Global Kratom Coalition Endorses New Safety and Tolerability Study

Researchers report no serious adverse events or deaths from daily doses of dried kratom leaf powder

WASHINGTON, DC, January 08, 2026 (EZ Newswire) -- The Global Kratom Coalition (GKC) today endorsed the findings of a new clinical study published in Therapeutic Drug Monitoring, which showed that natural kratom leaf powder was safe and well tolerated at the serving sizes tested, with no evidence of meaningful abuse potential or withdrawal.

In this large, controlled natural kratom-administration study — the 18th kratom leaf human clinical trial to date — researchers evaluated the safety and tolerability of four escalating single and 15 daily dried kratom leaf powder servings in human volunteers over 47 days, reporting no serious adverse events, no withdrawal, and no meaningful abuse potential. 

“The study’s findings underscore natural kratom leaf’s established safety profile, reinforced by centuries of safe use in communities from Southeast Asia to here in the United States,” said Matthew Lowe, GKC’s executive director. “With scant evidence of abuse liability and a low acute overdose risk, the science shows that natural kratom leaf remains safe and well tolerated when consumed responsibly.”

The new study follows several previous clinical trials and statements by public health officials affirming the safety and tolerability of natural kratom leaf — and clarifying that reported natural kratom leaf fatalities are rare and overwhelmingly involve polysubstance use, not natural kratom leaf alone.

As an example, the recent Food and Drug Administration (FDA) single-ascending-dose study of natural kratom leaf — testing amounts up to 12 grams, four times greater than the amount used by typical consumers — found no concerning adverse effects and strong tolerability.  

To learn more about the Global Kratom Coalition and its mission, navigate to globalkratomcoalition.org.

About Global Kratom Coalition

The Global Kratom Coalition is an alliance of natural kratom consumers, experts, and industry leaders dedicated to protecting access to natural leaf kratom while advancing scientific research, driving consumer education, and developing robust regulations to protect consumers. For more information, visit globalkratomcoalition.org.

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