Ionis Pharmaceuticals (IONS) Tops Q3 EPS by 42c, Beats on Revenue; Offers FY25 EPS Guidance

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Ionis reports third quarter 2025 financial results and highlights progress on key programs

October 29, 2025 7:00 AM EDT

- TRYNGOLZA® generated $32 million in net product sales in the third quarter 2025 -

- DAWNZERA (donidalorsen) launch off to encouraging start -

- Olezarsen significantly reduced triglycerides and acute pancreatitis events in severe hypertriglyceridemia (sHTG) in landmark Phase 3 studies; sNDA submission on track by year-end

- Positive pivotal zilganersen results in Alexander disease position Ionis for first independent neurology launch in 2026 -

- Increasing 2025 financial guidance driven by continued strength across the business

CARLSBAD, Calif.--(BUSINESS WIRE)-- Ionis... More