM | 121,787 | N/A | 13F |
| DIMENSIONAL FUND ADVISORS LP | COM | 113,702 | N/A | 13F |
| Susquehanna International Group, LLP | COM | 100,627 | N/A | 13F |
| BROWN ADVISORY HOLDINGS INC | COM | 90,000 | N/A | 13F |
| Laurion Capital Management LP | COM | 83,222 | N/A | 13F |
| TWO SIGMA SECURITIES, LLC | COM | 75,183 | N/A | 13F |
| BARCLAYS PLC | COM | 75,169 | N/A | 13F |
| HARBOR INVESTMENT ADVISORY, LLC | Stock | 62,200 | N/A | 13F |
| COMMONWEALTH EQUITY SERVICES, LLC. | COM | 58,696 | N/A | 13F |
| Schonfeld Strategic Advisors LLC | COM | 52,400 | N/A | 13F |
| LMR Partners LLP | COM | 51,361 | N/A | 13F |
| LPL Financial LLC | COM | 42,575 | N/A | 13F |
| Invesco Ltd. | COM | 42,065 | N/A | 13F |
| BALYASNY ASSET MANAGEMENT LLC | COM | 33,541 | N/A | 13F |
| Jump Trading, LLC | Common Stock | 31,700 | N/A | 13F |
| Goldman Sachs Asset Management, L.P. | CMN | 27,278 | N/A | 13F |
| Cresset Asset Management, LLC | COM | 26,762 | N/A | 13F |
| US BANCORP \DE\ | COM | 24,000 | N/A | 13F |
| Point72 Middle East FZE | COM | 23,943 | N/A | 13F |
| Tower Research Capital LLC | COM | 20,825 | N/A | 13F |
| Amalgamated Financial Corp. | COM | 18,899 | N/A | 13F |
| Vident Investment Advisory, LLC | COM | 17,325 | N/A | 13F |
| HRT FINANCIAL LLC | COM | 15,379 | N/A | 13F |
| Cetera Investment Advisers | COM | 15,000 | N/A | 13F |
| Clear Harbor Asset Management, LLC | COM | 14,500 | N/A | 13F |
| LAZARD ASSET MANAGEMENT LLC | Common Stock | 14,274 | N/A | 13F |
| BANK OF MONTREAL /CAN/ | COM | 13,650 | N/A | 13F |
| Mariner Wealth Advisors, LLC | COM | 12,282 | N/A | 13F |
| CTC Alternative Strategies, Ltd. | COM | 12,100 | N/A | 13F |
| OXFORD ASSET MANAGEMENT | COM | 11,827 | N/A | 13F |
| EVOKE WEALTH, LLC | COM | 10,000 | N/A | 13F |
| PNC FINANCIAL SERVICES GROUP INC | COM | 6,000 | N/A | 13F |
| GROUP ONE TRADING, L.P. | COM | 5,991 | N/A | 13F |
| RHUMBLINE ADVISERS | COM | 4,940 | N/A | 13F |
| SIMPLEX TRADING, LLC | COM | 2,176 | N/A | 13F |
| China Universal Asset Management Co., Ltd. | Common Stock | 1,957 | N/A | 13F |
| Newbridge Financial Services Group, Inc. | COM | 1,500 | N/A | 13F |
| NEW YORK STATE COMMON RETIREMENT FUND | Foreign Stock | 1,165 | N/A | 13F |
| IFP Advisors, Inc | cs | 1,150 | N/A | 13F |
| Advisor Group, Inc. | COM | 425 | N/A | 13F |
| NISA INVESTMENT ADVISORS L L C | COM | 250 | N/A | 13F |
| CITIGROUP INC | COM | 122 | N/A | 13F |
