Lyell Immunopharma reports safety data for lymphoma CAR T-cell therapy
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Lyell Immunopharma Presents Updated Safety Data and Translational Insights for Rondecabtagene Autoleucel (Ronde-Cel) in Patients with Large B-Cell Lymphoma at European Hematology Association 2026 Cong
June 12, 2026 12:45 PM EDTMore than 100 patients treated with ronde-cel in 2L and 3L+ LBCL, with a manufacturing success rate of 97%No Grade 3 CRS and low rates of Grade 3 ICANS, supporting outpatient administrationTranslational data support biological basis for durable responses, including enhanced memory potential of cytotoxic effector cells from CD62L+ enrichment, and CD19/CD20 dual-targeting to overcome low antigen expressionPiNACLE pivotal clinical trial in 3L+ setting data update expected in second half of 2026; pivotal data readout expected in mid-2027, with BLA submission to follow in the second half of 2027
SOUTH SAN FRANCISCO, Calif., June 12, 2026 (GLOBE... More
