Studies Highlight Impacts of Applying New Technologies in Everyday Care
- S&P, Dow eke out another record closing high as Nvidia momentum endures
- Goldman Sachs no longer expects Fed rate cut in May - reports
- Stocks eke out gain as Nvidia rally slows, yields slip
- Oil ends lower, posts weekly decline as US rate cut hopes dim
- Dollar index on track for first weekly fall this year
Findings show benefits of AI-driven techniques, chemotherapy-free treatments, and cell therapy
"These studies together illustrate the power new technologies and innovations hold for better meeting medical needs," said
The first two studies apply artificial intelligence (AI) techniques to aid clinicians in accurately diagnosing blood cancers and understanding the experiences of patients with sickle cell disease (SCD), respectively.
The third study reports excellent outcomes from the use of a fully oral regimen as a frontline therapy for treating acute promyelocytic leukemia, results that
The fourth study offers promising findings from a study applying CD19-targeting chimeric antigen receptor (CAR) T-cell therapy to serious autoimmune diseases. Although the study is relatively small and the results are preliminary, the results suggest autoimmune disease could become a new frontier in extending cell therapy beyond hematologic malignancies.
AI shows promise as support tool for identifying rare blood cancers
901: Interpretable Artificial Intelligence (AI) Differentiates Prefibrotic Primary Myelofibrosis (prePMF) from Essential Thrombocythemia (ET): A Multi-Center Study of a New Clinical Decision Support Tool
Distinguishing and identifying prefibrotic primary myelofibrosis (prePMF) from essential thrombocythemia (ET) is important to inform treatment approaches and enroll patients in clinical trials, but this is difficult to do with current diagnostic methods. A new study suggests AI algorithms could help.
Myeloproliferative neoplasms (MPNs) are a type of cancer in which the bone marrow overproduces certain types of blood cell. PrePMF is rarer and has a much worse prognosis than ET, with a median survival of 12 years compared with 22 years for ET. As a result, prePMF eventually may require more aggressive treatment; however, getting a definitive diagnosis is difficult and experts do not always agree when interpreting laboratory and biopsy results.
The study, which involved a model previously trained on over 32,000 pan-cancer biopsy images that has learned general pathological features, is the largest test to use AI to differentiate between prePMF and ET. The AI-based system used patient images from the
"With the combined accuracy, sensitivity, and specificity we saw, it would allow the physician to be confident in one diagnosis versus another and help rule in or rule out the rarer prePMF diagnosis, particularly for clinical trials," said Andrew Srisuwananukorn, MD, assistant professor at The Ohio State University Comprehensive Cancer Center, the study's lead author, who completed this work during his fellowship at Icahn School of Medicine at Mount Sinai. "My hope is that it would maintain this accuracy when tested in larger cohorts."
To aid diagnosis, the researchers trained an AI algorithm to distinguish features indicating prePMF versus ET in bone marrow biopsy images from 200 patients in
The AI system performed well, showing 92.3% agreement with human experts. The sensitivity and specificity for prePMF diagnosis was 66.6% and 100%, respectively. After further testing, Dr. Srisuwananukorn said the algorithm could potentially be used as a companion tool for clinical diagnoses and help doctors match patients with the clinical trials that are most likely to help them, which could ultimately result in better treatments.
Researchers cautioned that the algorithm is intended to complement, not replace, human experts. "What we're trying to develop is a clinical decision support tool, with an emphasis on support," said Dr. Srisuwananukorn. "Physicians with no computer science background are increasingly recognizing the value of AI algorithms and closer to being able to use them for their clinical practice. However, more investigations would be needed for this algorithm to be used in clinical practice, including testing in cohorts with different racial backgrounds."
The researchers plan to continue to refine the system and test it with larger data sets. In addition, Dr. Srisuwananukorn said AI could potentially be used to advance basic research on MPNs to link biological processes with particular morphological features visible on biopsy slides. Eventually, this could lead to ways to predict a person's prognosis or response to treatment based on biopsy images, he added.
Andrew Srisuwananukorn, MD, The Ohio State University Comprehensive Cancer Center, will present this study during an oral presentation on
Social media posts underscore burden of living with sickle cell disease
1057: Understanding the experiences of patients with sickle cell disease and their caregivers by social media listening in the
An analysis of social media posts reveals striking evidence that people living with SCD in the
"If you were to ask patients about their sickle cell disease care in the clinic, it is likely you would get a filtered response. Interestingly, people are far more open to sharing their experiences on social media, so I think this approach provides quite a candid view of the patient experience," said
He added that, "These first-hand accounts illustrate the burden of the disease on patients and caregivers, including limited access to emergency care, racial bias, and negative preconceptions when seeking medical care, and reinforce the need to further increase education within the medical community to help improve patient care."
