Form 10-Q SYNERGY PHARMACEUTICALS, For: Mar 31

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May 10, 2016 4:19 PM EDT


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-Q

(Mark One)

x      QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE QUARTERLY PERIOD ENDED: March 31, 2016

o         TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                      to

Commission File Number: 001-35268

SYNERGY PHARMACEUTICALS INC.
(Exact name of registrant as specified in its charter)
Delaware
 
33-0505269
(State or Other Jurisdiction of Incorporation or Organization)
 
(I.R.S. Employer Identification No.)

420 Lexington Avenue, Suite 2012, New York, New York 10170
(Address of principal executive offices) (Zip Code)

(212) 297-0020
(Registrant’s telephone number)

(Former Name, Former Address and Former Fiscal Year, if changed since last report)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.  Yes x  No o

Indicate by check mark whether the Registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit and post such files).  Yes x  No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of “large accelerated filer,” “accelerated filer,” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer o
 
Accelerated filer x
 
 
 
Non-accelerated filer o
 
Smaller reporting company o
(Do not check if a smaller reporting company)
 
 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).  Yes o No x

The number of the registrant’s shares of common stock outstanding was 179,776,089 as of May 10, 2016.
 



SYNERGY PHARMACEUTICALS INC.

FORM 10-Q

TABLE OF CONTENTS

 
 
Page
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


2

NOTE REGARDING FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q for Synergy Pharmaceuticals Inc. may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward-looking statements are characterized by future or conditional verbs such as “may,” “will,” “expect,” “plan” “intend,” “anticipate,” believe,” “estimate” and “continue” or similar words. You should read statements that contain these words carefully because they discuss future expectations and plans, which contain projections of future results of operations or financial condition or state other forward-looking information. Such statements are only predictions and our actual results may differ materially from those anticipated in these forward-looking statements. We do not assume any obligation to update forward-looking statements as circumstances change and thus you should not unduly rely on these statements, which speak only as of the date of this Quarterly Report on Form 10-Q.

We believe that it is important to communicate future expectations to readers. However, there may be events in the future that we are not able to accurately predict or control. Risk factors that may cause such differences between predicted and actual results include, but are not limited to, those discussed in our Form 10-K for the year ended December 31, 2015 and other periodic reports filed with the Securities and Exchange Commission.

These risk factors include the uncertainties associated with product development, the risk that products that appeared promising in early clinical trials do not demonstrate safety and efficacy in larger-scale clinical trials, the risk that we will not obtain approval to market our products, the risks associated with dependence upon key personnel and the need for additional financing.


3

PART I—FINANCIAL INFORMATION

Item 1.    Financial Statements

SYNERGY PHARMACEUTICALS INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In thousands, except share amounts)
 
March 31, 2016
(unaudited)
 
December 31, 2015
 
 
 
 
ASSETS
 
 
 
Current Assets:
 
 
 
Cash and cash equivalents
$
84,155

 
$
61,653

Available-for-sale securities
—

 
50,097

Prepaid expenses and other current assets
3,361

 
3,305

Total Current Assets
87,516

 
115,055

Property and equipment, net
534

 
531

Security deposits
343

 
343

Total Assets
$
88,393

 
$
115,929

LIABILITIES AND STOCKHOLDERS’ DEFICIT
 
 
 
Current Liabilities:
 
 
 
Accounts payable
$
13,561

 
$
13,263

Accrued expenses
3,229

 
4,328

Interest payable on Senior Convertible Debentures
2,474

 
1,988

Total Current Liabilities
19,264

 
19,579

Senior Convertible Notes, net of deferred financing costs of $3,617 and $7,769 as of March 31, 2016 and December 31, 2015, respectively
75,565

 
151,241

Derivative financial instruments, at estimated fair value-warrants
62

 
322

Total Liabilities
94,891

 
171,142

Commitments and contingencies


 


Stockholders’ Deficit:
 
 
 
Preferred stock, Authorized 20,000,000 shares and none outstanding, at March 31, 2016 and December 31, 2015
—

 
—

Common stock, par value of $.0001, 350,000,000 shares authorized at March 31, 2016 and December 31, 2015. Issued and outstanding 149,821,088 shares and 113,694,606 shares at March 31, 2016 and December 31, 2015, respectively.
15

 
11

Additional paid-in capital
437,813

 
329,161

Accumulated deficit
(444,326
)
 
(384,385
)
Total Stockholders’ Deficit
(6,498
)
 
(55,213
)
Total Liabilities and Stockholders’ Deficit
$
88,393

 
$
115,929


The accompanying notes are an integral part of these condensed consolidated financial statements.


4

SYNERGY PHARMACEUTICALS INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(Unaudited)
(In thousands, except share and per share amounts)
 
Three Months Ended March 31,
 
2016
 
2015
Revenues
$
—

 
$
—

 
 
 
 
Costs and Expenses:
 
 
 
Research and development
21,175

 
18,198

Selling, general and administrative
6,375

 
4,606

Loss from Operations
(27,550
)
 
(22,804
)
Other Loss
 
 
 
Interest and investment expense, net
(7,036
)
 
(4,317
)
Debt conversion expense
(25,615
)
 
—

Change in fair value of derivative instruments-warrants
260

 
(268
)
Total Other Loss
(32,391
)
 
(4,585
)
Net Loss
$
(59,941
)
 
$
(27,389
)
 
 
 
 
Weighted Average Common Shares Outstanding
 
 
 
Basic and Diluted
117,626,669

 
96,683,525

 
 
 
 
Net Loss per Common Share, Basic and Diluted
 
 
 
Net Loss per Common Share, Basic and Diluted
$
(0.51
)
 
$
(0.28
)

The accompanying notes are an integral part of these condensed consolidated financial statements.


5

SYNERGY PHARMACEUTICALS INC.
CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS’ DEFICIT
(Unaudited)
(In thousands, except share amounts)
 
Common
Shares
 
Common
Stock,
Par Value
 
Additional
Paid in
Capital
 
Deficit
Accumulated
 
Total
Stockholders’
Deficit
 
 
 
 
 
 
 
 
 
 
Balance, January 1, 2016
113,694,606

 
$
11

 
$
329,161

 
$
(384,385
)
 
$
(55,213
)
Notes conversions including shares issued for accrued interest
26,532,731

 
3

 
82,271

 
—

 
82,274

Debt conversion expense
9,593,751

 
1

 
25,614

 
—

 
25,615

Transaction fees on Note conversions
—

 
—

 
(435
)
 
—

 
(435
)
Stock based compensation expense
—

 
 
 
1,202

 
—

 
1,202

Net loss for the period
—

 
—

 
—

 
(59,941
)
 
(59,941
)
Balance, March 31, 2016
149,821,088

 
$
15

 
$
437,813

 
$
(444,326
)
 
$
(6,498
)

The accompanying notes are an integral part of these condensed consolidated financial statements.


6

SYNERGY PHARMACEUTICALS INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited)
(In thousands)
 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Cash Flows From Operating Activities:
 
 
 
Net loss
$
(59,941
)
 
$
(27,389
)
Adjustments to reconcile net loss to net cash used in operating activities:
 
 
 
Depreciation and amortization
38

 
34

Amortization of deferred financing costs
4,153

 
617

Stock-based compensation expense
1,202

 
2,405

Accretion of discount/premium on available for sale securities


 
(13
)
Change in fair value of derivative instruments—warrants
(260
)
 
268

Common stock issued for interest on Notes
2,445

 
—

Debt conversion expense
25,615

 
—

Transaction fees on Note conversions
(435
)
 
—

Changes in operating assets and liabilities:
 
 
 
Security deposit
—

 
(56
)
Accounts payable and accrued expenses
(800
)
 
(2,952
)
Prepaid expenses and other current assets
(56
)
 
187

Accrued interest expense on Senior Convertible Debentures
487

 
3,750

Total Adjustments
32,389

 
4,240

Net Cash used in Operating Activities
(27,552
)
 
(23,149
)
Cash Flows From Investing Activities:
 
 
 
Net sales (purchases) of available-for-sale securities
50,097

 
(50,000
)
Additions to property and equipment
(43
)
 
(8
)
Net Cash provided by (used in) Investing Activities
50,054

 
(50,008
)
Cash Flows From Financing Activities:
 
 
 
Proceeds of sale of common stock
—

 
5,558

Fees and expenses — sale of common stock
—

 
(153
)
Net Cash provided by Financing Activities
—

 
5,405

Net increase (decrease) in cash and cash equivalents
22,502

 
(67,752
)
Cash and cash equivalents at beginning of period
61,653

 
146,470

Cash and cash equivalents at end of period
$
84,155

 
$
78,718

Supplementary disclosure of cash flow information:
 
 
 
Cash paid for taxes
$
45

 
$
122

Supplementary disclosure of non-cash investing and financing activities:
 
 
 
Conversion of Senior Convertible Debentures to Synergy Common Stock
$
82,274

 
$
—


The accompanying notes are an integral part of these condensed consolidated financial statements.


7

SYNERGY PHARMACEUTICALS INC.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(Unaudited)

1. Business Overview

Synergy Pharmaceuticals Inc. (the “Company” or ‘Synergy”) is a biopharmaceutical company focused on the development and commercialization of novel gastrointestinal (GI) therapies. Since the Company’s inception in 2008, it has pioneered discovery, research and development efforts in the treatment of functional GI disorders and inflammatory bowel disease (IBD). Synergy's proprietary GI platform is based on uroguanylin, a naturally occurring human GI peptide, and includes two lead product candidates - plecanatide and dolcanatide.

Net cash used in operating activities was approximately $27.6 million for the three months ended March 31, 2016. As of March 31, 2016, Synergy had approximately $84.2 million of cash and cash equivalents. During the three months ended March 31, 2016, Synergy incurred losses from operations of $27.6 million. As of March 31, 2016, Synergy had working capital of approximately $68.3 million.

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.

2. Basis of Presentation

These unaudited condensed consolidated financial statements include Synergy and its wholly-owned subsidiaries:  (1) Synergy Advanced Pharmaceuticals, Inc., (2) IgX, Ltd (Ireland—inactive). These unaudited condensed consolidated financial statements have been prepared following the requirements of the Securities and Exchange Commission (“SEC”) and United States generally accepted accounting principles (“GAAP”) for interim reporting. In the opinion of management, the accompanying unaudited condensed consolidated financial statements include all adjustments, which include only normal recurring adjustments, necessary to present fairly Synergy’s interim financial information. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2015 contained in the Company’s Annual Report on Form 10-K filed with the SEC on February 25, 2016. All intercompany balances and transactions have been eliminated.

Synergy will be required to raise additional capital within the next year to continue the development and commercialization of current product candidates and to continue to fund operations at the current cash expenditure levels. Synergy cannot be certain that additional funding will be available on acceptable terms, or at all. To the extent that Synergy raises additional funds by issuing equity securities, Synergy’s stockholders may experience significant dilution. Any debt financing, if available, may involve restrictive covenants that impact Synergy’s ability to conduct business. If Synergy is unable to raise additional capital when required or on acceptable terms, Synergy may have to (i) significantly delay, scale back or discontinue the development and/or commercialization of one or more product candidates; (ii) seek collaborators for product candidates at an earlier stage than otherwise would be desirable and on terms that are less favorable than might otherwise be available; or (iii) relinquish or otherwise dispose of rights to technologies, product candidates or products that Synergy would otherwise seek to develop or commercialize ourselves on unfavorable terms.
Synergy's consolidated financial statements as of December 31, 2015 and its condensed consolidated financial statements as of March 31, 2016 have been prepared under the assumption that it will continue as a going concern for the next twelve months. Its independent registered public accounting firm has issued a report as of December 31, 2015 that includes an explanatory paragraph referring to the Company's recurring and continuing losses from operations and expressing substantial doubt in the Company's ability to continue as a going concern without additional capital becoming available. Synergy's ability to continue as a going concern is dependent upon its ability to obtain additional equity or debt financing, attain further operating efficiencies, reduce expenditures, and, ultimately, to generate revenue. Synergy's consolidated financial statements as of December 31, 2015 and its condensed consolidated financial statements as of March 31, 2016 do not include any adjustments that might result from the outcome of this uncertainty.

8

3. Recent Accounting Pronouncements

In March 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2016-09, “Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting” (“ASU 2016-09”). The standard is intended to simplify several areas of accounting for share-based compensation arrangements, including the income tax impact, classification on the statement of cash flows and forfeitures. ASU 2016-09 is effective for fiscal years, and interim periods within those years, beginning after December 15, 2016, and early adoption is permitted. The Company is currently evaluating the impact that the standard will have on its condensed consolidated financial statements.

In February 2016, the FASB issued ASU 2016-02 “Leases (Topic 842)” (“ASU 2016-02”). The FASB issued ASU 2016-02 to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities on the balance sheet and disclosing key information about leasing arrangements. Under ASU 2016-02, a lessee will recognize in the statement of financial position a liability to make lease payments (the lease liability) and a right-to-use asset representing its right to use the underlying asset for the lease term. The recognition, measurement, and presentation of expenses and cash flows arising from a lease by a lessee have not significantly changed from current GAAP. ASU 2016-02 retains a distinction between finance leases (i.e. capital leases under current GAAP) and operating leases. The classification criteria for distinguishing between finance leases and operating leases will be substantially similar to the classification criteria for distinguishing between capital leases and operating leases under current GAAP. The amendments of this ASU are effective for reporting periods beginning after December 15, 2018, with early adoption permitted. An entity will be required to recognize and measure leases at the beginning of the earliest period presented using a modified retrospective approach. Management is currently assessing the impact the adoption of ASU 2016-02 will have on its Financial Statements.

