OPKO's ModeX partners with Regeneron on multispecific antibodies

ModeX Therapeutics, a subsidiary of OPKO Health Inc. (NASDAQ: OPK), entered into a license and collaboration agreement with Regeneron Pharmaceuticals Inc. (NASDAQ: REGN) to develop multispecific antibodies for therapeutic applications.

Under the agreement terms, ModeX receives $7 million upfront and potential milestone payments exceeding $200 million per selected molecule. The collaboration's total value could exceed $1 billion if multiple products advance successfully. ModeX is also eligible for tiered global net sales royalties up to low double digits at the highest tier.

The partnership combines ModeX's MSTAR platform with Regeneron's proprietary binders to create multispecific antibody candidates targeting multiple biological pathways in a single molecule. Regeneron will fund and lead preclinical, clinical development and commercialization activities for any products it chooses to advance.

The collaboration will explore applications in immunology, oncology and metabolic diseases. ModeX's MSTAR platform generates multispecific antibodies from modular building blocks designed to modulate potency and maximize specificity across multiple disease pathways simultaneously.

"This agreement allows us to work closely with Regeneron, world leaders in the development of antibody medicines, to explore the promise of multispecific antibodies in new indications," said Gary Nabel, President and CEO of ModeX and Chief Innovation Officer of OPKO Health.

ModeX Therapeutics is a clinical-stage biopharmaceutical company developing multispecific biologics for cancer and infectious disease. The company's pipeline includes candidates against solid and hematologic tumors and viral threats.

The information is based on a press release statement from the companies.

You May Also Be Interested In

• SpaceX files for 555.56M share IPO at $135/sh
• Alnylam partners with Inceptive in $2B AI collaboration for drug discovery
• Loop Industries receives C$2.92 million government funding for recycling tech