Form S-8 POS Akero Therapeutics, Inc.

Registration No. 333-232234

Registration No. 333-237220

Registration No. 333-254454

Registration No. 333-263194

Registration No. 333-270662

Registration No. 333-277531

Registration No. 333-285416

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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POST-EFFECTIVE AMENDMENT NO. 1

TO

FORM S-8 REGISTRATION STATEMENT NO. 333-232234

FORM S-8 REGISTRATION STATEMENT NO. 333-237220

FORM S-8 REGISTRATION STATEMENT NO. 333-254454

FORM S-8 REGISTRATION STATEMENT NO. 333-263194

FORM S-8 REGISTRATION STATEMENT NO. 333-270662

FORM S-8 REGISTRATION STATEMENT NO. 333-277531

FORM S-8 REGISTRATION STATEMENT NO. 333-285416

UNDER

THE SECURITIES ACT OF 1933

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AKERO THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

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Akero Therapeutics, Inc. 2018 Stock Option and Grant Plan

Akero Therapeutics, Inc. 2019 Stock Option and Incentive Plan

Akero Therapeutics, Inc. 2019 Employee Stock Purchase Plan

(Full title of the plans)

Jonathan Young, J.D., Ph.D.

Assistant Treasurer

601 Gateway Boulevard, Suite 350

South San Francisco, CA 94080

(650) 487-6488

(Name, address, and telephone number, including area code, of agent for service)

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Copies to:

Christopher Comeau

Emily Oldshue

Ropes & Gray LLP

Prudential Tower, 800 Boylston Street

Boston, Massachusetts 02199

(617) 951-7000

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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DEREGISTRATION OF SECURITIES

These Post-Effective Amendments (the “Post-Effective Amendments”) relate to the following Registration Statements on Form S-8 (the “Registration Statements”) filed by Akero Therapeutics, Inc. (“Akero” or the “Company”) with the Securities and Exchange Commission (the “SEC”):

On December 9, 2025 (the “Effective Date”), NN Invest Sub, Inc, a Delaware corporation (“Merger Sub”) and a direct or indirect wholly owned subsidiary of Novo Nordisk A/S, a Danish aktieselskab (“Novo”), completed its merger (the “Merger”) with and into Akero pursuant to the terms of the Agreement and Plan of Merger, dated October 9, 2025 (the “Merger Agreement”), by and among Novo, Merger Sub, and Akero. Akero was the surviving corporation in the Merger and, as a result, is now a wholly owned subsidiary of Novo.

As a result of the Merger, Akero has terminated all offerings and sales of securities pursuant to the Registration Statements. In accordance with the undertakings made by Akero in each Registration Statement to remove from registration, by means of a post-effective amendment, any of the securities that had been registered for issuance under the Registration Statements that remain unsold at the termination of such offering, Akero hereby removes from registration all of such securities registered but remaining unsold under the Registration Statements as of the Effective Date. The Registration Statements are hereby amended, as appropriate, to reflect the deregistration of such securities. After giving effect to the Post-Effective Amendments, there will be no remaining securities registered by Akero pursuant to the Registration Statements.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on this 9th day of December, 2025.

No other person is required to sign these Post-Effective Amendments in reliance on Rule 478 of the Securities Act of 1933.