Amarin Corp. (AMRN) Reports Publication of MARINE Phase 3 Data
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Amarin Corporation plc (Nasdaq: AMRN), announced that results of its pivotal MARINE Phase 3 clinical trial were published in the September issue of The American Journal of Cardiology. The Company also reported, as previously announced, that data from the Company's Phase 3 MARINE trial was presented at the European Society of Cardiology (ESC) Congress 2011.
The publication titled, Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients with Very High Triglyceride Levels (From the MARINE Trial), provides a peer-reviewed summary of the previously reported Phase 3 MARINE clinical trial data of Amarin's lead product candidate AMR101, in which a statistically significant reduction in triglyceride levels and other lipid parameters was observed without a statistically significant increase in LDL-cholesterol. This is the first peer-reviewed publication of the results from this trial, the largest conducted in the patient population studied (TG >500mg/dL). As previously announced, the primary endpoint of this study was successfully achieved at daily doses of both 2 grams and 4 grams of AMR101. The results also suggest that AMR101was safe and well tolerated.
The Company also summarized additional results of the MARINE trial results as presented this week at the European Society of Cardiology (ESC) Congress, including new data presented on reductions in high-sensitive C-reactive protein (hs-CRP). Elevated hs-CRP is associated with vascular inflammation. Separately, data was presented indicating that AMR101 significantly increased, in a dose-dependent manner, the EPA concentration in plasma and red blood cells.
The publication titled, Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients with Very High Triglyceride Levels (From the MARINE Trial), provides a peer-reviewed summary of the previously reported Phase 3 MARINE clinical trial data of Amarin's lead product candidate AMR101, in which a statistically significant reduction in triglyceride levels and other lipid parameters was observed without a statistically significant increase in LDL-cholesterol. This is the first peer-reviewed publication of the results from this trial, the largest conducted in the patient population studied (TG >500mg/dL). As previously announced, the primary endpoint of this study was successfully achieved at daily doses of both 2 grams and 4 grams of AMR101. The results also suggest that AMR101was safe and well tolerated.
The Company also summarized additional results of the MARINE trial results as presented this week at the European Society of Cardiology (ESC) Congress, including new data presented on reductions in high-sensitive C-reactive protein (hs-CRP). Elevated hs-CRP is associated with vascular inflammation. Separately, data was presented indicating that AMR101 significantly increased, in a dose-dependent manner, the EPA concentration in plasma and red blood cells.
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