In January 2016, the FASB issued ASU 2016-01, "Financial Instruments—Overall (Topic 825-10): "Recognition and Measurement of Financial Assets and Financial Liabilities." ASU 2016-01 amends the guidance on the classification and measurement of financial instruments. Some of the amendments in ASU 2016-01 include the following: 1) requires equity investments (except those accounted for under the equity method of accounting or those that result in consolidation of the investee) to be measured at fair value with changes in fair value recognized in net income; 2) simplifies the impairment assessment of equity investments without readily determinable fair values by requiring a qualitative assessment to identify impairment; 3) requires public business entities to use the exit price notion when measuring the fair value of financial instruments for disclosure purposes; and 4) requires an entity to present separately in other comprehensive income the portion of the total change in the fair value of a liability resulting from a change in the instrument-specific credit risk when the entity has elected to measure the liability at fair value; among others. For public business entities, the amendments of ASU 2016-01 are effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures, if any.

In April 2015, the FASB issued ASU No. 2015-03 Simplifying the Presentation of Debt Issuance Costs, which changes the presentation of debt issuance costs in the financial statements. Under the standard, debt issuance costs are presented in the balance sheet as a direct deduction from the related debt liability rather than as an asset. In addition amortization of debt issuance costs are to be combined with interest expense in the statement of operations. The guidance is effective for annual and interim reporting periods beginning after December 15, 2015. The Company adopted this guidance during the quarter ended June 30, 2015. (See Note 5)

In August 2014, the FASB issued Accounting Standards Update (“ASU”) No. 2014-15, “Presentation of Financial Statements - Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern.” This ASU provides guidance on management’s responsibility to evaluate whether there is substantial doubt about an entity’s ability to continue as a going concern or to provide related footnote disclosures. The amendments require management to assess an entity’s ability to continue as a going concern by incorporating and expanding upon certain principles that are currently in U.S. auditing standards. The new standard will be effective for annual periods ending after December 15, 2016, and interim periods within annual periods beginning after December 15, 2016. Early adoption is permitted. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures.

4. Cash, Cash Equivalents and Available-for-sale Securities

All highly liquid investments with maturities of three months or less at the date of purchase are classified as cash equivalents. As of March 31, 2016 and December 31, 2015, the amount of cash and cash equivalents was $84.2 million and $61.7 million, respectively and consists of checking accounts and short-term money market mutual funds. Checking accounts are held at U.S. commercial banks, and balances were in excess of the FDIC insurance limit.


9

The Company had no available-for-sale securities as of March 31, 2016 and $50.1 million of available-for-sale securities as of December 31, 2015. Management determines the appropriate classification of its investments at the time of purchase and reevaluates the available-for-sale designations as of each balance sheet date.

5. Senior Convertible Notes

On November 3, 2014, Synergy closed a private offering of $200 million aggregate principal amount of 7.50% Convertible Senior Notes due 2019 (including the full exercise of the over-allotment option granted to the initial purchasers to purchase an additional $25 million aggregate principal amount of 7.50% Convertible Senior Notes due 2019, (the “Notes”), interest payable semiannually in arrears on May 1 and November 1 of each year, beginning on May 1, 2015. The net proceeds from the offering were $187.3 million after deducting the initial purchasers’ discounts and offering expenses.

The Notes are unsecured. Interest expense not including amortization of deferred financing costs for three months ended March 31, 2016 and 2015 was $0.5 million and $3.8 million, respectively. Accrued interest payable was $2.5 million and $2.0 million as of March 31, 2016 and December 31, 2015 respectively.

A summary of quarterly activity is listed below (dollars in thousands):

Interest payable on Senior Convertible Debenture at 1/1/2015
$
2,500

Accrued interest expense during the 3 months ended March 31, 2015
3,750

Interest Payable on Senior Convertible Debenture at March 31, 2015
6,250

Accrued interest expense during the 3 months ended June 30, 2015
3,388

Interest Payment on Senior Convertible Debenture at May 1, 2015
(7,416
)
Interest payable on Senior Convertible Debenture as of June 30, 2015
2,222

Accrued interest expense during the 3 months ended September 30, 2015
2,747

Interest payable on Senior Convertible Debenture as of September 30, 2015
4,969

Interest payment at November 1, 2015
(5,963
)
Accrued interest expense during the 3 months ended December 31, 2015
2,982

Interest payable as of December 31, 2015
1,988

Accrued interest expense during the 3 months ended March 31, 2016
486

Interest payable as of March 31, 2016
$
2,474


The Notes will mature on November 1, 2019, unless earlier purchased or converted. The Notes are convertible, at any time, into shares of Synergy’s common stock at an initial conversion rate of 321.5434 shares per $1,000 principal amount of notes, which is equivalent to the original conversion price of $3.11 per share. Subsequent to the exchange described above, the principal balance of the Notes at March 31, 2016 is $79.2 million as compared to $159.0 million at December 31, 2015. Transaction costs associated with the sale of the Notes of $12.7 million have been deferred and are being recognized as expense over the expected term of the Notes, calculated using the effective interest rate method. Amortization expense, including amortization associated with reduction of the principal due to the conversion and exchanges of the debentures on a prorated basis for three months ended March 31, 2016 and 2015 was $4.2 million and 0.6 million, respectively. The remaining transaction costs have been presented as a reduction of the Notes in accordance with the newly adopted Accounting Standards Update (“ASU”) No. 2015-3 “Simplifying the Presentation of Debt Issuance Costs”.

On March 18, 2016 Synergy entered into an exchange agreement for the exchange of $79.8 million in aggregate principal amount of the Notes, representing approximately 50% of the outstanding aggregate principal amount of Notes, for 35.3 million shares of Synergy's common stock, with a total of 25.7 million shares representing the conversion price of $3.11 pursuant to the existing terms of the Notes. Synergy also issued approximately 872,000 shares at the five day average share price of $2.81 in payment of accrued and unpaid interest of $2.4 million on Notes accepted in the Exchanges, from the applicable last interest payment date to, but not including, March 28, 2016. The amortization of deferred financing costs was accelerated consistent with the 50% reduction of aggregate principal amount this transaction represented, and resulted in additional interest expense of approximately $3.6 million. GAAP requires that such conversions be treated as induced conversions with an expense recognized equal to the fair value of the securities and other consideration transferred in the transaction in excess of the fair value of the securities issuable pursuant to the original conversion terms, with such fair value being measured as of the date the inducement offer is accepted by the convertible debt holder. Accordingly, the Company recognized a debt conversion expense of $25.6 million for the three months ended March 31, 2016.

10


A summary of quarterly activity and balances associated with the Notes and related deferred transaction costs is presented below ($ in thousands):

 
Notes Balance
 
Transactions
Costs
 
Notes, net of
Transaction
Costs
Balance at issuance November 1, 2014
$
200,000

 
$
12,747

 
$
187,253

Less: amortization two months ended December 31, 2014
—

 
(411
)
 
411

Balance December 31, 2014
200,000

 
12,336

 
187,664

Less: amortization three months ended March 31, 2015
—

 
(617
)
 
617

Balance March 31, 2015
200,000

 
11,719

 
188,281

Less: amortization three months ended June 30, 2015 (1)
—

 
(1,899
)
 
1,899

Conversions
(22,213
)
 
—

 
(22,213
)
Balance June 30, 2015
177,787

 
9,820

 
167,967

Less: amortization three months ended September 30, 2015 (1)
—

 
(1,544
)
 
1,544

Conversions
(18,776
)
 
—

 
(18,776
)
Balance, September 30, 2015
159,011

 
8,276

 
150,735

Less: amortization three months ended December 31, 2015 
—

 
(506
)
 
506

Balance December 31, 2015
159,011

 
7,770

 
151,241

Less: amortization three months ended March 31, 2016 (1)
—

 
(4,153
)
 
4,153

Conversions
(79,829
)
 
—

 
(79,829
)
Balance, March 31, 2016
$
79,182

 
$
3,617

 
$
75,565

_____________________
(1) Includes accelerated amortization of deferred financing costs attributable to conversions and exchanges

6. Accounting for Shared-Based Payments

Stock Options

ASC Topic 718 “Compensation—Stock Compensation” requires companies to measure the cost of employee services received in exchange for the award of equity instruments based on the estimated fair value of the award at the date of grant. The expense is to be recognized over the period during which an employee is required to provide services in exchange for the award.  Synergy accounts for shares of common stock, stock options and warrants issued to employees based on the fair value of the stock, stock option or warrant, if that value is more reliably measurable than the fair value of the consideration or services received.

The Company accounts for stock options issued and vesting to non-employees in accordance with ASC Topic 505-50 “ Equity -Based Payment to Non-Employees” and accordingly the value of the stock compensation to non-employees is based upon the measurement date as determined at either a) the date at which a performance commitment is reached, or b) at the date at which the necessary performance to earn the equity instruments is complete. Accordingly the fair value of these options is being “marked to market” quarterly until the measurement date is determined.

Synergy adopted the 2008 Equity Compensation Incentive Plan (the “Plan”) during the quarter ended September 30, 2008. Stock options granted under the Plan typically vest after three years of continuous service from the grant date and have a contractual term of ten years. On June 8, 2015, Synergy amended its 2008 Equity Compensation Incentive Plan and increased the number of shares of its common stock reserved for issuance under the Plan from 15,000,000 to 30,000,000.

Stock-based compensation has been recognized in operating results as follows:


11

 
 
Three Months Ended
March 31,
($ in thousands)
 
2016
 
2015
Employees—included in research and development
 
810

 
530

Employees—included in general and administrative
 
392

 
1,875

Total stock-based compensation expense
 
$
1,202

 
$
2,405


The unrecognized compensation cost related to non-vested stock options outstanding at March 31, 2016, net of expected forfeitures, was approximately $16.3 million to be recognized over a weighted-average remaining vesting period of approximately 1.94 years. This unrecognized compensation cost does not include amounts related to 4,319,000 shares of stock options which vest and will be measured upon a change of control.

The estimated fair value of stock option awards was determined on the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions during the periods indicated.

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Risk-free interest rate
1.47%-1.74%

 
1.46%-2.02%

Dividend yield
—

 
—

Expected volatility
60
%
 
57
%
Expected term (in years)
6 years

 
6-9.3 years


A summary of stock option activity and of changes in stock options outstanding under the Plan is presented below:

 
Number of
Options
 
Exercise Price
Per Share
 
Weighted Average
Exercise Price
Per Share
 
Intrinsic
Value
(in thousands)
 
Weighted Average
Remaining
Contractual Term
Balance outstanding, December 31, 2015 (1)
20,953,375

 
$0.44-9.12
 
$
3.86

 
$
42,438

 
7.15 years
Granted
405,000

 
$3.12-4.14
 
4.00

 
—

 

Exercised
—

 
0
 
—

 
—

 

Forfeited
(130,427
)
 
$6-9.12
 
6.65

 
—

 

Balance outstanding, March 31, 2016 (1)
21,227,948

 
0.44-9.12
 
$
3.83

 
$
—

 
7.00 years
Exercisable, at March 31, 2016
9,991,733

 
0.44-9.12
 
$
3.30

 
$
4,347

 
5.82 years
__________________________
(1)   Number of options represented above includes 2,159,500 options vesting upon a change of control, granted between November 20, 2009 and June 22, 2010. The fair value at the date of grant was approximately $28.6 million. Because the probability of a change of control transaction is not predictable no stock based compensation expense associated with these options has been recognized since the grant date.

7. Stockholders’ Deficit

On March 18, 2016 Synergy entered into an exchange agreement (the "Exchange") for the exchange of $79.8 million in aggregate principal amount of the Notes, representing approximately 50% of the outstanding aggregate principal amount of Notes, for 35.3 million shares of its common stock (the “Shares”), with a total of 25.7 million shares representing the conversion price of $3.11 pursuant to the existing terms of the Notes. Synergy also issued approximately 872,000 shares at the five day average share price of $2.81 in payment of accrued and unpaid interest of $2.4 million on Notes accepted in the Exchanges.

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The

12

net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.


8. Research and Development Expense

Research and development costs include expenditures in connection with an in-house research and development laboratory, salaries and staff costs, application and filing for regulatory approval of proposed products, purchased in-process research and development, regulatory and scientific consulting fees, as well as contract research, patient costs, drug formulation and tableting, data collection, monitoring, and clinical insurance.

In accordance with FASB ASC Topic 730-10-55, Research and Development, Synergy recorded prepaid research and development costs of approximately $2.8 million as of March 31, 2016 and $3.1 million as of December 31, 2015, for nonrefundable pre-payments for production of drug substance and analytical testing services for its drug candidates. In accordance with this guidance, Synergy expenses these costs when drug compound is delivered and services are performed.

9. Derivative Financial Instruments

Synergy Derivative Financial Instruments

Effective January 1, 2009, the Company adopted provisions of ASC Topic 815-40, “Derivatives and Hedging: Contracts in Entity’s Own Equity” (“ASC Topic 815-40”). ASC Topic 815-40 clarifies the determination of whether an instrument issued by an entity (or an embedded feature in the instrument) is indexed to an entity’s own stock, which would qualify as a scope exception under ASC Topic 815-10.

