| Net revenues from research collaborators | 8.71M |
| Research and development | 83.17M |
| General and administrative | 17.99M |
| Total operating expenses | 101.16M |
| Loss from operations | -92.45M |
| Equity in loss of joint venture (Regulus Therapeutics Inc.) | |
| Interest income | |
| Other (expense) income | 229K |
| Total other income (expense) | 2.32M |
| Loss before income taxes | |
| Benefit from income taxes | |
| Net loss | -90.13M |
| Net loss per common share - basic and diluted | -1.05 |
| Weighted average common shares used to compute basic and diluted net loss per common share | |
| Net loss | -90.13M |
| Foreign currency translation | |
| Unrealized (loss) gain on marketable securities | -18.33M |
| Comprehensive loss | -109.41M |
| Research and development | |
| General and administrative | |