DarioHealth publishes diabetes study on 22,000+ users

DarioHealth Corp. (NASDAQ: DRIO) announced the publication of peer-reviewed research in Frontiers in Digital Health examining blood glucose improvements among users of its diabetes management platform.

The observational study analyzed real-world data from 22,414 adults with type 2 diabetes and baseline blood glucose levels in the high-risk range. Researchers used machine learning models and longitudinal mixed-effects analyses to identify glycemic trajectories influenced by demographic, clinical and engagement factors.

The study found that higher levels of digital engagement, specifically frequent blood glucose monitoring and lifestyle activity tracking, were associated with stronger glycemic improvements. Researchers identified 12 measurements per month as a threshold for glycemic improvement.

"Our findings reinforce that engagement is not just a usage metric – it is a clinical signal," said Yifat Hershcovitz, VP Clinical & Scientific Affairs at Dario and senior author of the study. "We observed a substantial early reduction in blood glucose followed by sustained stabilization, particularly among users who monitored consistently and engaged with lifestyle tools."

The research used generalized linear mixed-effects tree models to identify factors that influence glycemic improvement outcomes. The study showed no meaningful body mass index difference across ethnicities among users.

"This study demonstrates that digital health platforms can move beyond one-size-fits-all approaches," said Omar Manejwala, Chief Medical Officer of Dario. "By applying machine learning to real-world data at scale, we can identify which users respond best, when intervention is most impactful and how engagement behaviors influence outcomes."

DarioHealth provides digital health solutions for diabetes, hypertension, weight management, musculoskeletal pain and behavioral health to health plans, employers, healthcare providers and consumers globally.

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