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Form 13F-HR RA CAPITAL MANAGEMENT, For: Mar 31

May 16, 2022 5:04 PM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: RA CAPITAL MANAGEMENT, L.P.
Address: 200 BERKELEY STREET, 18TH FLOOR
Boston , MA02116
Form 13F File Number: 028-12884

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Rajeev Shah
Title: Authorized Signatory
Phone: 617-778-2500
Signature, Place, and Date of Signing:
/s/ Rajeev Shah Boston , MA 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 96
Form 13F Information Table Value Total: 4,583,149
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 7,388 750,000 SH SOLE 750,000 0 0
89BIO INC COM 282559103 18,721 4,965,769 SH SOLE 4,965,769 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 14,743 5,014,687 SH SOLE 5,014,687 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 31,339 1,817,808 SH SOLE 1,817,808 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 38,204 9,770,773 SH SOLE 9,770,773 0 0
AEROVATE THERAPEUTICS INC COM 008064107 151,479 8,263,982 SH SOLE 8,263,982 0 0
AKOUOS INC COM 00973J101 10,836 2,281,249 SH SOLE 2,281,249 0 0
ALLOVIR INC COM 019818103 9,724 1,440,525 SH SOLE 1,440,525 0 0
AN2 THERAPEUTICS INC COM 037326105 55,257 3,666,663 SH SOLE 3,666,663 0 0
ARYA SCIENCES ACQUISITN CLASS A ORD SHS G31658100 9,710 1,000,000 SH SOLE 1,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 888,169 7,567,900 SH SOLE 7,567,900 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 8,469 1,262,193 SH SOLE 1,262,193 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 40,032 2,167,391 SH SOLE 2,167,391 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 12,338 1,250,000 SH SOLE 1,250,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 70,384 10,230,274 SH SOLE 10,230,274 0 0
BIOGEN INC COM 09062X103 153,111 727,024 SH SOLE 727,024 0 0
BIOMEA FUSION INC COM 09077A106 2,230 500,000 SH SOLE 500,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 7,174 2,589,904 SH SOLE 2,589,904 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 70,675 2,075,000 SH SOLE 2,075,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 32,087 3,577,094 SH SOLE 3,577,094 0 0
CENTURY THERAPEUTICS INC COM 15673T100 11,508 914,094 SH SOLE 914,094 0 0
CHEMOCENTRYX INC COM 16383L106 28,980 1,155,964 SH SOLE 1,155,964 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 16,360 1,000,000 SH SOLE 1,000,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 730 532,958 SH SOLE 532,958 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 10,223 3,033,603 SH SOLE 3,033,603 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 21,113 6,991,003 SH SOLE 6,991,003 0 0
CUE HEALTH INC COM 229790100 4,838 750,000 SH SOLE 750,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 3,665 350,000 SH SOLE 350,000 0 0
CVRX INC COM 126638105 1,647 275,000 SH SOLE 275,000 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 12,631 3,350,506 SH SOLE 3,350,506 0 0
CYTEK BIOSCIENCES INC COM 23285D109 144,248 13,381,054 SH SOLE 13,381,054 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 14,573 1,500,000 SH SOLE 1,500,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 60,116 6,060,090 SH SOLE 6,060,090 0 0
DESIGN THERAPEUTICS INC COM 25056L103 35,314 2,186,636 SH SOLE 2,186,636 0 0
DICE THERAPEUTICS INC COM 23345J104 99,646 5,208,911 SH SOLE 5,208,911 0 0
DYNE THERAPEUTICS INC COM 26818M108 27,041 2,805,045 SH SOLE 2,805,045 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 25,352 2,613,623 SH SOLE 2,613,623 0 0
ELIEM THERAPEUTICS INC COM 28658R106 110,336 13,150,849 SH SOLE 13,150,849 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 68,633 964,212 SH SOLE 964,212 0 0
ENTERA BIO LTD SHS M40527109 6,753 2,353,000 SH SOLE 2,353,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 40,952 3,370,506 SH SOLE 3,370,506 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 83,808 9,011,651 SH SOLE 9,011,651 0 0
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A121 9,990 1,000,000 SH SOLE 1,000,000 0 0
