Form S-8 POS Barinthus Biotherapeutic
As filed with the Securities and Exchange Commission on September 9, 2026
Registration No. 333-255664
Registration No. 333-263844
Registration No. 333-270815
Registration No. 333-278111
Registration No. 333-285968
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-255664
Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-263844
Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-270815
Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-278111
Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-285968
UNDER THE SECURITIES ACT OF 1933
BARINTHUS BIOTHERAPEUTICS PLC
(Exact name of Registrant as specified in its charter)
| England and Wales | Not Applicable | |
|
(State or other jurisdiction of incorporation or organization) |
(IRS Employer Identification No.) |
20400 Century Blvd, Suite 210
Germantown, MD 20874
(Address, including zip code, of registrant’s principal executive offices)
Share Award Plan 2021
2021 Employee Share Purchase Plan
EMI Share Option Scheme
(Full title of the plans)
William Enright
Chief Executive Officer
20400 Century Blvd, Suite 210
Germantown, MD 20874
(Name and address of agent for service)
443 917-0966
(Telephone number, including area code, of agent for service)
With a copy to:
Robert E. Puopolo
Marishka DeToy
Janet Hsueh
Goodwin Procter LLP
101 Northern Avenue
Boston, MA 02210
(617) 570-1000
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
| Large accelerated filer | ¨ | Accelerated filer | ¨ |
| Non-accelerated filer | x | Smaller reporting company | x |
| Emerging growth company | x |
If an emerging growth company, indicate by check mark if the registration has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨
EXPLANATORY NOTE
DEREGISTRATION OF SECURITIES
These Post-Effective Amendments (the “Post-Effective Amendments”) relate to the following Registration Statements (collectively, the “Registration Statements”) filed by Barinthus Biotherapeutics plc (the “Company”) with the Securities and Exchange Commission (the “SEC”):
| · | Registration Statement No. 333-255664, filed with the SEC on April 30, 2021, registering (i) 1,895,097 ordinary shares of the Company, nominal value £0.000025 per share (“Ordinary Shares”), represented by 1,895,097 American Depositary Shares of the Company (“ADSs”), issuable pursuant to the Company’s EMI Share Option Scheme (the “EMI Scheme”); (ii) 3,675,680 Ordinary Shares represented by 3,675,680 ADSs pursuant to the Company’s Share Award Plan (the “2021 Plan”); and (iii) 367,568 Ordinary Shares represented by 367,568 ADSs pursuant to the Company’s 2021 Employee Share Purchase Plan (the “2021 ESPP”). |
| · | Registration Statement No. 333-263844, filed with the SEC on March 25, 2022, registering (i) 1,487,549 Ordinary Shares represented by 1,487,549 ADSs issuable pursuant to the 2021 Plan; and (ii) 371,887 Ordinary Shares represented by 371,887 ADSs issuable pursuant to the 2021 ESPP. |
| · | Registration Statement No. 333-270815, filed with the SEC on March 24, 2023, registering (i) 1,507,341 Ordinary Shares represented by 1,507,341 ADSs issuable pursuant to the 2021 Plan; and (ii) 376,835 Ordinary Shares represented by 376,835 ADSs issuable pursuant to the 2021 ESPP. |
| · | Registration Statement No. 333-278111, filed with the SEC on March 20, 2024, registering (i) 1,544,282 Ordinary Shares represented by 1,544,282 ADSs issuable pursuant to the 2021 Plan; and (ii) 386,071 Ordinary Shares represented by 386,071 ADSs issuable pursuant to the 2021 ESPP. |
| · | Registration Statement No. 333-285968, filed with the SEC on March 20, 2025, registering (i) 1,609,386 Ordinary Shares represented by 1,609,386 ADSs issuable pursuant to the 2021 Plan; and (ii) 402,346 Ordinary Shares represented by 402,346 ADSs issuable pursuant to the 2021 ESPP. |
On September 9, 2026, pursuant to the Agreement and Plan of Merger, dated as of September 29, 2025, as amended (the “Merger Agreement”), by and among the Company, Beacon Topco, Inc., a Delaware corporation and a direct wholly-owned subsidiary of Beacon (“Topco”), Cdog Merger Sub, Inc., a Delaware corporation and a direct wholly-owned subsidiary of Topco, and Clywedog Therapeutics, Inc., a Delaware corporation, the scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the “Scheme”) became effective. As a result of the effectiveness of the Scheme, Topco acquired the entire issued and to be issued share capital of the Company, and the Company became a direct wholly-owned subsidiary of Topco.
As a result of the effectiveness of the Scheme, the Company has terminated all of the offerings and sales of the Company’s securities pursuant to the Registration Statements. In accordance with the undertakings made by the Company in each of the Registration Statements to remove from registration, by means of a post-effective amendment, any of the securities of the Company registered under such Registration Statements which remain unsold at the termination of the offering, the Company hereby removes from registration, by means of these Post-Effective Amendments, all of the securities of the Company registered under the Registration Statements that remain unsold as of the date of these Post-Effective Amendments, if any. The Registration Statements are hereby amended, as appropriate, to reflect the deregistration of such securities, and the Company hereby terminates the effectiveness of each of the Registration Statements.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Germantown, State of Maryland, on September 9, 2026.
| Barinthus Biotherapeutics plc | ||
| By: | /s/ William Enright | |
| William Enright | ||
| Chief Executive Officer | ||
No other person is required to sign these Post-Effective Amendments to the Registration Statements in reliance upon Rule 478 under the Securities Act of 1933, as amended.
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