Based upon the Company’s analysis of the criteria contained in ASC Topic 815-40, Synergy has determined that certain warrants issued in connection with sale of its common stock must be classified as derivative instruments. In accordance with ASC Topic 815-40, these warrants are also being re-measured at each balance sheet date based on estimated fair value, and any resultant changes in fair value are being recorded in the Company’s statement of operations. The Company estimates the fair value of certain warrants using the Black-Scholes option pricing model in order to determine the associated derivative instrument liability and change in fair value described above. The range of assumptions used to determine the fair value of the warrants at each period end was:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Fair value of Synergy common stock
$
2.76

 
$
4.62

Expected warrant term
1.9

 
0.25-2.9 years

Risk-free interest rate
0.80
%
 
0.03%-0.89%

Expected volatility
60
%
 
57
%
Dividend yield
—

 
—


Fair value of stock is the closing market price of the Company’s common stock at the end of each reporting period when the derivative instruments are marked to market. Expected volatility is a management estimate of future volatility, over the expected warrant term, based on historical volatility of Synergy’s common stock. The warrants have a transferability provision and based on guidance provided in SAB 107 for instruments issued with such a provision, Synergy used the full contractual term as the expected term of the warrants. The risk free rate is based on the U.S. Treasury security rates for maturities consistent with the expected remaining term of the warrants at the date quarterly revaluation.


13

The following table sets forth the components of changes in the Synergy’s outstanding warrants which were deemed derivative financial instruments and the associated liability balance for the periods indicated:

Date
 
Description
 
Warrants
 
Derivative
Instrument
Liability
(in thousands)
12/31/2015
 
Balance of derivative financial instruments liability
 
210,000

 
$
322

3/31/2016
 
Change in fair value of warrants during the quarter
 
—

 
(260
)
3/31/2016
 
Balance of derivative financial instruments liability
 
210,000

 
$
62


10. Fair Value Measurements

Financial instruments consist of cash and cash equivalents, marketable securities, accounts payable and derivative instruments. These financial instruments are stated at their respective historical carrying amounts, which approximate fair value due to their short term nature, except for marketable securities and derivative instruments which are marked to market at the end of each reporting period.

The value of Senior Convertible Notes is stated at its carrying value at March 31, 2016. The Company believes it could obtain borrowings at March 31, 2016 at comparable interest rates as the November 2014 Notes, therefore, the carrying value approximates fair value.

The following table presents the Company’s liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of December 31, 2015 and March 31, 2016

($ in thousands)

Description
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
December 31, 2015
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
—

 
$
—

 
$
322

 
$
322

 
$
—

 
$
—

 
$
62

 
$
62


The following table sets forth a summary of changes in the fair value of the Company’s Level 3 liabilities for the nine months ended March 31, 2016:

($ in thousands)

Description
 
Balance as of
December 31, 2015
 
(Gain) or loss
recognized in
earning from
Change in Fair
Value
 
Expiration of
warrants
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
322

 
$
(260
)
 
$
—

 
$
62


The unrealized gains or losses on the derivative liabilities are recorded as a change in fair value of derivative liabilities in the Company’s statement of operations. A financial instrument’s level within the fair value hierarchy is based on the lowest level of any input that is significant to the fair value measurement. At each reporting period, Synergy reviews the assets and liabilities that are subject to ASC Topic 815-40. At each reporting period, all assets and liabilities for which the fair value measurement is based on significant unobservable inputs or instruments which trade infrequently and therefore have little or no price transparency are classified as Level 3.

11. Loss per Share

Basic and diluted net loss per share is presented in conformity with ASC Topic 260, Earnings per Share, (“ASC Topic 260”) for periods presented. In accordance with ASC Topic 260, basic and diluted net loss per common share was determined

14

by dividing net loss applicable to common stockholders by the weighted-average common shares outstanding during the period. Diluted weighted-average shares are the same as basic weighted-average shares because shares issuable pursuant to the exercise of stock options and warrants would be antidilutive.

The following table sets forth potential common shares issuable upon the exercise of outstanding options, the exercise of warrants, and the conversion of the Senior Convertible Notes, all of which have been excluded from the computation of diluted weighted average shares outstanding as they would be anti-dilutive, including the impact on dilutive net loss per share of in-the-money warrants as per ASC 260-10-45-35 through ASC 260-10-45-37:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Stock Options
21,227,948

 
16,621,065

Warrants
4,726,823

 
5,951,071

Senior Convertible Notes
25,460,450

 
64,308,682

Total shares issuable upon exercise or conversion
51,415,221

 
86,880,818



15

12. Subsequent Events

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share.
The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016


16

ITEM 2.  MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

    
The following discussion should be read in conjunction with our condensed consolidated financial statements and other financial information appearing elsewhere in this quarterly report. In addition to historical information, the following discussion and other parts of this quarterly report contain forward-looking statements. You can identify these statements by forward-looking words such as “plan,” “may,” “will,” “expect,” “intend,” “anticipate,” believe,” “estimate” and “continue” or similar words. Forward-looking statements include information concerning possible or assumed future business success or financial results. You should read statements that contain these words carefully because they discuss future expectations and plans, which contain projections of future results of operations or financial condition or state other forward-looking information. We believe that it is important to communicate future expectations to investors. However, there may be events in the future that we are not able to accurately predict or control. Accordingly, we do not undertake any obligation to update any forward-looking statements for any reason, even if new information becomes available or other events occur in the future and thus you should not unduly rely on these statements.

The forward-looking statements included herein are based on current expectations that involve a number of risks and uncertainties set forth under “Risk Factors” in our Annual Report on Form 10-K as of and for the year ended December 31, 2015 and other periodic reports filed with the United States Securities and Exchange Commission (“SEC”), on February 25, 2016. Accordingly, to the extent that this Report contains forward-looking statements regarding the financial condition, operating results, business prospects or any other aspect of the Company, please be advised that the Company’s actual financial condition, operating results and business performance may differ materially from that projected or estimated by the Company in forward-looking statements and thus you should not unduly rely on these statements.

Business Overview

Since the company’s inception in 2008, we have pioneered discovery, research and development efforts in the treatment of functional GI disorders and inflammatory bowel disease (IBD). Our proprietary GI platform is based on uroguanylin, a naturally occurring human GI peptide, and includes two lead product candidates - plecanatide and dolcanatide.
 
Plecanatide is our first uroguanylin analog currently being evaluated for use as a once-daily tablet for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Plecanatide is a 16-amino acid peptide that is structurally similar to uroguanylin with the exception of a single amino acid change. Plecanatide is designed to replicate the function of uroguanylin by working locally in the upper GI tract to stimulate digestive fluid movement and support regular bowel function. In 2015, we announced positive phase 3 data with plecanatide in two pivotal CIC clinical trials and on January 29, 2016 we filed our first new drug application (NDA) with the U.S. Food and Drug Administration (FDA) for plecanatide in CIC. The FDA Prescription Drug User Fee Act (PDUFA) target action date is January 29, 2017. We presently have two ongoing phase 3 clinical trials with plecanatide in IBS-C and intend to file our second NDA for plecanatide in IBS-C by the end of this year. We expect top-line data from both pivotal IBS-C trials in the third quarter of this year.

    Dolcanatide is our second uroguanylin analog currently being explored for IBD. Dolcanatide is designed to be an analog of uroguanylin with enhanced resistance to standard digestive breakdown by proteases in the intestine. In January 2016, we announced positive data with dolcanatide in a phase 1b trial evaluating 28 patients with mild-to-moderate ulcerative colitis. We are currently evaluating how best to move dolcanatide forward in clinical development to treat ulcerative colitis.

Recent Developments

Plecanatide


•
On January 29, 2016, we filed our first NDA with the FDA for plecanatide in CIC. On April 19, 2016, we announced the plecanatide NDA was accepted for FDA review and the PDUFA target action date is January 29, 2017. The plecanatide NDA is supported by two double-blind placebo-controlled phase 3 trials and one open-label long term safety study. A total of more than 2,700 patients with CIC received a once-daily dose of either plecanatide or placebo across the two placebo-controlled trials. Additionally, over 3,500 patients were exposed to plecanatide in the CIC clinical development program.


17

•
We are continuing to progress our two ongoing phase 3 trials with plecanatide for IBS-C with constipation (IBS-C). We expect top-line data from both pivotal trials in the third quarter of this year and we remain on-track to file our second NDA for plecanatide in IBS-C by the end of this year.

Dolcanatide

•
On January 11, 2016, we announced positive proof-of-concept data with dolcanatide in patients with ulcerative colitis. This was a phase 1b double-blind, placebo-controlled, four-week study evaluating 28 patients with mild-to-moderate ulcerative colitis. Analysis of the data indicates clear signals of improvement in dolcanatide-treated patients compared with placebo-treated patients. Dolcanatide was safe and well tolerated. We are presently evaluating how best to move dolcanatide forward in clinical development for the treatment of ulcerative colitis.
 
BIND Collaboration

•
On February 16, 2016, we announced that we entered into a research collaboration agreement with BIND Therapeutics to develop ACCURINS® decorated with our proprietary uroguanylin analogs to explore the potential targeting of guanylate cyclase-C (GC-C) receptors expressed on tumors, specifically GI malignancies. On May 2, 2016 BIND Therapeutics announced that it had elected to file a voluntary petition under Chapter 11 of the Bankruptcy Code in the U.S. Bankruptcy Court for the District of Delaware.  BIND stated they intend to continue their development and collaboration activities and do not anticipate any disruption to our current collaboration.  As previously stated, this early research collaboration is not expected to have a material financial impact on us or BIND Therapeutics.”
•


Financial

•
On May 5, 2016 We announced that we had entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.


•
On March 28, 2016, we announced the closing of separate, privately-negotiated exchanges with eligible holders of approximately 50% of our outstanding 7.50% Convertible Senior Notes (“Notes”) due 2019. At the closing, and in satisfaction of the consideration for $79.8 million in aggregate principal amount of the Notes, Synergy issued 35.3 million shares of its common stock (the “Shares”). Synergy also issued approximately 872,000 Shares in payment of accrued and unpaid interest on Notes accepted in the Exchanges from the applicable last interest payment date to, but not including, March 28, 2016. A total of 25.6 million shares carried a conversion price of $3.11 pursuant to the existing terms of the Notes. $79.2 million of the Notes remain outstanding as of March 31, 2016.





RESULTS OF OPERATIONS

THREE MONTHS ENDED MARCH 31, 2016 AND MARCH 31, 2015

We had no revenues during the three months ended March 31, 2016 and three corresponding months in 2015 because we do not have any commercial biopharmaceutical products.

Research and development expenses for the three months ended March 31, 2016 (“Current Year Quarter”) increased approximately $3 million or 16%, to approximately $21.2 million from approximately $18.2 million for the three months ended March 31, 2015 (“Prior Year Quarter”). This increase in research and development expenses was due primarily to greater spending on IBS-C studies and fees related to our NDA filing, offset partially by a reduction in clinical trials.

The following table sets forth our research and development expenses directly related to our product candidates, as well as indirect costs, for the three months ended March 31, 2016 and 2015. Direct expenses include external costs associated with chemistry, manufacturing and controls including costs of drug substance and product formulation, as well as preclinical studies

18

and clinical trial costs. Indirect research and development costs include in-house staff compensation, facilities, depreciation, stock-based compensation and research and development support services not directly allocated to specific drug candidates.

 
($ in thousands)
Three Months Ended
March 31,
 
2016
 
2015
Plecanatide
$
18,200

 
$
14,640

Dolcanatide
472

 
1,539

Total direct costs
18,672

 
16,179

Total indirect costs
2,503

 
2,019

Total Research and Development
$
21,175

 
$
18,198


Indirect research and development costs are comprised of in-house staff compensation, facilities, depreciation, stock-based compensation and research and development support services are not directly allocated to specific drug candidates. Indirect costs were approximately $2.5 million in the Current Year, as compared to approximately $2 million during the Prior Year representing an increase of $0.5 million which were primarily due to higher stock based compensation and employee compensation expenses. Higher compensation is related to staffing and other pre-production activities related to the commercial launch of plecanatide next year.

Selling, general and administrative expenses increased $1.8 million or 39%, to $6.4 million for the Current Quarter from approximately $4.6 million for the Prior Quarter. These increased expenses were primarily a result of higher spending in preparation of our commercial launch next year, including approximately a $1.8 million increase in marketing expenses, a $0.7 million increase in consulting and $0.6 million increase in employee compensation, partially offset by approximately $1.5 million decrease in stock compensation expense.

Net loss for the Current Year Quarter was $59.9 million as compared to a net loss of a $27.4 million incurred for the Prior Year Quarter. In addition to the operating items discussed above, this increase in our net loss of $32.5 million or 118% was primarily a result of debt conversion expense of approximately $25.6 million resulting from our March 2016 convertible notes Exchange.

LIQUIDITY AND CAPITAL RESOURCES

As of March 31, 2016, we had approximately $84.2 million in cash and cash equivalents, compared to approximately $111.8 million in cash, cash equivalents and available for sale securities as of December 31, 2015. Net cash used in operating activities was $27.6 million for the three months ended March 31, 2016 and $23.1 million for the three months ended March 31, 2015.  As of March 31, 2016, we had working capital of $68.3 million, as compared to working capital of $95.5 million on December 31, 2015.

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.

We will be required to raise additional capital to continue the development and commercialization of current product candidates and to continue to fund operations at the current cash expenditure levels. We cannot be certain that additional funding will be available on acceptable terms, or at all. Recently worldwide economic conditions and the international equity and credit markets have significantly deteriorated and may remain difficult for the foreseeable future. These developments may make it more difficult to obtain additional equity or credit financing, when needed. To the extent that we raise additional funds by issuing equity securities, our stockholders may experience significant dilution. Any debt financing, if available, may involve restrictive covenants that impact our ability to (i) conduct, delay, scale back or discontinue the development and/or commercialization of one or more product candidates; (ii) seek collaborators for product candidates at an earlier stage than otherwise would be desirable and on terms that are less favorable than might otherwise be available; or (iii) relinquish or otherwise dispose of rights to technologies, product candidates or products that we would otherwise seek to develop or commercialize ourselves on unfavorable terms.