In addition to long-term organ damage, SCD causes episodes of acute pain called vaso-occlusive crises that often require strong painkillers, such as opioids. Patient anecdotes and previous studies indicate that some patients have experienced treatment delays because health care professionals do not have an appropriate understanding of SCD and incorrectly perceive patients as drug seekers.
For the study, researchers partnered with data analysts and a patient living with SCD to develop a list of search terms to find public posts related to SCD on social media platforms including Instagram, TikTok, X (formerly known as Twitter), and online forums. Researchers used analytics to visualize the data at scale and used AI to identify high level themes. Using a random sample of the posts, they isolated posts specifically related to patient and caregiver interactions and applied a natural language processing algorithm to detect key topics of discussion, which researchers then manually validated and contextualized.
In total, the study captured over 45,000 posts from users in the
Within each theme, a significantly greater proportion of posts were determined to be negative than positive, although over half of posts overall were considered neutral. Many posters expressed a desire for a higher number of effective SCD treatments in the
In addition to sharing the results with the scientific community, the researchers plan to develop layperson summaries of the findings to increase awareness of SCD and its impacts on families, employers, and the general public. They also are planning to develop targeted educational programs to improve awareness among front-line health care professionals who may be less familiar with this rare disease.
Researchers noted that the analysis method could be useful for better understanding the experiences of people with other types of diseases, as well.
"This approach lends itself particularly well to rare diseases," said
The study was limited to posts shared via IP addresses in the
Oral regimen with minimal chemotherapy found safe and effective for treating APL
157: An Entirely Oral Regimen of Oral-Arsenic Trioxide/All-Trans Retinoic Acid/Ascorbic Acid in Newly-Diagnosed Acute Promyelocytic Leukaemia (APL): Updated Results of an Ongoing Multicentre Trial
Patients with acute promyelocytic leukemia (APL) who received a combination therapy including arsenic trioxide, all-trans retinoic acid, and ascorbic acid (AAA) in oral form with no or minimal chemotherapy showed high rates of survival and relapse-free survival at three years, according to new findings from a multicenter trial in
The study is the first to evaluate survival outcomes from an entirely oral AAA regimen in patients with both high- and standard-risk forms of APL, a form of blood cancer in which certain forms of immature white blood cells (abnormal promyelocytes) harboring the PML::RARA fusion oncogene accumulate in the bone marrow. People with APL have a high fatality rate due to bleeding complications if untreated.
The latest study findings suggest APL can be effectively treated with this synergistic oral regimen in most cases without the need to administer any of the drugs intravenously or accompany the treatment with chemotherapy, according to researchers.
"This entirely oral regimen is highly effective, safe, and can be administered in an outpatient setting for all risk categories," said
Historically, standard of care for both newly diagnosed and relapsed APL has included intravenous administration of arsenic trioxide and chemotherapy, which requires repeated hospital admissions and causes treatment-related toxicities. However, recent studies have suggested that an oral formulation of arsenic trioxide can perform just as well, and eliminating or minimizing chemotherapy can reduce hospitalizations (and associated costs) as well as side effects and long-term complications.
For the study, researchers administered an entirely oral AAA regimen to 117 patients (including five children) with newly diagnosed APL at sites in
Participants showed deep molecular responses to treatment, with all patients achieving a complete response initially. After a median follow-up time of 32 months, the rates of three-year overall and relapse-free survival were 99% and 97%, respectively.
Eight patients who were initially enrolled in the study died before receiving the full drug regimen, most from bleeding in the brain as a result of their APL. One patient died during the course of the study, which was determined to be unrelated to the treatment, and one patient experienced a disease relapse, which was determined to be related to a rare genetic mutation conferring resistance to arsenic trioxide, according to
No cardiotoxicity or serious adverse events were reported, and the most common adverse events were low-grade headache and elevation of liver enzymes. APL differentiation syndrome, a known complication of treatment with all-trans retinoic acid and arsenic trioxide, occurred in over half of patients, which was resolved in all cases with the standard treatment of intravenous steroids.
Taken together, researchers say the results extend and enhance previously reported evidence on the safety and efficacy of an all-oral treatment regimen for APL.
"This brings us from a practice that involves repeated hospital admissions to an outpatient-based practice that doesn't require a lot of intensive monitoring," said
Additional studies are being planned to further assess the use of intravenous and oral formulations of arsenic trioxide as frontline treatment for APL.
