Gain Therapeutics (GANX) Presents GT-02287 Data

Gain Therapeutics, Inc. (Nasdaq: GANX) today announces the presentation of a poster at the Federation of European Neuroscience Societies (FENS) Forum 2024. The poster describes improvement in cognitive performance and activities of daily living associated with administration of GT-02287 the Company’s lead novel allosteric therapeutic candidate in a mouse model of GBA1-Parkinson's disease (GBA1-PD). FENS Forum 2024 is being held June 25–29, 2024 in Vienna, Austria.

“These data further confirm our conviction that GT-02287 can slow or stop progression of Parkinson’s disease and given the cognitive decline observed in GBA1 Parkinson’s patients, we hope that we can one day deliver this drug to those that need it and help them improve their everyday life. As we are completing our Phase 1 clinical study, we look forward to evaluating this drug in patients suffering from this chronic and debilitating disease with no adequate treatment options,” commented Dr. Joanne Taylor, Senior Vice President of Research at Gain Therapeutics. “FENS Forum 2024 is an important opportunity for us to continue discussing our differentiated approach to addressing GBA1 Parkinson’s disease and further discourse and collaboration with the neuroscience community.”

The poster, titled, “GT-02287, a Clinical-Stage GCase Enhancer, Improves Activities of Daily Living and Cognitive Performance in a Preclinical Model of GBA1 Parkinson’s disease,” which will be presented on-site on June 27th by Dr. Beatriz Calvo-Flores Guzman and available online the same day demonstrates how GT-02287 improves nest-building performance and motor performance in a mouse model of GBA1-PD. Nest building in rodents is a natural and spontaneous behavior that closely resembles the tasks of daily living and cognitive performance in humans. GT-02287 was administrated orally once daily from day eight in a mouse model of GBA1-PD, which utilizes a combination of α-synuclein pre-formed fibril (PFF) administration and glucocerebrosidase (GCase) activity lowering with conduritol beta epoxide (CBE). Nest-building performance was assessed by scoring the quality of the nest and motor function was tested in the wire hang test at day 28. Plasma NfL, and brain aggregated alpha-synuclein, Iba-1, and GFAP levels were also measured. The results suggest that GT-02287 can rescue deficits in complex behaviors in which cognitive function is involved in a GBA1 Parkinson’s disease model in addition to improving motor function deficits in this model as reported previously and this is reflected in appropriate biomarker changes.

A PDF of the poster presented at the FENS Forum 2024 conference is available on the Science & Technology section of the Company’s website at https://www.gaintherapeutics.com/science-and-technology/posters.

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