19

Our consolidated financial statements as of December 31, 2015 and our condensed consolidated financial statements as of March 31, 2016 have been prepared under the assumption that we will continue as a going concern for the next twelve months. Our independent registered public accounting firm has issued a report as of December 31, 2015 that includes an explanatory paragraph referring to our recurring and continuing losses from operations and expressing substantial doubt in our ability to continue as a going concern without additional capital becoming available. Our ability to continue as a going concern is dependent upon our ability to obtain additional equity or debt financing, attain further operating efficiencies, reduce expenditures, and, ultimately, to generate revenue. Our consolidated financial statements as of December 31, 2015 and our condensed consolidated financial statements as of March 31, 2016 do not include any adjustments that might result from the outcome of this uncertainty.


CRITICAL ACCOUNTING POLICIES

Financial Reporting Release No. 60 requires all companies to include a discussion of critical accounting policies or methods used in the preparation of financial statements. Our accounting policies are described in ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA of our Annual Report on Form 10-K as of and for year ended December 31, 2015, filed with the SEC on February 25, 2016. There have been no other changes to our critical accounting policies since December 31, 2015.



OFF-BALANCE SHEET ARRANGEMENTS

We had no off-balance sheet arrangements as of March 31, 2016.

ITEM 3.                QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Our exposure to market risk on the fair values of certain assets is related to credit risk associated with bank checking accounts and securities held in money market mutual funds  As of March 31, 2016, we held $84.2 million in checking and money market mutual funds and available-for-sale securities. Our cash and cash equivalents balances are in excess of Federally insured limits.  We believe our cash, cash equivalents and available-for-sale securities do not contain excessive risk, however we cannot provide absolute assurance that in the future our investments will not be subject to adverse changes in market value.

ITEM 4.                CONTROLS AND PROCEDURES

Based on an evaluation of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) of the Securities Exchange Act of 1934, as amended) required by paragraph (b) of Rule 13a-15 or Rule 15d-15, our Chief Executive Officer and Principal Financial Officer have concluded that as of March 31, 2016, our disclosure controls and procedures were effective in ensuring that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Commission’s rules and forms. Disclosure controls and procedures include, without limitations, controls and procedures designed to ensure that information required to be disclosed by us in the reports we file under the Exchange Act is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

CHANGES IN INTERNAL CONTROL OVER FINANCIAL REPORTING

As required by Rule 13a-15(d) of the Exchange Act, our management, including our Chief Executive Officer and our Principal Financial Officer, conducted an evaluation of the internal control over financial reporting to determine whether any changes occurred during the period covered by this Quarterly Report on Form 10-Q that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting. Based on that evaluation, our Chief Executive Officer and Principal Financial Officer concluded there were no changes in our internal controls over financial

20

reporting (as defined in Rule 13a-15(f) under the Exchange Act) that could significantly affect internal controls over financial reporting during the quarter ended March 31, 2016.


21

PART II. OTHER INFORMATION

ITEM 1.                 LEGAL PROCEEDINGS

There have been no material changes from the legal proceedings disclosed in our Form 10-K for the year ended December 31, 2015, filed on February 25, 2016.

ITEM 1a.               RISK FACTORS

There have been no material changes in our risk factors since the filing on February 25, 2016 of our Form 10-K for the year ended December 31, 2015.

ITEM 2.                 PROPERTIES

There have been no material changes in our properties since the filing on February 25, 2016 of our Form 10-K for the year ended December 31, 2015.


22

ITEM 6.
EXHIBITS
 
 
(a)
Exhibits
 
 
10.1
Form of Exchange Agreement Related to 7.50% Convertible Senior Notes (incorporated by reference to Exhibit 99.1 to Form 8-K filed on March 18, 2016).
 
 
31.1
Certification of Chief Executive Officer required under Rule 13a-14(a)/15d-14(a) under the Exchange Act.
 
 
31.2
Certification of Principal Financial Officer required under Rule 13a-14(a)/15d-14(a) under the Exchange Act.
 
 
32.1
Certification of Chief Executive Officer pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
 
 
32.2
Certification of Principal Financial Officer pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
 
 
101
Financial statements from the quarterly report on Form 10-Q of the Company for the quarter ended March 31, 2016, filed on May 10, 2016, formatted in Extensible Business Reporting Language (XBRL): (i) the Condensed Consolidated Statements of Operations, (ii) the Condensed Consolidated Balance Sheets, (iii) the Condensed Consolidated Statement of Stockholders Equity (iv) the Condensed Consolidated Statements of Cash Flows and (v) the Notes to Consolidated Financial Statements tagged as blocks of text.


23

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 
SYNERGY PHARMACEUTICALS INC.
 
(Registrant)
 
 
 
Date: May 10, 2016
By:
/s/ GARY S. JACOB
 
 
Gary S. Jacob
 
 
President, Chairman of Board, and Chief Executive Officer
 
 
 
Date: May 10, 2016
By:
/s/ BERNARD F. DENOYER
 
 
Bernard F. Denoyer
 
 
Senior Vice President, Finance and Principal Financial Officer

24


EXHIBIT 31.1
 
CERTIFICATIONS
 
I, Gary S. Jacob, certify that:
 
1)                                      I have reviewed this report on Form 10-Q of Synergy Pharmaceuticals Inc.
 
2)                                      Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
 
3)                                      Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
 
4)                                      The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and we have:
 
a)                                      Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
 
b)                                      Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
 
c)                                       Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
 
d)                                      Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
 
5)                                      The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions);
 
a)                                      All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
 
b)                                      Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
 

Date: May 10, 2016
/s/ GARY S. JACOB
 
Gary S. Jacob
 
President, Chairman of Board, and Chief Executive Officer
 


25


EXHIBIT 31.2
 
CERTIFICATIONS
 
I, Bernard F. Denoyer, certify that:
 
1)                                      I have reviewed this report on Form 10-Q of Synergy Pharmaceuticals Inc.
 
2)                                      Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
 
3)                                      Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
 
4)                                      The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and we have:
 
a)                                      Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
 
b)                                      Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
 
c)                                       Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
 
d)                                      Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
 
5)                                      The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions);
 
a)                                      All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
 
b)                                      Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
 

Date: May 10, 2016
/s/ BERNARD F. DENOYER
 
Bernard F. Denoyer
 
Senior Vice President, Finance and Principal Financial Officer
 


26


EXHIBIT 32.1
 
CERTIFICATION OF CHIEF EXECUTIVE OFFICER
SYNERGY PHARMACEUTICALS INC.
FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2016
PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
 
I am the Chief Executive Officer of Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”). I am delivering this certificate in connection with the Form 10-Q of the Company for the quarter ended March 31, 2016 and filed with the Securities and Exchange Commission (“Form 10-Q”).
 
Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I hereby certify that, to the best of my knowledge, the Form 10-Q fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
 

Date: May 10, 2016
/s/ GARY S. JACOB
 
Gary S. Jacob
 
President, Chairman of Board, and Chief Executive Officer
 


EXHIBIT 32.2

27


 
CERTIFICATION OF SENIOR VICE PRESIDENT, FINANCE
SYNERGY PHARMACEUTICALS INC.
FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2016
PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
 
I am the Senior Vice President, Finance of Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”). I am delivering this certificate in connection with the Form 10-Q of the Company for the quarter ended March 31, 2016 and filed with the Securities and Exchange Commission (“Form 10-Q”).
 
Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I hereby certify that, to the best of my knowledge, the Form 10-Q fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
 

Date: May 10, 2016
/s/ BERNARD F. DENOYER
 
Bernard F. Denoyer
 
Senior Vice President, Finance and Principal Financial Officer


28


EXHIBIT 31.1
 
CERTIFICATIONS
 
I, Gary S. Jacob, certify that:
 
1)                    I have reviewed this report on Form 10-Q of Synergy Pharmaceuticals Inc.
 
2)                    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
 
3)                    Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
 
4)                    The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and we have:
 
a)                    Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
 
b)                    Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
 
c)                     Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
 
d)                    Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
 
5)                    The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions);
 
a)                    All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
 
b)                    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
Date:
May 10, 2016
 
/s/ GARY S. JACOB
 
 
 
Gary S. Jacob
 
 
 
President, Chairman of Board, and Chief Executive Officer





EXHIBIT 31.2
 
CERTIFICATIONS
 
I, Bernard F. Denoyer, certify that:
 
1)                    I have reviewed this report on Form 10-Q of Synergy Pharmaceuticals Inc.
 
2)                    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
 
3)                    Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
 
4)                    The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and we have:
 
a)                    Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
 
b)                    Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
 
c)                     Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
 
d)                    Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
 
5)                    The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions);
 
a)                    All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
 
b)                    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
Date:
May 10, 2016
 
/s/ BERNARD F. DENOYER
 
 
 
Bernard F. Denoyer
 
 
 
Senior Vice President, Finance





EXHIBIT 32.1
 
CERTIFICATION OF CHIEF EXECUTIVE OFFICER

SYNERGY PHARMACEUTICALS INC.

FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2016

PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED

PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
 
I am the Chief Executive Officer of Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”). I am delivering this certificate in connection with the Form 10-Q of the Company for the quarter ended March 31, 2016 and filed with the Securities and Exchange Commission (“Form 10-Q”).
 
Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I hereby certify that, to the best of my knowledge, the Form 10-Q fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
Date:
May 10, 2016
/s/ GARY S. JACOB
 
 
Gary S. Jacob
 
 
President, Chairman of Board, and Chief Executive Officer





EXHIBIT 32.2
 
CERTIFICATION OF SENIOR VICE PRESIDENT, FINANCE

SYNERGY PHARMACEUTICALS INC.

FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2016

PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED

PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
 
I am the Senior Vice President, Finance of Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”). I am delivering this certificate in connection with the Form 10-Q of the Company for the quarter ended March 31, 2016 and filed with the Securities and Exchange Commission (“Form 10-Q”).
 
Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I hereby certify that, to the best of my knowledge, the Form 10-Q fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
Date:
May 10, 2016
 
/s/ BERNARD F. DENOYER
 
 
 
Bernard F. Denoyer
 
 
 
Senior Vice President, Finance



v3.4.0.3
Document and Entity Information - shares
 3 Months Ended
Mar. 31, 2016
May. 10, 2016
Document and Entity Information    
Entity Registrant Name SYNERGY PHARMACEUTICALS, INC.  
Entity Central Index Key 0001347613  
Current Fiscal Year End Date --12-31  
Entity Current Reporting Status Yes  
Entity Filer Category Accelerated Filer  
Document Type 10-Q  
Document Period End Date Mar. 31, 2016  
Document Fiscal Year Focus 2016  
Document Fiscal Period Focus Q1  
Amendment Flag false  
Entity Common Stock, Shares Outstanding   179,776,089
v3.4.0.3
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($)
Mar. 31, 2016
Dec. 31, 2015
Current Assets:    
Cash and cash equivalents $ 84,155,000 $ 61,653,000
Available-for-sale securities 0 50,097,000
Prepaid expenses and other current assets 3,361,000 3,305,000
Total Current Assets 87,516,000 115,055,000
Property and equipment, net 534,000 531,000
Security deposits 343,000 343,000
Total Assets 88,393,000 115,929,000
Current Liabilities:    
Accounts payable 13,561,000 13,263,000
Accrued expenses 3,229,000 4,328,000
Interest payable on Senior Convertible Debentures 2,474,000 1,988,000
Total Current Liabilities 19,264,000 19,579,000
Senior Convertible Notes, net of deferred financing costs of $3,617 and $7,769 as of March 31, 2016 and December 31, 2015, respectively 75,565,000 151,241,000
Derivative financial instruments, at estimated fair value-warrants 62,000 322,000
Total Liabilities $ 94,891,000 $ 171,142,000
Commitments and contingencies
Stockholders’ Deficit:    
Preferred stock, Authorized 20,000,000 shares and none outstanding, at March 31, 2016 and December 31, 2015 $ 0 $ 0
Common stock, par value of $.0001, 350,000,000 shares authorized at March 31, 2016 and December 31, 2015. Issued and outstanding 149,821,088 shares and 113,694,606 shares at March 31, 2016 and December 31, 2015, respectively. 15,000 11,000
Additional paid-in capital 437,813,000 329,161,000
Accumulated deficit (444,326,000) (384,385,000)
Total Stockholders’ Deficit (6,498,000) (55,213,000)
Total Liabilities and Stockholders’ Deficit $ 88,393,000 $ 115,929,000
v3.4.0.3
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($)
$ in Thousands
Mar. 31, 2016
Dec. 31, 2015
Statement of Financial Position [Abstract]    
Deferred financing costs $ 3,617 $ 7,769
Preferred stock, authorized shares (in shares) 20,000,000 20,000,000
Preferred stock, outstanding shares (in shares) 0 0
Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001
Common stock, shares authorized (in shares) 350,000,000 350,000,000
Common stock, issued shares (in shares) 149,821,088 113,694,606
Common stock, outstanding shares (in shares) 149,821,088 113,694,606
v3.4.0.3
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Income Statement [Abstract]    
Revenues $ 0 $ 0
Costs and Expenses:    
Research and development 21,175 18,198
Selling, general and administrative 6,375 4,606
Loss from Operations (27,550) (22,804)
Other Loss    
Interest and investment expense, net (7,036) (4,317)
Debt conversion expense (25,615) 0
Change in fair value of derivative instruments-warrants 260 (268)
Total Other Loss (32,391) (4,585)
Net Loss $ (59,941) $ (27,389)
Weighted Average Common Shares Outstanding    
Basic and Diluted (in shares) 117,626,669 96,683,525
Net Loss per Common Share, Basic and Diluted    
Net Loss per Common Share, Basic and Diluted (in dollars per share) $ (0.51) $ (0.28)
v3.4.0.3
CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT - 3 months ended Mar. 31, 2016 - USD ($)
$ in Thousands
Total
Common Shares
Additional Paid in Capital
Deficit Accumulated
Balance, January 1, 2016 at Dec. 31, 2015 $ (55,213) $ 11 $ 329,161 $ (384,385)
Balance, January 1, 2016 (in shares) at Dec. 31, 2015 113,694,606 113,694,606    
Increase (Decrease) in Stockholders' Equity        
Notes conversions including shares issued for accrued interest $ 82,274 $ 3 82,271  
Notes conversions including shares issued for accrued interest (in shares)   26,532,731    
Debt conversion expense 25,615 $ 1 25,614  
Debt conversion expense (in shares)   9,593,751    
Transaction fees on Note conversions (435)   (435)  
Stock based compensation expense 1,202   1,202  
Net loss for the period (59,941)     (59,941)
Balance, March 31, 2016 at Mar. 31, 2016 $ (6,498) $ 15 $ 437,813 $ (444,326)
Balance, March 31, 2016 (in shares) at Mar. 31, 2016 149,821,088 149,821,088    
v3.4.0.3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Cash Flows From Operating Activities:    
Net loss $ (59,941) $ (27,389)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 38 34
Amortization of deferred financing costs 4,153 617
Stock-based compensation expense $ 1,202 2,405
Accretion of discount/premium on available for sale securities (13)
Change in fair value of derivative instruments—warrants $ (260) 268
Common stock issued for interest on Notes 2,445 0
Debt conversion expense 25,615 0
Transaction fees on Note conversions (435) 0
Changes in operating assets and liabilities:    
Security deposit 0 (56)
Accounts payable and accrued expenses (800) (2,952)
Prepaid expenses and other current assets (56) 187
Accrued interest expense on Senior Convertible Debentures 487 3,750
Total Adjustments 32,389 4,240
Net Cash used in Operating Activities (27,552) (23,149)
Cash Flows From Investing Activities:    
Net sales (purchases) of available-for-sale securities 50,097 (50,000)
Additions to property and equipment (43) (8)
Net Cash provided by (used in) Investing Activities 50,054 (50,008)
Cash Flows From Financing Activities:    
Proceeds of sale of common stock 0 5,558
Fees and expenses — sale of common stock 0 (153)
Net Cash provided by Financing Activities 0 5,405
Net increase (decrease) in cash and cash equivalents 22,502 (67,752)
Cash and cash equivalents at beginning of period 61,653 146,470
Cash and cash equivalents at end of period 84,155 78,718
Supplementary disclosure of cash flow information:    
Cash paid for taxes 45 122
Supplementary disclosure of non-cash investing and financing activities:    
Conversion of Senior Convertible Debentures to Synergy Common Stock $ 82,274 $ 0
v3.4.0.3
Business Overview
 3 Months Ended
Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Business Overview
Business Overview

