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Form 13F-HR ORBIMED ADVISORS LLC For: Mar 31

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May 17, 2021 4:23 PM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 03-31-2021
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: ORBIMED ADVISORS LLC
Address: 601 Lexington Avenue
54th Floor
New York , NY10022
Form 13F File Number: 028-06774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Sven H. Borho
Title: Member
Phone: 212-739-6400
Signature, Place, and Date of Signing:
/s/ Sven H. Borho New York , NY 05-17-2021
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 159
Form 13F Information Table Value Total: 10,694,926
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name
028-10410 ORBIMED CAPITAL LLC

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name
1 028-10410 ORBIMED CAPITAL LLC

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 88,313 3,729,442 SH SOLE 3,729,442 0 0
9 METERS BIOPHARMA INC COM 654405109 30,089 25,716,755 SH SOLE 25,716,755 0 0
ABBVIE INC COM 00287Y109 131,293 1,213,200 SH DFND 228,100 0 985,100
ABCELLERA BIOLOGICS INC COM 00288U106 278,498 8,200,768 SH SOLE 8,200,768 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 26,229 1,584,845 SH DFND 178,735 0 1,406,110
ACUTUS MED INC COM 005111109 73,240 5,477,958 SH SOLE 5,477,958 0 0
ADAGENE INC ADS 005329107 4,936 275,000 SH SOLE 275,000 0 0
ADICET BIO INC COM 007002108 94,606 7,232,856 SH SOLE 7,232,856 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 54,241 5,501,144 SH DFND 655,897 0 4,845,247
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 31,803 4,015,524 SH SOLE 4,015,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 6,700 5,193,946 SH SOLE 5,193,946 0 0
ALECTOR INC COM 014442107 12,315 611,478 SH SOLE 611,478 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 15,612 102,100 SH SOLE 0 0 102,100
ALEXION PHARMACEUTICALS INC COM 015351109 22,937 150,000 SH Call DFND 42,500 0 107,500
ALIGNMENT HEALTHCARE INC COM 01625V104 17,544 800,000 SH DFND 124,500 0 675,500
ALPINE IMMUNE SCIENCES INC COM 02083G100 32,552 3,070,955 SH SOLE 3,070,955 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 11,061 150,000 SH SOLE 0 0 150,000
AMGEN INC COM 031162100 22,766 91,500 SH SOLE 0 0 91,500
ANTHEM INC COM 036752103 102,875 286,600 SH DFND 39,800 0 246,800
APPLIED THERAPEUTICS INC COM 03828A101 42,337 2,257,387 SH DFND 156,706 0 2,100,681
APTOSE BIOSCIENCES INC COM NEW 03835T200 47,979 8,030,000 SH SOLE 0 0 8,030,000
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 49,844 1,206,886 SH DFND 159,626 0 1,047,260
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 175,716 6,073,850 SH DFND 4,267,564 0 1,806,286
ARYA SCIENCES ACQUISITION CO COM CL A G3166W106 680 49,375 SH DFND 20,900 0 28,475
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 65,105 505,159 SH DFND 61,000 0 444,159
ASLAN PHARMACEUTICALS LTD ADS 04522R101 8,442 2,520,000 SH SOLE 0 0 2,520,000
AURINIA PHARMACEUTICALS INC COM 05156V102 78,806 6,069,032 SH DFND 585,300 0 5,483,732
AXSOME THERAPEUTICS INC COM 05464T104 2,831 50,000 SH Put DFND 18,000 0 32,000
BELLUS HEALTH INC NEW COM NEW 07987C204 15,100 3,954,800 SH SOLE 3,954,800 0 0
BIOGEN INC COM 09062X103 22,940 82,000 SH SOLE 0 0 82,000
BIOMX INC COM 09090D103 16,472 2,313,489 SH SOLE 2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 267,481 6,920,600 SH DFND 939,400 0 5,981,200
