H.C. Wainwright Downgrades Prana Biotechnology (PRAN) to Neutral

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Prana Biotechnology (PRAN) Sinks as Alzheimer's Trial Fails

March 31, 2014 8:11 AM EDT

Prana Biotechnology (NASDAQ: PRAN) is trading down 67% in pre-open action after the company's Phase II trail for its PBT2 did not meet its primary endpoint of a statistically significant reduction in the levels of beta-amyloid plaques in the brains of prodromal/mild Alzheimers disease patients.... More

Prana Biotech (PRAN) Reports PBT2 Phase II Did Not Meet Primary Endpoint in Alzheimer's Disease

March 31, 2014 6:15 AM EDT

Prana Biotechnology (Nasdaq: PRAN) has released the top line results of the 12-month Phase II Imaging trial in Alzheimer's Disease (IMAGINE Trial), based on draft results.

Pranas PBT2 did not meet its primary endpoint of a statistically significant reduction in the levels of beta-amyloid plaques in the brains of prodromal/mild Alzheimers disease patients, as measured using PiB-PET Standardized Uptake Value Ratio (SUVR). Whilst there was a reduction in the overall levels of the PiB PET signal in patients treated with PBT2, the results were confounded by an atypical... More