Form EFFECT GUGGENHEIM DEFINED PORTF

August 27, 2026 6:07 AM EDT
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: August 26, 2026 1:50 P.M.
Form: S-6
CIK: 0002119467
Company Name: GUGGENHEIM DEFINED PORTFOLIOS, SERIES 2621
File Number: 333-296883


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