This study was supported by the Innovation and Technology Fund, Innovation and Technology Commission, the Government of the Hong Kong SAR (project code: PRP/029/22FX).
CAR T-Cell therapy results in rapid and marked improvement in autoimmune diseases
220: CD19-Targeted CAR-T Cells in Refractory Systemic Autoimmune Diseases: A Monocentric Experience from the First Fifteen Patients
Fifteen patients with severe autoimmune diseases who received CD19-targeting chimeric antigen receptor (CAR) T cells experienced substantial improvements and no longer required any other treatments for their autoimmune disease, according to a new study. The preliminary findings include a median of 15 months of follow-up.
The research is the first to test CAR T-cell therapy in autoimmune diseases, according to
"CD19 CAR T cells are well tolerated in B-cell driven autoimmune diseases, and the disease is entirely controlled without any additional disease-related therapeutics so far," said
For CAR T-cell therapy, a patient's white blood cells are removed from the body and the T cells are separated out, genetically altered, and allowed to multiply. The altered T cells, known as CAR T-cells, are infused back into the body and attack disease-causing cells. CAR-T therapy is a well-established treatment for certain types of blood cancer. Researchers are now exploring whether it can also fight other diseases.
Autoimmune diseases occur when a person's immune system erroneously attacks their own cells. Based on laboratory studies and preliminary clinical results, it appears that CD19-targeting CAR T cells can effectively seek and destroy errant B cells that cause some types of autoimmune diseases and restore proper immune cell functioning.
For the study, the researchers enrolled eight patients with SLE, four with SSc, and three with IIM who faced serious or life-threatening disease that was not or no longer responding to multiple standard treatments. Before receiving the CAR-T therapy, all of the patients faced an extremely poor prognosis, and several were so weak that they could not walk farther than a few meters.
After receiving their CAR-T infusions, B cells were eliminated from the blood within a week and then reoccurred in most patients a few months later. At the time of reporting, patients have been followed for a median of 15 months after their CAR-T infusion (with a range of four to 29 months) and all patients are doing well, show decreased disease activity, and have stopped taking immunosuppressive drugs.
The therapy was well tolerated overall. Ten patients experienced mild cytokine-release syndrome – an inflammatory side effect of CAR-T therapy – one experienced moderate cytokine-release syndrome, and one experienced vertigo. No serious treatment-related adverse events were reported.
Based on the findings, researchers say CAR-T therapy appears to be a promising alternative to autologous stem cell transplant, which is currently seen as the most curative option for life-threatening autoimmune disease when other treatments do not work, but which carries a significant risk of serious side effects.
"We have opened up an entirely new route of possibly treating several more diseases," said
Researchers said it will take several years, along with a larger group of patients, to determine whether the therapy confers longer-term benefits in the context of chronic autoimmune diseases. They added that it is still too early to tell whether it works equally well for SLE, SSc, and IIM, or if particular diseases see a better response. Additional clinical trials are underway to test CAR T-cell therapy in these and several other autoimmune disorders.
The American Society of Hematology (ASH) (hematology.org) is the world's largest professional society of hematologists dedicated to furthering the understanding, diagnosis, treatment, and prevention of disorders affecting the blood. For more than 60 years, the Society has led the development of hematology as a discipline by promoting research, patient care, education, training, and advocacy in hematology.
ASH's flagship journal, Blood (bloodjournal.org) is the most cited peer-reviewed publication in the field, and Blood Advances (bloodadvances.org) is an open-access, online journal that publishes more peer-reviewed hematology research than any other academic journal worldwide. Two new journals will be joining the Blood Journals portfolio in 2024, Blood Neoplasia (bloodneoplasia.org) and Blood Vessels, Thrombosis & Hemostasis (bloodvth.org).
View original content to download multimedia:https://www.prnewswire.com/news-releases/studies-highlight-impacts-of-applying-new-technologies-in-everyday-care-302010724.html
SOURCE American Society of Hematology
Serious News for Serious Traders! Try StreetInsider.com Premium Free!
You May Also Be Interested In
- America Ferrera and Jessica Chastain Shine in De Beers at the 2024 SAG Awards
- FII PRIORITY SUMMIT IN MIAMI CONCLUDES WITH URGENT CALL FOR ACTION AND PROGRESS ON AI ALIGNMENT
- HONOR Debuts a New AI-empowered All-scenario Strategy at MWC 2024
Create E-mail Alert Related CategoriesPRNewswire, Press Releases
Related EntitiesCarl Icahn, Twitter
Sign up for StreetInsider Free!
Receive full access to all new and archived articles, unlimited portfolio tracking, e-mail alerts, custom newswires and RSS feeds - and more!