Quantum-Si partners with Cell Signaling Technology for protein analysis

Quantum-Si Incorporated (NASDAQ: QSI) announced a partnership with Cell Signaling Technology to develop and validate protein sequencing and post-translational modification analysis on its Proteus single-molecule protein sequencing platform.

The collaboration will integrate Cell Signaling Technology's post-translational modification detection and immunoaffinity enrichment capabilities with Quantum-Si's Proteus workflows. The partnership aims to enable site-resolved detection and quantitation of proteins and post-translational modifications for research applications.

Cell Signaling Technology specializes in recombinant monoclonal antibodies, kits, and services for scientific research. The company developed PTMScan proteomics technology, which combines post-translational modification-specific immunoaffinity enrichment with mass spectrometry and bioinformatics.

The collaboration will proceed in two phases. In the first phase, Cell Signaling Technology will generate characterized post-translational modification-enriched samples and datasets to support development of Quantum-Si's protein sequencing workflows. The data will be used to build Quantum-Si's kinetic signature database and automated analysis methods.

The second phase will compare results from the Proteus platform with mass spectrometry data generated by Cell Signaling Technology to benchmark performance and validate the platform's capabilities.

"We are excited to partner with CST on the development and validation of our PTM capabilities on Proteus," said Jeff Hawkins, President and Chief Executive Officer of Quantum-Si. "CST is a global leader in the field of PTM discovery and analysis."

Roberto Polakiewicz, Chief Scientific Officer at Cell Signaling Technology, said the partnership aims to "support new ways of interrogating complex biological systems and complement existing mass-spectrometry-based proteomics workflows."

The information is based on a press release statement from Quantum-Si.

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