BRISTOL-MYERS SQUIBB CO COM 110122108 285,057 4,515,400 SH DFND 569,100 0 3,946,300
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 51,085 1,897,663 SH DFND 201,999 0 1,695,664
CATALYST BIOSCIENCES INC COM NEW 14888D208 10,678 2,118,600 SH SOLE 0 0 2,118,600
CEL-SCI CORP COM PAR NEW 150837607 1,521 100,000 SH Put DFND 35,500 0 64,500
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 74,019 2,578,174 SH SOLE 2,578,174 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 19,425 1,250,001 SH DFND 250,000 0 1,000,001
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 4,706 127,816 SH DFND 38,816 0 89,000
CORVUS PHARMACEUTICALS INC COM 221015100 24,804 8,053,298 SH SOLE 8,053,298 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 42,075 2,753,567 SH SOLE 2,753,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 67,322 552,500 SH DFND 47,500 0 505,000
CTI BIOPHARMA CORP COM 12648L601 21,885 7,520,600 SH SOLE 7,520,600 0 0
CULLINAN ONCOLOGY INC COM 230031106 47,760 1,146,145 SH DFND 959,245 0 186,900
CURIS INC COM NEW 231269200 49,429 4,366,494 SH DFND 195,900 0 4,170,594
DECIBEL THERAPEUTICS INC COM 24343R106 56,177 4,945,192 SH DFND 4,061,774 0 883,418
DECIPHERA PHARMACEUTICALS IN COM 24344T101 61,920 1,380,900 SH DFND 190,100 0 1,190,800
DEXCOM INC COM 252131107 106,883 297,400 SH DFND 37,000 0 260,400
DYNE THERAPEUTICS INC COM 26818M108 5,436 350,000 SH SOLE 0 0 350,000
EDGEWISE THERAPEUTICS INC COM 28036F105 453,202 13,944,680 SH DFND 13,679,055 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108 94,212 1,126,400 SH DFND 151,600 0 974,800
FLEXION THERAPEUTICS INC COM 33938J106 20,657 2,308,083 SH DFND 84,100 0 2,223,983
FLUIDIGM CORP DEL COM 34385P108 2,260 500,000 SH Call DFND 175,500 0 324,500
FLUIDIGM CORP DEL COM 34385P108 20,790 4,599,571 SH DFND 484,800 0 4,114,771
FORTE BIOSCIENCES INC COM 34962G109 5,472 159,664 SH DFND 55,530 0 104,134
FUSION PHARMACEUTICALS INC COM 36118A100 34,570 3,224,770 SH DFND 2,930,670 0 294,100
GALAPAGOS NV SPON ADR 36315X101 17,800 230,905 SH DFND 25,700 0 205,205
GALECTO INC COM 36322Q107 24,852 4,090,937 SH DFND 3,803,255 0 287,682
GEMINI THERAPEUTICS INC COM 36870G105 78,945 5,826,224 SH SOLE 5,826,224 0 0
GILEAD SCIENCES INC COM 375558103 18,588 287,600 SH SOLE 0 0 287,600
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 121,427 7,884,870 SH DFND 5,970,672 0 1,914,198
GRAYBUG VISION INC COM SHS 38942Q103 23,107 4,163,347 SH SOLE 4,163,347 0 0
GUARDANT HEALTH INC COM 40131M109 149,200 977,400 SH DFND 108,700 0 868,700
HAEMONETICS CORP MASS COM 405024100 94,581 852,000 SH DFND 90,500 0 761,500
HARPOON THERAPEUTICS INC COM 41358P106 47,817 2,285,704 SH DFND 1,020,704 0 1,265,000
HEALTH CATALYST INC COM 42225T107 8,400 179,598 SH SOLE 179,598 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,595 500,000 SH DFND 100,000 0 400,000
HORIZON THERAPEUTICS PUB L SHS G46188101 289,406 3,144,355 SH DFND 357,500 0 2,786,855
HUMANA INC COM 444859102 131,477 313,600 SH DFND 48,100 0 265,500
I MAB SPONSORED ADS 44975P103 900 18,565 SH DFND 1,900 0 16,665
IKENA ONCOLOGY INC COM 45175G108 82,884 2,933,941 SH DFND 1,936,886 0 997,055
IKENA ONCOLOGY INC NONVOTING 000000000 175,587 6,215,466 SH DFND 5,586,311 0 629,155
IMARA INC COM 45249V107 22,956 2,719,902 SH DFND 2,532,402 0 187,500