Synergy Pharmaceuticals Inc. (the “Company” or ‘Synergy”) is a biopharmaceutical company focused on the development and commercialization of novel gastrointestinal (GI) therapies. Since the Company’s inception in 2008, it has pioneered discovery, research and development efforts in the treatment of functional GI disorders and inflammatory bowel disease (IBD). Synergy's proprietary GI platform is based on uroguanylin, a naturally occurring human GI peptide, and includes two lead product candidates - plecanatide and dolcanatide.

Net cash used in operating activities was approximately $27.6 million for the three months ended March 31, 2016. As of March 31, 2016, Synergy had approximately $84.2 million of cash and cash equivalents. During the three months ended March 31, 2016, Synergy incurred losses from operations of $27.6 million. As of March 31, 2016, Synergy had working capital of approximately $68.3 million.

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.
v3.4.0.3
Basis of Presentation
 3 Months Ended
Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Basis of Presentation
Basis of Presentation

These unaudited condensed consolidated financial statements include Synergy and its wholly-owned subsidiaries:  (1) Synergy Advanced Pharmaceuticals, Inc., (2) IgX, Ltd (Ireland—inactive). These unaudited condensed consolidated financial statements have been prepared following the requirements of the Securities and Exchange Commission (“SEC”) and United States generally accepted accounting principles (“GAAP”) for interim reporting. In the opinion of management, the accompanying unaudited condensed consolidated financial statements include all adjustments, which include only normal recurring adjustments, necessary to present fairly Synergy’s interim financial information. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2015 contained in the Company’s Annual Report on Form 10-K filed with the SEC on February 25, 2016. All intercompany balances and transactions have been eliminated.

Synergy will be required to raise additional capital within the next year to continue the development and commercialization of current product candidates and to continue to fund operations at the current cash expenditure levels. Synergy cannot be certain that additional funding will be available on acceptable terms, or at all. To the extent that Synergy raises additional funds by issuing equity securities, Synergy’s stockholders may experience significant dilution. Any debt financing, if available, may involve restrictive covenants that impact Synergy’s ability to conduct business. If Synergy is unable to raise additional capital when required or on acceptable terms, Synergy may have to (i) significantly delay, scale back or discontinue the development and/or commercialization of one or more product candidates; (ii) seek collaborators for product candidates at an earlier stage than otherwise would be desirable and on terms that are less favorable than might otherwise be available; or (iii) relinquish or otherwise dispose of rights to technologies, product candidates or products that Synergy would otherwise seek to develop or commercialize ourselves on unfavorable terms.
Synergy's consolidated financial statements as of December 31, 2015 and its condensed consolidated financial statements as of March 31, 2016 have been prepared under the assumption that it will continue as a going concern for the next twelve months. Its independent registered public accounting firm has issued a report as of December 31, 2015 that includes an explanatory paragraph referring to the Company's recurring and continuing losses from operations and expressing substantial doubt in the Company's ability to continue as a going concern without additional capital becoming available. Synergy's ability to continue as a going concern is dependent upon its ability to obtain additional equity or debt financing, attain further operating efficiencies, reduce expenditures, and, ultimately, to generate revenue. Synergy's consolidated financial statements as of December 31, 2015 and its condensed consolidated financial statements as of March 31, 2016 do not include any adjustments that might result from the outcome of this uncertainty.
v3.4.0.3
Recent Accounting Pronouncements
 3 Months Ended
Mar. 31, 2016
New Accounting Pronouncements and Changes in Accounting Principles [Abstract]  
Recent Accounting Pronouncements
Recent Accounting Pronouncements

In March 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2016-09, “Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting” (“ASU 2016-09”). The standard is intended to simplify several areas of accounting for share-based compensation arrangements, including the income tax impact, classification on the statement of cash flows and forfeitures. ASU 2016-09 is effective for fiscal years, and interim periods within those years, beginning after December 15, 2016, and early adoption is permitted. The Company is currently evaluating the impact that the standard will have on its condensed consolidated financial statements.

In February 2016, the FASB issued ASU 2016-02 “Leases (Topic 842)” (“ASU 2016-02”). The FASB issued ASU 2016-02 to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities on the balance sheet and disclosing key information about leasing arrangements. Under ASU 2016-02, a lessee will recognize in the statement of financial position a liability to make lease payments (the lease liability) and a right-to-use asset representing its right to use the underlying asset for the lease term. The recognition, measurement, and presentation of expenses and cash flows arising from a lease by a lessee have not significantly changed from current GAAP. ASU 2016-02 retains a distinction between finance leases (i.e. capital leases under current GAAP) and operating leases. The classification criteria for distinguishing between finance leases and operating leases will be substantially similar to the classification criteria for distinguishing between capital leases and operating leases under current GAAP. The amendments of this ASU are effective for reporting periods beginning after December 15, 2018, with early adoption permitted. An entity will be required to recognize and measure leases at the beginning of the earliest period presented using a modified retrospective approach. Management is currently assessing the impact the adoption of ASU 2016-02 will have on its Financial Statements.

In January 2016, the FASB issued ASU 2016-01, "Financial Instruments—Overall (Topic 825-10): "Recognition and Measurement of Financial Assets and Financial Liabilities." ASU 2016-01 amends the guidance on the classification and measurement of financial instruments. Some of the amendments in ASU 2016-01 include the following: 1) requires equity investments (except those accounted for under the equity method of accounting or those that result in consolidation of the investee) to be measured at fair value with changes in fair value recognized in net income; 2) simplifies the impairment assessment of equity investments without readily determinable fair values by requiring a qualitative assessment to identify impairment; 3) requires public business entities to use the exit price notion when measuring the fair value of financial instruments for disclosure purposes; and 4) requires an entity to present separately in other comprehensive income the portion of the total change in the fair value of a liability resulting from a change in the instrument-specific credit risk when the entity has elected to measure the liability at fair value; among others. For public business entities, the amendments of ASU 2016-01 are effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures, if any.

In April 2015, the FASB issued ASU No. 2015-03 Simplifying the Presentation of Debt Issuance Costs, which changes the presentation of debt issuance costs in the financial statements. Under the standard, debt issuance costs are presented in the balance sheet as a direct deduction from the related debt liability rather than as an asset. In addition amortization of debt issuance costs are to be combined with interest expense in the statement of operations. The guidance is effective for annual and interim reporting periods beginning after December 15, 2015. The Company adopted this guidance during the quarter ended June 30, 2015. (See Note 5)

In August 2014, the FASB issued Accounting Standards Update (“ASU”) No. 2014-15, “Presentation of Financial Statements - Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern.” This ASU provides guidance on management’s responsibility to evaluate whether there is substantial doubt about an entity’s ability to continue as a going concern or to provide related footnote disclosures. The amendments require management to assess an entity’s ability to continue as a going concern by incorporating and expanding upon certain principles that are currently in U.S. auditing standards. The new standard will be effective for annual periods ending after December 15, 2016, and interim periods within annual periods beginning after December 15, 2016. Early adoption is permitted. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures.
v3.4.0.3
Cash, Cash Equivalents and Available-for-sale Securities
 3 Months Ended
Mar. 31, 2016
Cash, Cash Equivalents, and Short-term Investments [Abstract]  
Cash, Cash Equivalents and Available-for-sale Securities
Cash, Cash Equivalents and Available-for-sale Securities

All highly liquid investments with maturities of three months or less at the date of purchase are classified as cash equivalents. As of March 31, 2016 and December 31, 2015, the amount of cash and cash equivalents was $84.2 million and $61.7 million, respectively and consists of checking accounts and short-term money market mutual funds. Checking accounts are held at U.S. commercial banks, and balances were in excess of the FDIC insurance limit.

The Company had no available-for-sale securities as of March 31, 2016 and $50.1 million of available-for-sale securities as of December 31, 2015. Management determines the appropriate classification of its investments at the time of purchase and reevaluates the available-for-sale designations as of each balance sheet date.
v3.4.0.3
Senior Convertible Notes
 3 Months Ended
Mar. 31, 2016
Debt Disclosure [Abstract]  
Senior Convertible Notes
Senior Convertible Notes

On November 3, 2014, Synergy closed a private offering of $200 million aggregate principal amount of 7.50% Convertible Senior Notes due 2019 (including the full exercise of the over-allotment option granted to the initial purchasers to purchase an additional $25 million aggregate principal amount of 7.50% Convertible Senior Notes due 2019, (the “Notes”), interest payable semiannually in arrears on May 1 and November 1 of each year, beginning on May 1, 2015. The net proceeds from the offering were $187.3 million after deducting the initial purchasers’ discounts and offering expenses.

The Notes are unsecured. Interest expense not including amortization of deferred financing costs for three months ended March 31, 2016 and 2015 was $0.5 million and $3.8 million, respectively. Accrued interest payable was $2.5 million and $2.0 million as of March 31, 2016 and December 31, 2015 respectively.

A summary of quarterly activity is listed below (dollars in thousands):

Interest payable on Senior Convertible Debenture at 1/1/2015
$
2,500

Accrued interest expense during the 3 months ended March 31, 2015
3,750

Interest Payable on Senior Convertible Debenture at March 31, 2015
6,250

Accrued interest expense during the 3 months ended June 30, 2015
3,388

Interest Payment on Senior Convertible Debenture at May 1, 2015
(7,416
)
Interest payable on Senior Convertible Debenture as of June 30, 2015
2,222

Accrued interest expense during the 3 months ended September 30, 2015
2,747

Interest payable on Senior Convertible Debenture as of September 30, 2015
4,969

Interest payment at November 1, 2015
(5,963
)
Accrued interest expense during the 3 months ended December 31, 2015
2,982

Interest payable as of December 31, 2015
1,988

Accrued interest expense during the 3 months ended March 31, 2016
486

Interest payable as of March 31, 2016
$
2,474



The Notes will mature on November 1, 2019, unless earlier purchased or converted. The Notes are convertible, at any time, into shares of Synergy’s common stock at an initial conversion rate of 321.5434 shares per $1,000 principal amount of notes, which is equivalent to the original conversion price of $3.11 per share. Subsequent to the exchange described above, the principal balance of the Notes at March 31, 2016 is $79.2 million as compared to $159.0 million at December 31, 2015. Transaction costs associated with the sale of the Notes of $12.7 million have been deferred and are being recognized as expense over the expected term of the Notes, calculated using the effective interest rate method. Amortization expense, including amortization associated with reduction of the principal due to the conversion and exchanges of the debentures on a prorated basis for three months ended March 31, 2016 and 2015 was $4.2 million and 0.6 million, respectively. The remaining transaction costs have been presented as a reduction of the Notes in accordance with the newly adopted Accounting Standards Update (“ASU”) No. 2015-3 “Simplifying the Presentation of Debt Issuance Costs”.

