Form EFFECT OnKure Therapeutics,
| UNITED STATES | |
| SECURITIES AND EXCHANGE COMMISSION | |
| Washington, D.C. 20549 | |
| Notice of Effectiveness | |
| Effectiveness Date: | November 18, 2025 |
| Accession Number: | 0001193125-25-270150 | ||||||
| Submission Type: | POS AM | ||||||
| |||||||
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