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Form 13F-HR Novo Holdings A/S For: Mar 31

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May 16, 2022 7:17 AM EDT

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Novo Holdings A/S
Address: TUBORG HAVNEVEJ 19
HELLERUP , G72900
Form 13F File Number: 028-16231

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Barbara Fiorini Due
Title: General Counsel
Phone: 45 3527 6500
Signature, Place, and Date of Signing:
/s/ Barbara Fiorini Due Hellerup , G7 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 53
Form 13F Information Table Value Total: 2,354,941
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AKOUOS INC COM 00973J101 5,044 1,061,990 SH SOLE 1,061,990 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 54,490 500,827 SH SOLE 500,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 4,193 1,950,000 SH SOLE 1,950,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,082 25,000 SH SOLE 25,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 24,245 2,560,211 SH SOLE 2,560,211 0 0
ARCELLX, INC. COMMON STOCK 03940C100 56,317 4,016,878 SH SOLE 4,016,878 0 0
APPLE INC COM 037833100 106,666 610,879 SH SOLE 610,879 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 143,671 215,099 SH SOLE 215,099 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 14,534 227,526 SH SOLE 227,526 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 12,341 4,503,991 SH SOLE 4,503,991 0 0
BOSTON SCIENTIFIC CORP COM 101137107 153,402 3,463,577 SH SOLE 3,463,577 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 165,251 2,921,171 SH SOLE 2,921,171 0 0
CABLE ONE INC COM 12685J105 23,242 15,873 SH SOLE 15,873 0 0
CATALENT INC COM 148806102 141,032 1,271,707 SH SOLE 1,271,707 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 6,897 2,161,990 SH SOLE 2,161,990 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 9,326 424,897 SH SOLE 424,897 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 18,248 4,840,413 SH SOLE 4,840,413 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 54,196 5,587,207 SH SOLE 5,587,207 0 0
EVOTEC AG SPONSORED ADS 30050E105 270,748 17,894,807 SH SOLE 17,894,807 0 0
EXSCIENTIA PLC ADS 30223G102 188,447 13,086,600 SH SOLE 13,086,600 0 0
GALECTO INC COM 36322Q107 5,495 2,497,791 SH SOLE 2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 5,852 2,459,021 SH SOLE 2,459,021 0 0
INARI MED INC COM 45332Y109 11,160 123,122 SH SOLE 123,122 0 0
INOGEN INC COM 45780L104 34,778 1,072,735 SH SOLE 1,072,735 0 0
INSMED INC COM PAR $.01 457669307 16,587 705,838 SH SOLE 705,838 0 0
INSPIRE MED SYS INC COM 457730109 10,639 41,448 SH SOLE 41,448 0 0
IO BIOTECH INC COM 449778109 17,373 3,277,932 SH SOLE 3,277,932 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 13,928 836,518 SH SOLE 836,518 0 0
KINNATE BIOPHARMA INC COM 49705R105 7,029 624,236 SH SOLE 624,236 0 0
LAVA THERAPEUTICS NV SHS N51517105 14,640 3,327,312 SH SOLE 3,327,312 0 0
MARQETA INC CLASS A COM 57142B104 4,875 441,558 SH SOLE 441,558 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,243 2,530,003 SH SOLE 2,530,003 0 0
MINERVA SURGICAL INC COM 60343F106 9,220 2,048,892 SH SOLE 2,048,892 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 48,444 2,200,000 SH SOLE 2,200,000 0 0
MORPHIC HLDG INC COM 61775R105 65,638 1,634,811 SH SOLE 1,634,811 0 0
NKARTA INC COM 65487U108 31,794 2,793,863 SH SOLE 2,793,863 0 0
PHARVARIS N V COM N69605108 9,366 516,321 SH SOLE 516,321 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 2,553 250,000 SH SOLE 250,000 0 0
PULMONX CORP COM 745848101 10,176 410,155 SH SOLE 410,155 0 0
RALLYBIO CORP COM 75120L100 3,043 435,944 SH SOLE 435,944 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 10,085 3,430,377 SH SOLE 3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 9,719 612,822 SH SOLE 612,822 0 0
SALESFORCE.COM, INC. COM 79466L302 63,484 299,000 SH SOLE 299,000 0 0
SEASPINE HLDGS CORP COM 81255T108 10,442 858,752 SH SOLE 858,752 0 0
SILK RD MED INC COM 82710M100 11,399 276,068 SH SOLE 276,068 0 0
SPERO THERAPEUTICS INC COM 84833T103 4,079 468,902 SH SOLE 468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 9,074 4,514,336 SH SOLE 4,514,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 47,832 458,780 SH SOLE 458,780 0 0
TREACE MED CONCEPTS INC COM 89455T109 9,463 500,421 SH SOLE 500,421 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 347,322 1,525,550 SH SOLE 1,525,550 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 15,922 3,380,402 SH SOLE 3,380,402 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,798 761,205 SH SOLE 761,205 0 0
VERVE THERAPEUTICS INC COM 92539P101 17,115 750,000 SH SOLE 750,000 0 0

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