On March 18, 2016 Synergy entered into an exchange agreement for the exchange of $79.8 million in aggregate principal amount of the Notes, representing approximately 50% of the outstanding aggregate principal amount of Notes, for 35.3 million shares of Synergy's common stock, with a total of 25.7 million shares representing the conversion price of $3.11 pursuant to the existing terms of the Notes. Synergy also issued approximately 872,000 shares at the five day average share price of $2.81 in payment of accrued and unpaid interest of $2.4 million on Notes accepted in the Exchanges, from the applicable last interest payment date to, but not including, March 28, 2016. The amortization of deferred financing costs was accelerated consistent with the 50% reduction of aggregate principal amount this transaction represented, and resulted in additional interest expense of approximately $3.6 million. GAAP requires that such conversions be treated as induced conversions with an expense recognized equal to the fair value of the securities and other consideration transferred in the transaction in excess of the fair value of the securities issuable pursuant to the original conversion terms, with such fair value being measured as of the date the inducement offer is accepted by the convertible debt holder. Accordingly, the Company recognized a debt conversion expense of $25.6 million for the three months ended March 31, 2016.

A summary of quarterly activity and balances associated with the Notes and related deferred transaction costs is presented below ($ in thousands):

 
Notes Balance
 
Transactions
Costs
 
Notes, net of
Transaction
Costs
Balance at issuance November 1, 2014
$
200,000

 
$
12,747

 
$
187,253

Less: amortization two months ended December 31, 2014
—

 
(411
)
 
411

Balance December 31, 2014
200,000

 
12,336

 
187,664

Less: amortization three months ended March 31, 2015
—

 
(617
)
 
617

Balance March 31, 2015
200,000

 
11,719

 
188,281

Less: amortization three months ended June 30, 2015 (1)
—

 
(1,899
)
 
1,899

Conversions
(22,213
)
 
—

 
(22,213
)
Balance June 30, 2015
177,787

 
9,820

 
167,967

Less: amortization three months ended September 30, 2015 (1)
—

 
(1,544
)
 
1,544

Conversions
(18,776
)
 
—

 
(18,776
)
Balance, September 30, 2015
159,011

 
8,276

 
150,735

Less: amortization three months ended December 31, 2015 
—

 
(506
)
 
506

Balance December 31, 2015
159,011

 
7,770

 
151,241

Less: amortization three months ended March 31, 2016 (1)
—

 
(4,153
)
 
4,153

Conversions
(79,829
)
 
—

 
(79,829
)
Balance, March 31, 2016
$
79,182

 
$
3,617

 
$
75,565

_____________________
(1) Includes accelerated amortization of deferred financing costs attributable to conversions and exchanges
v3.4.0.3
Accounting for Shared-Based Payments
 3 Months Ended
Mar. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Accounting for Shared-Based Payments
Accounting for Shared-Based Payments

Stock Options

ASC Topic 718 “Compensation—Stock Compensation” requires companies to measure the cost of employee services received in exchange for the award of equity instruments based on the estimated fair value of the award at the date of grant. The expense is to be recognized over the period during which an employee is required to provide services in exchange for the award.  Synergy accounts for shares of common stock, stock options and warrants issued to employees based on the fair value of the stock, stock option or warrant, if that value is more reliably measurable than the fair value of the consideration or services received.

The Company accounts for stock options issued and vesting to non-employees in accordance with ASC Topic 505-50 “ Equity -Based Payment to Non-Employees” and accordingly the value of the stock compensation to non-employees is based upon the measurement date as determined at either a) the date at which a performance commitment is reached, or b) at the date at which the necessary performance to earn the equity instruments is complete. Accordingly the fair value of these options is being “marked to market” quarterly until the measurement date is determined.

Synergy adopted the 2008 Equity Compensation Incentive Plan (the “Plan”) during the quarter ended September 30, 2008. Stock options granted under the Plan typically vest after three years of continuous service from the grant date and have a contractual term of ten years. On June 8, 2015, Synergy amended its 2008 Equity Compensation Incentive Plan and increased the number of shares of its common stock reserved for issuance under the Plan from 15,000,000 to 30,000,000.

Stock-based compensation has been recognized in operating results as follows:

 
 
Three Months Ended
March 31,
($ in thousands)
 
2016
 
2015
Employees—included in research and development
 
810

 
530

Employees—included in general and administrative
 
392

 
1,875

Total stock-based compensation expense
 
$
1,202

 
$
2,405



The unrecognized compensation cost related to non-vested stock options outstanding at March 31, 2016, net of expected forfeitures, was approximately $16.3 million to be recognized over a weighted-average remaining vesting period of approximately 1.94 years. This unrecognized compensation cost does not include amounts related to 4,319,000 shares of stock options which vest and will be measured upon a change of control.

The estimated fair value of stock option awards was determined on the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions during the periods indicated.

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Risk-free interest rate
1.47%-1.74%

 
1.46%-2.02%

Dividend yield
—

 
—

Expected volatility
60
%
 
57
%
Expected term (in years)
6 years

 
6-9.3 years



A summary of stock option activity and of changes in stock options outstanding under the Plan is presented below:

 
Number of
Options
 
Exercise Price
Per Share
 
Weighted Average
Exercise Price
Per Share
 
Intrinsic
Value
(in thousands)
 
Weighted Average
Remaining
Contractual Term
Balance outstanding, December 31, 2015 (1)
20,953,375

 
$0.44-9.12
 
$
3.86

 
$
42,438

 
7.15 years
Granted
405,000

 
$3.12-4.14
 
4.00

 
—

 

Exercised
—

 
0
 
—

 
—

 

Forfeited
(130,427
)
 
$6-9.12
 
6.65

 
—

 

Balance outstanding, March 31, 2016 (1)
21,227,948

 
0.44-9.12
 
$
3.83

 
$
—

 
7.00 years
Exercisable, at March 31, 2016
9,991,733

 
0.44-9.12
 
$
3.30

 
$
4,347

 
5.82 years
__________________________
(1)   Number of options represented above includes 2,159,500 options vesting upon a change of control, granted between November 20, 2009 and June 22, 2010. The fair value at the date of grant was approximately $28.6 million. Because the probability of a change of control transaction is not predictable no stock based compensation expense associated with these options has been recognized since the grant date.
v3.4.0.3
Stockholders' Deficit
 3 Months Ended
Mar. 31, 2016
Stockholders' Equity Note [Abstract]  
Stockholders' Deficit
Stockholders’ Deficit

On March 18, 2016 Synergy entered into an exchange agreement (the "Exchange") for the exchange of $79.8 million in aggregate principal amount of the Notes, representing approximately 50% of the outstanding aggregate principal amount of Notes, for 35.3 million shares of its common stock (the “Shares”), with a total of 25.7 million shares representing the conversion price of $3.11 pursuant to the existing terms of the Notes. Synergy also issued approximately 872,000 shares at the five day average share price of $2.81 in payment of accrued and unpaid interest of $2.4 million on Notes accepted in the Exchanges.

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share. The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016.
v3.4.0.3
Research and Development Expense
 3 Months Ended
Mar. 31, 2016
Research and Development [Abstract]  
Research and Development Expense
Research and Development Expense

Research and development costs include expenditures in connection with an in-house research and development laboratory, salaries and staff costs, application and filing for regulatory approval of proposed products, purchased in-process research and development, regulatory and scientific consulting fees, as well as contract research, patient costs, drug formulation and tableting, data collection, monitoring, and clinical insurance.

In accordance with FASB ASC Topic 730-10-55, Research and Development, Synergy recorded prepaid research and development costs of approximately $2.8 million as of March 31, 2016 and $3.1 million as of December 31, 2015, for nonrefundable pre-payments for production of drug substance and analytical testing services for its drug candidates. In accordance with this guidance, Synergy expenses these costs when drug compound is delivered and services are performed.
v3.4.0.3
Derivative Financial Instruments
 3 Months Ended
Mar. 31, 2016
Derivative Instruments and Hedging Activities Disclosure [Abstract]  
Derivative Financial Instruments
Derivative Financial Instruments

Synergy Derivative Financial Instruments

Effective January 1, 2009, the Company adopted provisions of ASC Topic 815-40, “Derivatives and Hedging: Contracts in Entity’s Own Equity” (“ASC Topic 815-40”). ASC Topic 815-40 clarifies the determination of whether an instrument issued by an entity (or an embedded feature in the instrument) is indexed to an entity’s own stock, which would qualify as a scope exception under ASC Topic 815-10.

Based upon the Company’s analysis of the criteria contained in ASC Topic 815-40, Synergy has determined that certain warrants issued in connection with sale of its common stock must be classified as derivative instruments. In accordance with ASC Topic 815-40, these warrants are also being re-measured at each balance sheet date based on estimated fair value, and any resultant changes in fair value are being recorded in the Company’s statement of operations. The Company estimates the fair value of certain warrants using the Black-Scholes option pricing model in order to determine the associated derivative instrument liability and change in fair value described above. The range of assumptions used to determine the fair value of the warrants at each period end was:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Fair value of Synergy common stock
$
2.76

 
$
4.62

Expected warrant term
1.9

 
0.25-2.9 years

Risk-free interest rate
0.80
%
 
0.03%-0.89%

Expected volatility
60
%
 
57
%
Dividend yield
—

 
—



Fair value of stock is the closing market price of the Company’s common stock at the end of each reporting period when the derivative instruments are marked to market. Expected volatility is a management estimate of future volatility, over the expected warrant term, based on historical volatility of Synergy’s common stock. The warrants have a transferability provision and based on guidance provided in SAB 107 for instruments issued with such a provision, Synergy used the full contractual term as the expected term of the warrants. The risk free rate is based on the U.S. Treasury security rates for maturities consistent with the expected remaining term of the warrants at the date quarterly revaluation.

The following table sets forth the components of changes in the Synergy’s outstanding warrants which were deemed derivative financial instruments and the associated liability balance for the periods indicated:

Date
 
Description
 
Warrants
 
Derivative
Instrument
Liability
(in thousands)
12/31/2015
 
Balance of derivative financial instruments liability
 
210,000

 
$
322

3/31/2016
 
Change in fair value of warrants during the quarter
 
—

 
(260
)
3/31/2016
 
Balance of derivative financial instruments liability
 
210,000

 
$
62
v3.4.0.3
Fair Value Measurements
 3 Months Ended
Mar. 31, 2016
Fair Value Disclosures [Abstract]  
Fair Value Measurements
Fair Value Measurements

Financial instruments consist of cash and cash equivalents, marketable securities, accounts payable and derivative instruments. These financial instruments are stated at their respective historical carrying amounts, which approximate fair value due to their short term nature, except for marketable securities and derivative instruments which are marked to market at the end of each reporting period.

The value of Senior Convertible Notes is stated at its carrying value at March 31, 2016. The Company believes it could obtain borrowings at March 31, 2016 at comparable interest rates as the November 2014 Notes, therefore, the carrying value approximates fair value.

The following table presents the Company’s liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of December 31, 2015 and March 31, 2016

($ in thousands)

Description
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
December 31, 2015
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
—

 
$
—

 
$
322

 
$
322

 
$
—

 
$
—

 
$
62

 
$
62



The following table sets forth a summary of changes in the fair value of the Company’s Level 3 liabilities for the nine months ended March 31, 2016:

($ in thousands)

Description
 
Balance as of
December 31, 2015
 
(Gain) or loss
recognized in
earning from
Change in Fair
Value
 
Expiration of
warrants
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
322

 
$
(260
)
 
$
—

 
$
62



The unrealized gains or losses on the derivative liabilities are recorded as a change in fair value of derivative liabilities in the Company’s statement of operations. A financial instrument’s level within the fair value hierarchy is based on the lowest level of any input that is significant to the fair value measurement. At each reporting period, Synergy reviews the assets and liabilities that are subject to ASC Topic 815-40. At each reporting period, all assets and liabilities for which the fair value measurement is based on significant unobservable inputs or instruments which trade infrequently and therefore have little or no price transparency are classified as Level 3.
v3.4.0.3
Loss per Share
 3 Months Ended
Mar. 31, 2016
Earnings Per Share [Abstract]  
Loss per Share
Loss per Share

Basic and diluted net loss per share is presented in conformity with ASC Topic 260, Earnings per Share, (“ASC Topic 260”) for periods presented. In accordance with ASC Topic 260, basic and diluted net loss per common share was determined by dividing net loss applicable to common stockholders by the weighted-average common shares outstanding during the period. Diluted weighted-average shares are the same as basic weighted-average shares because shares issuable pursuant to the exercise of stock options and warrants would be antidilutive.

