Form 497 Voya PARTNERS INC

VOYA PARTNERS, INC.

VY® Invesco Comstock Portfolio

(the “Portfolio”)

Supplement dated November 21, 2025

to the Portfolio’s Adviser Class, Initial Class, and Service Class Shares’

Prospectus, dated May 1, 2025

(the “Prospectus”)

Effective November 5, 2025, Umang Khetan, CFA, was added as a portfolio manager for the Portfolio.

Effective immediately, the Prospectus is revised as follows:

1.The sub-section of the Prospectus entitled “Portfolio Management – Portfolio Managers” in the Portfolio’s Summary Section is deleted in its entirety and replaced with the following:

2.The table in the sub-section of the Prospectus entitled “Management of the Portfolios – Portfolio Management” is amended to include the following:

PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE

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VOYA PARTNERS, INC.

VY® Invesco Comstock Portfolio

(the “Portfolio”)

Supplement dated November 21, 2025

to the Portfolio’s Adviser Class, Initial Class, and Service Class Shares’

Statement of Additional Information, dated May 1, 2025

(the “SAI”)

Effective November 5, 2025, Umang Khetan, CFA, was added as a portfolio manager for the Portfolio.

Effective immediately, the SAI is revised as follows:

1.The table in the sub-section of the SAI entitled “Portfolio Management – Other Accounts Managed” is amended to include the following:

Invesco

2 As of August 31, 2025.

2. The table in the sub-section of the SAI entitled “Portfolio Management – Ownership of Securities” is amended to include the following:

1 As of August 31, 2025.

PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE

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