IMMUNOGEN INC COM 45253H101 73,968 9,131,822 SH DFND 573,800 0 8,558,022
INFLARX NV COM N44821101 4,150 1,064,118 SH SOLE 0 0 1,064,118
INNOVAGE HLDG CORP COM 45784A104 5,158 200,000 SH SOLE 0 0 200,000
INTELLIA THERAPEUTICS INC COM 45826J105 5,818 72,500 SH SOLE 0 0 72,500
INTUITIVE SURGICAL INC COM NEW 46120E602 103,156 139,600 SH DFND 20,800 0 118,800
IOVANCE BIOTHERAPEUTICS INC COM 462260100 210,384 6,645,100 SH DFND 1,337,800 0 5,307,300
JOUNCE THERAPEUTICS INC COM 481116101 18,728 1,823,600 SH DFND 335,900 0 1,487,700
KALA PHARMACEUTICALS INC COM 483119103 36,834 5,465,030 SH DFND 4,714,195 0 750,835
KEROS THERAPEUTICS INC COM 492327101 103,368 1,679,417 SH DFND 1,268,734 0 410,683
KINNATE BIOPHARMA INC COM 49705R105 119,901 3,847,929 SH DFND 3,397,929 0 450,000
LANDOS BIOPHARMA INC COM 515069102 6,558 681,000 SH SOLE 0 0 681,000
LARIMAR THERAPEUTICS INC COM 517125100 9,018 617,245 SH DFND 107,384 0 509,861
LOGICBIO THERAPEUTICS INC COM 54142F102 61,638 8,466,783 SH DFND 7,948,265 0 518,518
LONGBOARD PHARMACEUTICALS IN COM 54300N103 4,914 300,000 SH SOLE 0 0 300,000
MAGENTA THERAPEUTICS INC COM 55910K108 11,237 949,048 SH SOLE 0 0 949,048
MEIRAGTX HLDGS PLC COM G59665102 59,205 4,102,925 SH DFND 133,500 0 3,969,425
MERCK & CO. INC COM 58933Y105 287,731 3,732,400 SH DFND 465,000 0 3,267,400
MEREO BIOPHARMA GROUP PLC ADS 589492107 58,183 17,264,763 PRN DFND 9,210,992 0 8,053,771
MERSANA THERAPEUTICS INC COM 59045L106 30,621 1,892,500 SH DFND 77,900 0 1,814,600
MILESTONE PHARMACEUTICALS IN COM 59935V107 14,960 2,583,821 SH SOLE 0 0 2,583,821
MIRATI THERAPEUTICS INC COM 60468T105 209,192 1,221,200 SH DFND 170,900 0 1,050,300
MOLINA HEALTHCARE INC COM 60855R100 37,963 162,400 SH DFND 20,600 0 141,800
NANOBIOTIX SA SPONSORED ADS 63009J107 7,520 500,000 SH SOLE 0 0 500,000
NANOSTRING TECHNOLOGIES INC COM 63009R109 40,931 622,900 SH DFND 62,900 0 560,000
NATERA INC COM 632307104 222,972 2,195,900 SH DFND 273,300 0 1,922,600
NEUROCRINE BIOSCIENCES INC COM 64125C109 126,592 1,301,715 SH DFND 137,470 0 1,164,245
NEXTCURE INC COM 65343E108 27,137 2,711,013 SH SOLE 2,711,013 0 0
NOVAVAX INC COM NEW 670002401 28,254 155,833 SH DFND 20,210 0 135,623
NURIX THERAPEUTICS INC COM 67080M103 9,327 300,000 SH SOLE 0 0 300,000
NUVATION BIO INC COM CL A 67080N101 8,360 800,000 SH SOLE 0 0 800,000
OAK STR HEALTH INC COM 67181A107 52,479 967,000 SH DFND 108,000 0 859,000
OLEMA PHARMACEUTICALS INC COM 68062P106 21,770 656,126 SH DFND 227,792 0 428,334
OLINK HLDG AB SPONSORED ADS 680710100 10,800 300,000 SH SOLE 0 0 300,000
ONCOCYTE CORP COM 68235C107 10,899 2,100,000 SH SOLE 0 0 2,100,000
ORIC PHARMACEUTICALS INC COM 68622P109 57,271 2,337,574 SH DFND 2,212,571 0 125,003
OTONOMY INC COM 68906L105 8,288 3,250,000 SH DFND 769,200 0 2,480,800
PANDION THERAPEUTICS INC COM 698340106 31,720 528,229 SH SOLE 528,229 0 0
PASSAGE BIO INC COM 702712100 121,711 6,962,899 SH DFND 5,947,323 0 1,015,576
PMV PHARMACEUTICALS INC COM 69353Y103 241,098 7,330,423 SH DFND 6,589,330 0 741,093
PRELUDE THERAPEUTICS INC COM 74065P101 435,020 10,039,691 SH DFND 9,250,191 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000 246,122 5,680,186 SH DFND 5,596,886 0 83,300
PROGYNY INC COM 74340E103 85,693 1,925,260 SH DFND 200,900 0 1,724,360
PROMETHEUS BIOSCIENCES INC COM 74349U108 4,565 250,000 SH SOLE 0 0 250,000
PROTARA THERAPEUTICS INC COM STK 74365U107 7,083 450,000 SH DFND 60,000 0 390,000