The following table sets forth potential common shares issuable upon the exercise of outstanding options, the exercise of warrants, and the conversion of the Senior Convertible Notes, all of which have been excluded from the computation of diluted weighted average shares outstanding as they would be anti-dilutive, including the impact on dilutive net loss per share of in-the-money warrants as per ASC 260-10-45-35 through ASC 260-10-45-37:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Stock Options
21,227,948

 
16,621,065

Warrants
4,726,823

 
5,951,071

Senior Convertible Notes
25,460,450

 
64,308,682

Total shares issuable upon exercise or conversion
51,415,221

 
86,880,818
v3.4.0.3
Subsequent Events
 3 Months Ended
Mar. 31, 2016
Subsequent Events [Abstract]  
Subsequent Events
Subsequent Events

On May 5, 2016 Synergy announced that it has entered into definitive agreements with certain institutional investors to sell 29,948,334 shares of common stock at a price of $3.00 per share.
The shares were offered and sold directly to institutional investors by the company in a registered direct offering conducted without an underwriter or placement agent. The net proceeds from the offering, after deducting estimated offering expenses, were approximately $89.7 million. The offering closed on May 6, 2016
v3.4.0.3
Basis of Presentation (Policies)
 3 Months Ended
Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Basis of Presentation
These unaudited condensed consolidated financial statements include Synergy and its wholly-owned subsidiaries:  (1) Synergy Advanced Pharmaceuticals, Inc., (2) IgX, Ltd (Ireland—inactive). These unaudited condensed consolidated financial statements have been prepared following the requirements of the Securities and Exchange Commission (“SEC”) and United States generally accepted accounting principles (“GAAP”) for interim reporting. In the opinion of management, the accompanying unaudited condensed consolidated financial statements include all adjustments, which include only normal recurring adjustments, necessary to present fairly Synergy’s interim financial information. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2015 contained in the Company’s Annual Report on Form 10-K filed with the SEC on February 25, 2016. All intercompany balances and transactions have been eliminated
Recent Accounting Pronouncements
In March 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2016-09, “Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting” (“ASU 2016-09”). The standard is intended to simplify several areas of accounting for share-based compensation arrangements, including the income tax impact, classification on the statement of cash flows and forfeitures. ASU 2016-09 is effective for fiscal years, and interim periods within those years, beginning after December 15, 2016, and early adoption is permitted. The Company is currently evaluating the impact that the standard will have on its condensed consolidated financial statements.

In February 2016, the FASB issued ASU 2016-02 “Leases (Topic 842)” (“ASU 2016-02”). The FASB issued ASU 2016-02 to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities on the balance sheet and disclosing key information about leasing arrangements. Under ASU 2016-02, a lessee will recognize in the statement of financial position a liability to make lease payments (the lease liability) and a right-to-use asset representing its right to use the underlying asset for the lease term. The recognition, measurement, and presentation of expenses and cash flows arising from a lease by a lessee have not significantly changed from current GAAP. ASU 2016-02 retains a distinction between finance leases (i.e. capital leases under current GAAP) and operating leases. The classification criteria for distinguishing between finance leases and operating leases will be substantially similar to the classification criteria for distinguishing between capital leases and operating leases under current GAAP. The amendments of this ASU are effective for reporting periods beginning after December 15, 2018, with early adoption permitted. An entity will be required to recognize and measure leases at the beginning of the earliest period presented using a modified retrospective approach. Management is currently assessing the impact the adoption of ASU 2016-02 will have on its Financial Statements.

In January 2016, the FASB issued ASU 2016-01, "Financial Instruments—Overall (Topic 825-10): "Recognition and Measurement of Financial Assets and Financial Liabilities." ASU 2016-01 amends the guidance on the classification and measurement of financial instruments. Some of the amendments in ASU 2016-01 include the following: 1) requires equity investments (except those accounted for under the equity method of accounting or those that result in consolidation of the investee) to be measured at fair value with changes in fair value recognized in net income; 2) simplifies the impairment assessment of equity investments without readily determinable fair values by requiring a qualitative assessment to identify impairment; 3) requires public business entities to use the exit price notion when measuring the fair value of financial instruments for disclosure purposes; and 4) requires an entity to present separately in other comprehensive income the portion of the total change in the fair value of a liability resulting from a change in the instrument-specific credit risk when the entity has elected to measure the liability at fair value; among others. For public business entities, the amendments of ASU 2016-01 are effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures, if any.

In April 2015, the FASB issued ASU No. 2015-03 Simplifying the Presentation of Debt Issuance Costs, which changes the presentation of debt issuance costs in the financial statements. Under the standard, debt issuance costs are presented in the balance sheet as a direct deduction from the related debt liability rather than as an asset. In addition amortization of debt issuance costs are to be combined with interest expense in the statement of operations. The guidance is effective for annual and interim reporting periods beginning after December 15, 2015. The Company adopted this guidance during the quarter ended June 30, 2015. (See Note 5)

In August 2014, the FASB issued Accounting Standards Update (“ASU”) No. 2014-15, “Presentation of Financial Statements - Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern.” This ASU provides guidance on management’s responsibility to evaluate whether there is substantial doubt about an entity’s ability to continue as a going concern or to provide related footnote disclosures. The amendments require management to assess an entity’s ability to continue as a going concern by incorporating and expanding upon certain principles that are currently in U.S. auditing standards. The new standard will be effective for annual periods ending after December 15, 2016, and interim periods within annual periods beginning after December 15, 2016. Early adoption is permitted. The Company is currently evaluating the effects of the ASU 2016-01 on its financial statements and disclosures.
v3.4.0.3
Senior Convertible Notes (Tables)
 3 Months Ended
Mar. 31, 2016
Debt Disclosure [Abstract]  
Schedule of interest activity
A summary of quarterly activity is listed below (dollars in thousands):

Interest payable on Senior Convertible Debenture at 1/1/2015
$
2,500

Accrued interest expense during the 3 months ended March 31, 2015
3,750

Interest Payable on Senior Convertible Debenture at March 31, 2015
6,250

Accrued interest expense during the 3 months ended June 30, 2015
3,388

Interest Payment on Senior Convertible Debenture at May 1, 2015
(7,416
)
Interest payable on Senior Convertible Debenture as of June 30, 2015
2,222

Accrued interest expense during the 3 months ended September 30, 2015
2,747

Interest payable on Senior Convertible Debenture as of September 30, 2015
4,969

Interest payment at November 1, 2015
(5,963
)
Accrued interest expense during the 3 months ended December 31, 2015
2,982

Interest payable as of December 31, 2015
1,988

Accrued interest expense during the 3 months ended March 31, 2016
486

Interest payable as of March 31, 2016
$
2,474
Schedule of activity and balances associated with the Notes and related deferred transaction costs
A summary of quarterly activity and balances associated with the Notes and related deferred transaction costs is presented below ($ in thousands):

 
Notes Balance
 
Transactions
Costs
 
Notes, net of
Transaction
Costs
Balance at issuance November 1, 2014
$
200,000

 
$
12,747

 
$
187,253

Less: amortization two months ended December 31, 2014
—

 
(411
)
 
411

Balance December 31, 2014
200,000

 
12,336

 
187,664

Less: amortization three months ended March 31, 2015
—

 
(617
)
 
617

Balance March 31, 2015
200,000

 
11,719

 
188,281

Less: amortization three months ended June 30, 2015 (1)
—

 
(1,899
)
 
1,899

Conversions
(22,213
)
 
—

 
(22,213
)
Balance June 30, 2015
177,787

 
9,820

 
167,967

Less: amortization three months ended September 30, 2015 (1)
—

 
(1,544
)
 
1,544

Conversions
(18,776
)
 
—

 
(18,776
)
Balance, September 30, 2015
159,011

 
8,276

 
150,735

Less: amortization three months ended December 31, 2015 
—

 
(506
)
 
506

Balance December 31, 2015
159,011

 
7,770

 
151,241

Less: amortization three months ended March 31, 2016 (1)
—

 
(4,153
)
 
4,153

Conversions
(79,829
)
 
—

 
(79,829
)
Balance, March 31, 2016
$
79,182

 
$
3,617

 
$
75,565

_____________________
(1) Includes accelerated amortization of deferred financing costs attributable to conversions and exchanges
v3.4.0.3
Accounting for Shared-Based Payments (Tables)
 3 Months Ended
Mar. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of stock-based compensation expense
Stock-based compensation has been recognized in operating results as follows:

 
 
Three Months Ended
March 31,
($ in thousands)
 
2016
 
2015
Employees—included in research and development
 
810

 
530

Employees—included in general and administrative
 
392

 
1,875

Total stock-based compensation expense
 
$
1,202

 
$
2,405
Schedule of weighted-average assumptions used to estimate fair value of stock option awards using the Black-Scholes option valuation model
The estimated fair value of stock option awards was determined on the date of grant using the Black-Scholes option valuation model with the following weighted-average assumptions during the periods indicated.

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Risk-free interest rate
1.47%-1.74%

 
1.46%-2.02%

Dividend yield
—

 
—

Expected volatility
60
%
 
57
%
Expected term (in years)
6 years

 
6-9.3 years
Summary of stock option activity and of changes in stock options outstanding under the Plan

A summary of stock option activity and of changes in stock options outstanding under the Plan is presented below:

 
Number of
Options
 
Exercise Price
Per Share
 
Weighted Average
Exercise Price
Per Share
 
Intrinsic
Value
(in thousands)
 
Weighted Average
Remaining
Contractual Term
Balance outstanding, December 31, 2015 (1)
20,953,375

 
$0.44-9.12
 
$
3.86

 
$
42,438

 
7.15 years
Granted
405,000

 
$3.12-4.14
 
4.00

 
—

 

Exercised
—

 
0
 
—

 
—

 

Forfeited
(130,427
)
 
$6-9.12
 
6.65

 
—

 

Balance outstanding, March 31, 2016 (1)
21,227,948

 
0.44-9.12
 
$
3.83

 
$
—

 
7.00 years
Exercisable, at March 31, 2016
9,991,733

 
0.44-9.12
 
$
3.30

 
$
4,347

 
5.82 years
__________________________
(1)   Number of options represented above includes 2,159,500 options vesting upon a change of control, granted between November 20, 2009 and June 22, 2010. The fair value at the date of grant was approximately $28.6 million. Because the probability of a change of control transaction is not predictable no stock based compensation expense associated with these options has been recognized since the grant date.
v3.4.0.3
Derivative Financial Instruments (Tables)
 3 Months Ended
Mar. 31, 2016
Derivative Instruments and Hedging Activities Disclosure [Abstract]  
Schedule of range of assumptions used to determine the fair value of the warrants
The range of assumptions used to determine the fair value of the warrants at each period end was:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Fair value of Synergy common stock
$
2.76

 
$
4.62

Expected warrant term
1.9

 
0.25-2.9 years

Risk-free interest rate
0.80
%
 
0.03%-0.89%

Expected volatility
60
%
 
57
%
Dividend yield
—

 
—
Schedule of changes in derivative financial instruments and associated liability balance

The following table sets forth the components of changes in the Synergy’s outstanding warrants which were deemed derivative financial instruments and the associated liability balance for the periods indicated:

Date
 
Description
 
Warrants
 
Derivative
Instrument
Liability
(in thousands)
12/31/2015
 
Balance of derivative financial instruments liability
 
210,000

 
$
322

3/31/2016
 
Change in fair value of warrants during the quarter
 
—

 
(260
)
3/31/2016
 
Balance of derivative financial instruments liability
 
210,000

 
$
62
v3.4.0.3
Fair Value Measurements (Tables)
 3 Months Ended
Mar. 31, 2016
Fair Value Disclosures [Abstract]  
Schedule of liabilities that are measured and recognized at fair value on a recurring basis
The following table presents the Company’s liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of December 31, 2015 and March 31, 2016

($ in thousands)

Description
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
December 31, 2015
 
Quoted Prices
in
Active
Markets
for Identical
Assets and
Liabilities
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
—

 
$
—

 
$
322

 
$
322

 
$
—

 
$
—

 
$
62

 
$
62
Summary of changes in the fair value of Level 3 liabilities
The following table sets forth a summary of changes in the fair value of the Company’s Level 3 liabilities for the nine months ended March 31, 2016:

($ in thousands)

Description
 
Balance as of
December 31, 2015
 
(Gain) or loss
recognized in
earning from
Change in Fair
Value
 
Expiration of
warrants
 
Balance as of
March 31, 2016
Derivative liabilities related to Warrants
 
$
322

 
$
(260
)
 
$
—

 
$
62
v3.4.0.3
Loss per Share (Tables)
 3 Months Ended
Mar. 31, 2016
Earnings Per Share [Abstract]  
Schedule of potential common shares excluded from the computation of diluted weighted average shares outstanding
The following table sets forth potential common shares issuable upon the exercise of outstanding options, the exercise of warrants, and the conversion of the Senior Convertible Notes, all of which have been excluded from the computation of diluted weighted average shares outstanding as they would be anti-dilutive, including the impact on dilutive net loss per share of in-the-money warrants as per ASC 260-10-45-35 through ASC 260-10-45-37:

