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Insmed (INSM) PT Lowered to $203 at BofA Securities

December 18, 2025 6:17 AM EST
Get Alerts INSM Hot Sheet
Price: $134.52 +1.47%

Rating Summary:
    32 Buy, 1 Hold, 1 Sell

Rating Trend: Up Up

Today's Overall Ratings:
    Up: 11 | Down: 16 | New: 6
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BofA Securities lowered the price target on Insmed (NASDAQ: INSM) to $203.00 (from $214.00) while maintaining a Buy rating.

The analyst comments "Yesterday afternoon, Insmed (INSM) reported BiRCH, its phase 2b of brensocatib in CRSsNP, missed all efficacy endpoints, with the company ending development in the indication. INSM shares are -15% post market (After hours close $160.25), and while some of this likely reflects ongoing YE trading dynamics, we’d argue the selloff is overdone. We recognize the disappointment given a potential TAM larger than NCFB, with Insmed reporting positive blended/ blinded efficacy trends in the meantime. That said, the team had long admitted the study was high risk given a lack of pre-clinical support (there are no animal models), with KOLs warning the role of neutrophils in the disease is variable. Thus, while today’s results are a setback for Insmed, it was never a driver of our positive thesis—nor, we’d argue, most of the Street as well."



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