PULMONX CORP COM 745848101 5,718 125,000 SH SOLE 0 0 125,000
PURPLE BIOTECH LTD SPONSORED ADS 74638P109 130 31,418 SH SOLE 31,418 0 0
RELAY THERAPEUTICS INC COM 75943R102 12,100 350,000 SH SOLE 0 0 350,000
REPARE THERAPEUTICS INC COM 760273102 105,154 3,426,325 SH DFND 3,276,325 0 150,000
SANA BIOTECHNOLOGY INC COM 799566104 2,008 60,000 SH SOLE 0 0 60,000
SAREPTA THERAPEUTICS INC COM 803607100 14,927 200,278 SH DFND 64,700 0 135,578
SCPHARMACEUTICALS INC COM 810648105 31,901 4,797,148 SH SOLE 4,797,148 0 0
SELECTA BIOSCIENCES INC COM 816212104 1,535 339,169 SH SOLE 339,169 0 0
SI BONE INC COM 825704109 41,522 1,305,300 SH SOLE 0 0 1,305,300
SIERRA ONCOLOGY INC COM NEW 82640U404 25,454 1,477,320 SH DFND 1,306,860 0 170,460
SIGNIFY HEALTH INC CL A COM 82671G100 6,584 225,000 SH SOLE 0 0 225,000
SILVER SPIKE ACQUISITION COR *W EXP 08/02/202 G8136L114 1,057 150,200 SH SOLE 0 0 150,200
SILVER SPIKE ACQUISITION COR CL A SHS G8136L106 12,859 700,400 SH SOLE 0 0 700,400
SILVERBACK THERAPEUTICS INC COM 82835W108 381,365 8,740,887 SH DFND 7,788,510 0 952,377
SINOVAC BIOTECH LTD SHS P8696W104 72,000 2,839,500 SH SOLE 0 0 2,839,500
SPRINGWORKS THERAPEUTICS INC COM 85205L107 455,127 6,186,307 SH SOLE 6,186,307 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 4,815 1,744,669 SH DFND 251,200 0 1,493,469
STRYKER CORPORATION COM 863667101 82,184 337,400 SH DFND 53,200 0 284,200
SUTRO BIOPHARMA INC COM 869367102 7,966 350,000 SH SOLE 0 0 350,000
SYNLOGIC INC COM 87166L100 7,267 2,029,996 SH SOLE 2,029,996 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 13,745 1,837,500 SH SOLE 0 0 1,837,500
TCR2 THERAPEUTICS INC COM 87808K106 5,504 249,279 SH SOLE 0 0 249,279
TELA BIO INC COM 872381108 45,110 3,027,542 SH SOLE 3,027,542 0 0
TERNS PHARMACEUTICALS INC COM 880881107 83,406 3,791,204 SH SOLE 3,791,204 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 126,932 6,219,110 SH DFND 674,898 0 5,544,212
THERMO FISHER SCIENTIFIC INC COM 883556102 50,339 110,300 SH DFND 16,800 0 93,500
TRAVERE THERAPEUTICS INC COM 89422G107 13,187 528,100 SH DFND 64,700 0 463,400
TRICIDA INC COM 89610F101 50,860 9,614,280 SH SOLE 9,614,280 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 18 1,700 SH Call DFND 700 0 1,000
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 33,994 3,165,200 SH DFND 206,900 0 2,958,300
TURNING POINT THERAPEUTICS I COM 90041T108 223,358 2,361,327 SH DFND 1,743,950 0 617,377
UNIQURE NV SHS N90064101 32,648 969,079 SH DFND 138,100 0 830,979
UNITEDHEALTH GROUP INC COM 91324P102 149,944 403,000 SH DFND 56,500 0 346,500
VAXCYTE INC COM 92243G108 12,813 648,774 SH SOLE 0 0 648,774
VERONA PHARMA PLC SPONSORED ADS 925050106 47,609 5,694,841 SH DFND 5,028,174 0 666,667
VERRICA PHARMACEUTICALS INC COM 92511W108 22,418 1,479,733 SH SOLE 1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 244,094 1,135,900 SH DFND 136,200 0 999,700
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 18,327 8,604,000 SH DFND 979,000 0 7,625,000
VOR BIOPHARMA INC COM 929033108 35,917 833,333 SH SOLE 0 0 833,333
X4 PHARMACEUTICALS INC COM 98420X103 11,829 1,373,849 SH SOLE 1,373,849 0 0
XENON PHARMACEUTICALS INC COM 98420N105 44,713 2,497,917 SH DFND 786,612 0 1,711,305
XTANT MED HLDGS INC COM NEW 98420P308 171,981 72,873,494 SH SOLE 72,873,494 0 0

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