 
Three Months Ended
March 31, 2016
 
Three Months Ended
March 31, 2015
Stock Options
21,227,948

 
16,621,065

Warrants
4,726,823

 
5,951,071

Senior Convertible Notes
25,460,450

 
64,308,682

Total shares issuable upon exercise or conversion
51,415,221

 
86,880,818
v3.4.0.3
Business Overview (Details)
$ / shares in Units, $ in Thousands
 3 Months Ended
May. 06, 2016
USD ($)
$ / shares
shares
Mar. 31, 2016
USD ($)
item
Mar. 31, 2015
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]          
Number of lead product candidates | item   2      
Net cash (used in) operating activities   $ (27,552) $ (23,149)    
Cash and cash equivalents   84,155 78,718 $ 61,653 $ 146,470
Loss from operations   27,550 22,804    
Working Capital   68,300      
Subsequent Event [Line Items]          
Net proceeds from private placement   $ 0 $ 5,558    
Subsequent Event | Private Placement          
Subsequent Event [Line Items]          
Shares sold in private placement (in shares) | shares 29,948,334        
Shares issued (in dollars per share) | $ / shares $ 3.00        
Net proceeds from private placement $ 89,700        
v3.4.0.3
Cash, Cash Equivalents and Available-for-sale Securities (Details) - USD ($)
Mar. 31, 2016
Dec. 31, 2015
Mar. 31, 2015
Dec. 31, 2014
Cash, Cash Equivalents, and Short-term Investments [Abstract]        
Cash and cash equivalents $ 84,155,000 $ 61,653,000 $ 78,718,000 $ 146,470,000
Available-for-sale securities $ 0 $ 50,097,000    
v3.4.0.3
Senior Convertible Notes - Narrative (Details)
$ / shares in Units, shares in Thousands
 2 Months Ended 3 Months Ended
Mar. 18, 2016
USD ($)
$ / shares
shares
Nov. 03, 2014
USD ($)
$ / shares
Dec. 31, 2014
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Sep. 30, 2015
USD ($)
Jun. 30, 2015
USD ($)
Mar. 31, 2015
USD ($)
Nov. 01, 2014
USD ($)
Debt Instrument [Line Items]                  
Accrued interest payable       $ 2,474,000 $ 1,988,000        
Amortization of deferred financing costs       4,153,000       $ 617,000  
Debt conversion amount       82,274,000       0  
Common stock issued for interest on Notes       2,445,000       0  
Debt conversion expense       25,615,000       0  
Convertible Senior Notes Due 2019                  
Debt Instrument [Line Items]                  
Aggregate principal amount (in dollars)   $ 200,000,000              
Interest rate (as a percent)   7.50%              
Additional aggregate principal amount pertaining to the over-allotment option granted (in dollars)   $ 25,000,000              
Net proceeds from offering (in dollars)   $ 187,300,000              
Accrued interest expense       486,000 2,982,000 $ 2,747,000 $ 3,388,000 3,750,000  
Accrued interest payable     $ 2,500,000 2,474,000 1,988,000 4,969,000 2,222,000 6,250,000  
Conversion rate (as a percent)   0.3215434              
Conversion price (in dollars per share) | $ / shares   $ 3.11              
Notes balance     200,000,000 79,182,000 159,011,000 159,011,000 177,787,000 200,000,000 $ 200,000,000
Transactions costs                 $ 12,700,000
Amortization of deferred financing costs $ 3,600,000   $ 411,000 4,153,000 506,000 1,544,000 1,899,000 $ 617,000  
Debt conversion amount $ 79,800,000     $ 79,829,000   $ 18,776,000 22,213,000    
Percent of principal converted 50.00%                
Number of shares issued on conversion of debt (in shares) | shares 35,300                
Number of shares issued on conversion price excluding share issued for accrued interest (in shares) | shares 25,700                
Number of shares issued for accrued interest (in shares) | shares 872                
Five day average conversion price for accrued interest (in dollars per share) | $ / shares $ 2.81                
Common stock issued for interest on Notes $ 2,400,000                
Interest payment on senior convertible debenture         $ 5,963,000   $ 7,416,000    
v3.4.0.3
Senior Convertible Notes - Schedule of Interest Activity (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Interest Expense Debt [Roll Forward]          
Interest payable on Senior Convertible Debenture, beginning of period $ 1,988        
Interest payable on Senior Convertible Debenture, end of period 2,474 $ 1,988      
Convertible Senior Notes Due 2019          
Interest Expense Debt [Roll Forward]          
Interest payable on Senior Convertible Debenture, beginning of period 1,988 4,969 $ 2,222 $ 6,250 $ 2,500
Accrued interest expense 486 2,982 2,747 3,388 3,750
Interest Payment   (5,963)   (7,416)  
Interest payable on Senior Convertible Debenture, end of period $ 2,474 $ 1,988 $ 4,969 $ 2,222 $ 6,250
v3.4.0.3
Senior Convertible Notes - Schedule of Activity and Balances Associated with the Notes and Related Deferred Transaction Costs (Details) - USD ($)
$ in Thousands
 2 Months Ended 3 Months Ended
Mar. 18, 2016
Dec. 31, 2014
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Convertible Notes And Deferred Transaction Costs[Roll forward]              
Transactions Costs, beginning of period     $ 7,769        
Less: amortization     (4,153)       $ (617)
Conversions     (82,274)       0
Transactions Costs, end of period     3,617 $ 7,769      
Convertible Senior Notes Due 2019              
Convertible Notes And Deferred Transaction Costs[Roll forward]              
Notes Balance, beginning of period   $ 200,000 159,011 159,011 $ 177,787 $ 200,000 200,000
Transactions Costs, beginning of period   12,747 7,770 8,276 9,820 11,719 12,336
Notes, net of Transaction Costs, beginning of period   187,253 151,241 150,735 167,967 188,281 187,664
Less: amortization $ (3,600) (411) (4,153) (506) (1,544) (1,899) (617)
Conversions $ (79,800)   (79,829)   (18,776) (22,213)  
Notes Balance, end of period   200,000 79,182 159,011 159,011 177,787 200,000
Notes, net of Transaction Costs, end of period   187,664 75,565 151,241 150,735 167,967 188,281
Transactions Costs, end of period   $ 12,336 $ 3,617 $ 7,770 $ 8,276 $ 9,820 $ 11,719
v3.4.0.3
Accounting for Shared-Based Payments - Stock Options (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Jun. 08, 2015
Jun. 07, 2015
Shared-based payments        
Total stock-based compensation expense (income) $ 1,202 $ 2,405    
Research and development | Employee        
Shared-based payments        
Total stock-based compensation expense (income) 810 530    
General and administrative | Employee        
Shared-based payments        
Total stock-based compensation expense (income) $ 392 $ 1,875    
2008 Equity Compensation Incentive Plan        
Shared-based payments        
Number of shares reserved under the plan (in shares)     30,000,000 15,000,000
Stock Options        
Shared-based payments        
Vesting period 3 years      
Contractual term 10 years      
Unrecognized compensation cost related to non-vested employee stock options, net of expected forfeitures $ 16,300      
Weighted-average remaining vesting period over which unrecognized compensation cost is to be recognized 1 year 11 months 9 days      
Number of stock options which vest upon a change of control (in shares) 4,319,000      
Weighted-average assumptions used to estimate fair value of stock option awards using the Black-Scholes option valuation model        
Risk-free interest rate, minimum (as a percent) 1.47% 1.46%    
Risk-free interest rate, maximum (as a percent) 1.74% 2.02%    
Dividend yield (as percent) 0.00% 0.00%    
Expected volatility (as a percent) 60.00% 57.00%    
Expected term 6 years      
Minimum | Stock Options        
Weighted-average assumptions used to estimate fair value of stock option awards using the Black-Scholes option valuation model        
Expected term   6 years    
Maximum | Stock Options        
Weighted-average assumptions used to estimate fair value of stock option awards using the Black-Scholes option valuation model        
Expected term   9 years 3 months 18 days    
v3.4.0.3
Accounting for Shared-Based Payments - Schedule of Stock Option Activity (Details) - USD ($)
 3 Months Ended 7 Months Ended 12 Months Ended 87 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Jun. 22, 2010
Dec. 31, 2015
Mar. 31, 2016
Weighted Average Remaining Contractual Term          
Stock based compensation expense $ 1,202,000 $ 2,405,000      
Stock Options          
Number of Options          
Exercised (in shares) 0        
Weighted Average Exercise Price Per Share          
Exercised (in dollars per share) $ 0.00        
Stock Options | Contingent vesting          
Weighted Average Remaining Contractual Term          
Stock based compensation expense         $ 0
Stock Options | $0.44-9.12          
Number of Options          
Balance outstanding, beginning of period (in shares) 20,953,375        
Balance outstanding, end of period (in shares) 21,227,948     20,953,375 21,227,948
Exercisable at the end of the period (in shares) 9,991,733       9,991,733
Exercise Price Per Share          
Exercise price, low end of the range (in dollars per share) $ 0.44     $ 0.44  
Exercise price, high end of the range (in dollars per share) 9.12     9.12  
Weighted Average Exercise Price Per Share          
Balance outstanding, beginning of period (in dollars per share) 3.86        
Balance outstanding, end of period (in dollars per share) 3.83     $ 3.86 $ 3.83
Exercisable at the end of the period (in dollars per share) $ 3.30       $ 3.30
Intrinsic Value          
Intrinsic value of options outstanding $ 0     $ 42,438,000 $ 0
Intrinsic value of options exercisable, end of period $ 4,347,000       $ 4,347,000
Weighted Average Remaining Contractual Term          
Balance 7 years     7 years 1 month 24 days  
Exercisable at the end of the period 5 years 9 months 26 days        
Stock Options | $0.44-9.12 | Contingent vesting          
Number of Options          
Balance outstanding, end of period (in shares)     2,159,500    
Weighted Average Remaining Contractual Term          
Grant date fair value     $ 28,600,000    
Stock Options | $3.12-4.14          
Number of Options          
Granted (in shares) 405,000        
Exercise Price Per Share          
Exercise price, low end of the range (in dollars per share) $ 3.12        
Exercise price, high end of the range (in dollars per share) 4.14        
Weighted Average Exercise Price Per Share          
Granted (in dollars per share) $ 4.00        
Stock Options | $6-9.12          
Number of Options          
Forfeited (in shares) (130,427)        
Exercise Price Per Share          
Exercise price, low end of the range (in dollars per share) $ 6.00        
Exercise price, high end of the range (in dollars per share) 9.12        
Weighted Average Exercise Price Per Share          
Forfeited (in dollars per share) $ 6.65        
v3.4.0.3
Stockholders' Deficit (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
May. 06, 2016
Mar. 18, 2016
Mar. 31, 2016
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Nov. 03, 2014
Debt Instrument [Line Items]              
Debt conversion amount     $ 82,274     $ 0  
Common stock issued for interest on Notes     2,445     0  
Net proceeds from private placement     0     $ 5,558  
Convertible Senior Notes Due 2019              
Debt Instrument [Line Items]              
Debt conversion amount   $ 79,800 $ 79,829 $ 18,776 $ 22,213    
Percent of principal converted   50.00%          
Number of shares issued on conversion of debt (in shares)   35,300,000          
Number of shares issued on conversion price excluding share issued for accrued interest (in shares)   25,700,000          
Conversion price (in dollars per share)             $ 3.11
Number of shares issued for accrued interest (in shares)   872,000          
Five day average conversion price for accrued interest (in dollars per share)   $ 2.81          
Common stock issued for interest on Notes   $ 2,400          
Subsequent Event | Private Placement              
Debt Instrument [Line Items]              
Shares sold in private placement (in shares) 29,948,334            
Shares issued (in dollars per share) $ 3.00            
Net proceeds from private placement $ 89,700            
v3.4.0.3
Research and Development Expense (Details) - USD ($)
$ in Millions
Mar. 31, 2016
Dec. 31, 2015
Research and Development [Abstract]    
Prepaid research and development costs $ 2.8 $ 3.1
v3.4.0.3
Derivative Financial Instruments - Range of Assumptions (Details) - Derivative instrument liability - Warrants - Black-Scholes option pricing model - $ / shares
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Range of assumptions used to determine the fair value of the warrants    
Fair value of Synergy common stock (in dollars per share) $ 2.76 $ 4.62
Expected warrant term 1 year 10 months 24 days  
Risk-free interest rate (as a percent) 0.80%  
Expected volatility (as a percent) 60.00% 57.00%
Dividend yield (as a percent) 0.00% 0.00%
Minimum    
Range of assumptions used to determine the fair value of the warrants    
Expected warrant term   3 months
Risk-free interest rate (as a percent)   0.03%
Maximum    
Range of assumptions used to determine the fair value of the warrants    
Expected warrant term   2 years 10 months 24 days
Risk-free interest rate (as a percent)   0.89%
v3.4.0.3
Derivative Financial Instruments - Changes in Outstanding Warrants (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Changes in derivative instrument liability      
Balance at the beginning of the period $ 322    
Change in fair value of warrants during the quarter (260) $ 268  
Balance at the end of the period $ 62    
Derivative instrument liability      
Derivative Financial Instruments      
Balance of warrants outstanding 210,000   210,000
Changes in derivative instrument liability      
Balance at the beginning of the period $ 322    
Change in fair value of warrants during the quarter (260)    
Balance at the end of the period $ 62    
v3.4.0.3
Fair Value Measurements - Fair Value of Liabilities Measured on Recurring Basis (Details) - USD ($)
$ in Thousands
Mar. 31, 2016
Dec. 31, 2015
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Derivative financial instruments, at estimated fair value-warrants $ 62 $ 322
Derivative instrument liability    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Derivative financial instruments, at estimated fair value-warrants 62 322
Fair value on a recurring basis | Warrants | Derivative instrument liability    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Derivative financial instruments, at estimated fair value-warrants 62 322
Fair value on a recurring basis | Warrants | Derivative instrument liability | Level 3    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Derivative financial instruments, at estimated fair value-warrants $ 62 $ 322
v3.4.0.3
Fair Value Measurements - Level 3 Roll Forward (Details) - Warrants - Derivative instrument liability
$ in Thousands
 3 Months Ended
Mar. 31, 2016
USD ($)
Changes in the fair value of Level 3 liabilities  
Balance at the beginning of the period $ 322
(Gain) or loss recognized in earning from Change in Fair Value (260)
Expiration of Warrants 0
Balance at the end of the period $ 62
v3.4.0.3
Loss per Share (Details) - shares
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 51,415,221 86,880,818
Stock Options    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 21,227,948 16,621,065
Warrants    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 4,726,823 5,951,071
Senior Convertible Notes    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 25,460,450 64,308,682
v3.4.0.3
Subsequent Events (Details) - Private Placement - Subsequent Event
$ / shares in Units, $ in Millions
May. 06, 2016
USD ($)
$ / shares
shares
Subsequent Event [Line Items]  
Shares sold in private placement (in shares) | shares 29,948,334
Share price in private placement (in dollars per share) | $ / shares $ 3.00
Net proceeds from private placement | $ $ 89.7 
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