GERON CORP COM 374163103 40,972 30,126,299 SH SOLE 30,126,299 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 88,292 4,827,330 SH SOLE 4,827,330 0 0
GRAPHITE BIO INC COM 38870X104 13,762 2,698,369 SH SOLE 2,698,369 0 0
GUARDANT HEALTH INC COM 40131M109 31,555 476,380 SH SOLE 476,380 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 6,194 625,000 SH SOLE 625,000 0 0
ICOSAVAX INC COM 45114M109 41,983 5,963,565 SH SOLE 5,963,565 0 0
IMMUNOGEN INC COM 45253H101 103,489 21,741,458 SH SOLE 21,741,458 0 0
INSTIL BIO INC COM 45783C101 52,361 4,870,793 SH SOLE 4,870,793 0 0
IO BIOTECH INC COM 449778109 9,846 1,857,755 SH SOLE 1,857,755 0 0
ITEOS THERAPEUTICS INC COM 46565G104 142,147 4,417,259 SH SOLE 4,417,259 0 0
JANUX THERAPEUTICS INC COM 47103J105 124,337 8,670,644 SH SOLE 8,670,644 0 0
KALA PHARMACEUTICALS INC COM 483119103 15,007 10,874,613 SH SOLE 10,874,613 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 28,453 1,930,322 SH SOLE 1,930,322 0 0
KINNATE BIOPHARMA INC COM 49705R105 48,014 4,264,144 SH SOLE 4,264,144 0 0
LARIMAR THERAPEUTICS INC COM 517125100 5,192 1,281,860 SH SOLE 1,281,860 0 0
LIANBIO SPONSORED ADS 53000N108 28,400 7,655,015 SH SOLE 7,655,015 0 0
MACROGENICS INC COM 556099109 53,773 6,103,594 SH SOLE 6,103,594 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 14,423 2,246,503 SH SOLE 2,246,503 0 0
MIRATI THERAPEUTICS INC COM 60468T105 60,378 734,343 SH SOLE 734,343 0 0
MORPHIC HLDG INC COM 61775R105 11,197 278,874 SH SOLE 278,874 0 0
NATERA INC COM 632307104 53,303 1,310,289 SH SOLE 1,310,289 0 0
NKARTA INC COM 65487U108 63,786 5,605,129 SH SOLE 5,605,129 0 0
NOVAVAX INC COM NEW 670002401 51,024 692,794 SH SOLE 692,794 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 2,149 504,505 SH SOLE 504,505 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 6,903 9,694,789 SH SOLE 9,694,789 0 0
OTONOMY INC COM 68906L105 13,440 5,600,000 SH SOLE 5,600,000 0 0
PARDES BIOSCIENCES INC COM 69945Q105 44,584 6,175,038 SH SOLE 6,175,038 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 3,762 2,850,000 SH SOLE 2,850,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 35,608 1,710,265 SH SOLE 1,710,265 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 71,754 9,003,018 SH SOLE 9,003,018 0 0
PYXIS ONCOLOGY INC COM 747324101 9,220 2,282,173 SH SOLE 2,282,173 0 0
RELAY THERAPEUTICS INC COM 75943R102 16,433 549,055 SH SOLE 549,055 0 0
RELMADA THERAPEUTICS INC COM 75955J402 53,980 2,000,000 SH SOLE 2,000,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 56,115 4,871,067 SH SOLE 4,871,067 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 33,419 2,107,149 SH SOLE 2,107,149 0 0
RXSIGHT INC COM 78349D107 37,794 3,052,796 SH SOLE 3,052,796 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 22,474 5,914,252 SH SOLE 5,914,252 0 0
SCPHARMACEUTICALS INC COM 810648105 15,101 2,658,583 SH SOLE 2,658,583 0 0
SOLID BIOSCIENCES INC COM 83422E105 14,841 12,367,873 SH SOLE 12,367,873 0 0
SYNLOGIC INC COM 87166L100 16,000 6,666,666 SH SOLE 6,666,666 0 0
TANGO THERAPEUTICS INC COM 87583X109 17,055 2,250,000 SH SOLE 2,250,000 0 0
TENAYA THERAPEUTICS INC COM 87990A106 41,837 3,551,508 SH SOLE 3,551,508 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 126,864 4,922,941 SH SOLE 4,922,941 0 0
TSCAN THERAPEUTICS INC COM 89854M101 2,861 1,021,764 SH SOLE 1,021,764 0 0
TYRA BIOSCIENCES INC COM 90240B106 77,430 7,236,454 SH SOLE 7,236,454 0 0
VAXCYTE INC COM 92243G108 110,636 4,581,203 SH SOLE 4,581,203 0 0
VERA THERAPEUTICS INC CL A 92337R101 46,183 1,966,084 SH SOLE 1,966,084 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 25,449 5,100,000 SH SOLE 5,100,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 7,081 310,284 SH SOLE 310,284 0 0
VOR BIOPHARMA INC COM 929033108 67,171 11,120,973 SH SOLE 11,120,973 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 15,550 7,775,207 SH SOLE 7,775,207 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 18,884 4,291,881 SH SOLE 4,291,881 0 0
XILIO THERAPEUTICS INC COM 98422T100 14,156 2,002,217 SH SOLE 2,002,217 0 0


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