Form EFFECT GUGGENHEIM DEFINED PORTF

April 23, 2026 6:05 AM EDT
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: April 22, 2026 1:00 P.M.
Form: S-6
CIK: 0002101830
Company Name: GUGGENHEIM DEFINED PORTFOLIOS, SERIES 2581
File Number: 333-293577


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