Rigel Pharma (RIGL) Hit as OSKIRA-4 Misses Secondary Endpoint (AZN)
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AstraZeneca (AZN) Updates on OSKIRA-4 Top-Line Results; Did Not Meet Secondary Objective
December 13, 2012 7:37 AM ESTAstraZeneca (NYSE: AZN) announced top-line results of OSKIRA-4, a Phase IIb monotherapy study of fostamatinib, the first kinase inhibitor with selectivity for SYK (spleen tyrosine kinase) in development as an oral treatment for rheumatoid arthritis (RA).
OSKIRA-4 was a six month study evaluating improvements in signs and symptoms of RA in 280 patients who had never previously used a disease-modifying anti-rheumatic drug (DMARD), were DMARD intolerant or had an inadequate response to... More
