Form 424B5 BioLineRx Ltd.
Filed Pursuant to Rule 424(b)(5)
Registration No. 333-276323
PROSPECTUS SUPPLEMENT
(To Prospectus Dated January 5, 2024)
Up to $4,800,000 of
American Depositary Shares Representing Ordinary Shares
American Depositary Shares Representing Ordinary Shares
This prospectus supplement amends and supplements certain information in the prospectus, dated January 5, 2024, or the ATM Prospectus, filed with the Securities and Exchange
Commission as part of our registration statement on Form F-3 (333-276323) relating to the offer and sale of American Depositary Shares, or ADSs, representing our ordinary shares, par value NIS 0.10 per share, from time to time pursuant to the terms
of the at-the-market offering agreement, or the Offering Agreement, dated September 3, 2021, with H.C. Wainwright & Co., LLC, or the Sales Agent. This prospectus supplement should be read in conjunction with the ATM Prospectus, and is qualified
by reference thereto, except to the extent that the information herein amends or supersedes the information contained in the ATM Prospectus. This prospectus supplement is not complete without, and may only be delivered or utilized in connection with,
the ATM Prospectus, and any future amendments or supplements thereto.
On March 31, 2025, upon filing our Annual Report on Form 20-F for the fiscal year ended December 31, 2024, we became subject to the offering limits in General Instruction I.B.5 of
Form F-3. As of the date of this prospectus supplement, the aggregate market value of our outstanding voting and non-voting common equity held by non-affiliates pursuant to General Instruction I.B.5 of Form F-3 is $14,562,368, which was calculated
based on a price of $4.11 per share, the closing price of our ADSs on February 18, 2025, which is the highest closing sale price of our ADSs on the Nasdaq Capital Market within the prior 60 days. During the prior 12 calendar month period that ends
on, and includes, the date of this prospectus supplement, we have not sold any sold securities pursuant to General Instruction I.B.5 of Form F-3. Pursuant to General Instruction I.B.5 of Form F-3, in no event will we sell securities in public primary
offerings on Form F-3 with a value exceeding one-third of our public float (as defined by General Instruction I.B.5) in any 12 calendar month period so long as our public float remains below $75.0 million.
Our ADSs are listed on Nasdaq under the symbol
“BLRX”. On April 10, 2025, the closing price of our ADSs on Nasdaq was $2.43 per ADS. Our ordinary shares also trade on the Tel Aviv Stock Exchange, or the TASE, under the symbol “BLRX”. On April 10, 2025, the last reported sale price of our
ordinary shares on the TASE was NIS 0.017 or $0.005 per share (based on the exchange rate reported by the Bank of Israel on the same day).
Investing in our securities involves a high degree of risk. You should read this prospectus supplement and the accompanying prospectus as well as the information
incorporated herein and therein by reference carefully before you make your investment decision. See “Risk Factors” beginning on page S-5 of the ATM Prospectus and on page S-1 of the accompanying prospectus, and the risk factors described in other
documents incorporated by reference therein, to read about the factors you should consider before investing in our securities.
Neither the Securities and Exchange Commission, the Israel Securities Authority nor any state or other foreign securities commission has approved or
disapproved of these securities or determined if this prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal offense.
H.C. Wainwright & Co.
The date of this prospectus supplement is April 11, 2025.
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