Kadmon (KDMN) Commences Dosing in Tesevatinib Phase 2
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Kadmon Initiates Phase 2 Clinical Trial Evaluating Tesevatinib in Glioblastoma
August 29, 2016 9:00 AM EDTNEW YORK--(BUSINESS WIRE)-- Kadmon Holdings, Inc. (NYSE: KDMN) today announced that the first patient has been dosed in a Phase 2 clinical trial of tesevatinib, the Companys oral tyrosine kinase inhibitor, for the treatment of recurrent glioblastoma. The open-label, multicenter study examines tesevatinib monotherapy administered at 300 mg once daily in up to 40 patients in the United States.
Tesevatinib is an oral inhibitor of epidermal growth factor receptor (EGFR), a cell surface receptor whose gene is amplified in more than 50% of gliomas. Unlike other EGFR inhibitors, tesevatinib has been observed in animal... More