Dyadic International, Inc. (DYAI) Announces Leadership Change

Dyadic International, Inc. (Nasdaq: DYAI) today announced a leadership change as part of its ongoing strategic shift to evolve into a revenue-generating provider of ancillary recombinant protein products supporting the life sciences, nutrition, and industrial markets. Dyadic’s Board of Directors, which has overseen and endorsed this strategy, has appointed Joe Hazelton as President, effective immediately. Mr. Hazelton will also continue in his role as Chief Operating Officer.

Over the past 18 months, Dyadic has made a deliberate pivot to prioritize near-term commercialization opportunities in high-growth, high-value segments such as cell culture media, DNA/RNA technologies, and non-animal food and nutrition ingredients. This pivot has achieved commercial validation through the consummation of high value transactions in the ancillary protein space, including a develop-and-commercialize partnership with Proliant Health and Biologicals for recombinant human albumin, a collaboration with a non-animal dairy enzyme company, and a joint venture with Fermbox Bio that led to the launch of EN3ZYME, recently resulting in a significant purchase order in the cellulosic enzyme market.

“We believe the achievement of these milestones validates our strategy and reflects the growing demand for ancillary recombinant proteins,” said Mark Emalfarb, Dyadic’s Founder and Chief Executive Officer. “We previously communicated an initial focus in the ancillary protein space, we have successfully executed on key initial agreements, and now we are reaffirming that focus by aligning our leadership team to accelerate growth. Joe’s appointment as President ensures focused and prioritized execution across Dyadic’s technical, operational and commercial efforts.”

As President, Joe Hazelton will be responsible for scaling Dyadic’s scientific and commercial initiatives, deepening industry partnerships, oversight of daily operations and ensuring efficient execution of the business strategy. In support of this strategic shift, Joe will also guide Dyadic’s corporate rebranding efforts.

“We see this as a pivotal moment for Dyadic,” said Joe Hazelton, Dyadic’s President and COO. “We’ve proven the commercial readiness of our platforms with valuable partnerships and revenue. Now we’re aligning our organization to scale and expand across the life sciences, food, and nutrition markets. I look forward to working with our leadership team to work to accelerate this momentum, drive operational execution, and deliver tangible value to our shareholders.”

Dyadic’s C1 and Dapibus™ platforms—already central to its recent commercial successes—continue to underpin the Company’s strategy, offering differentiated, large-scale, high-titer production of recombinant proteins across targeted non-therapeutic markets.

While the significant majority of Dyadic’s focus will be on the compelling ancillary protein opportunity, legacy biopharmaceutical programs remain active, with Mr. Emalfarb (who will continue to serve as Chief Executive Officer and a member of the Board of Directors) overseeing their development in addition to his continued focus on funding/investment opportunities, IP strategy, and legacy projects.

Joe Hazelton joined Dyadic in 2021 as Chief Business Officer and was promoted to Chief Operating Officer in 2024. His experience includes over two decades of leadership in biotech commercialization, with a proven track record of strategic execution at both Dyadic and Novartis.

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