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   <title>ZYUS reports Phase 2a trial results for non-opioid cancer pain drug</title>
   <link>http://www.streetinsider.com/FDA/ZYUS+reports+Phase+2a+trial+results+for+non-opioid+cancer+pain+drug/27131950.html</link>
   <description>

&lt;p&gt;ZYUS Life Sciences Corporation (TSXV: ZYUS) reported topline results from its Phase 2a UTOPIA-1 clinical trial evaluating Trichomylin® softgel capsules in patients with advanced cancer experiencing moderate to severe cancer-related pain, according to a press release issued Oct. 1, 2026.&lt;/p&gt;

&lt;p&gt;The trial enrolled 11 patients across three Canadian sites — McGill University Health Center, CancerCare Manitoba, and Centre Hospitalier de l'Université de Montreal. All patients were maintained on standard-of-care pain management, including long-acting opioids, throughout the trial. Of the 11 enrolled, 91% successfully titrated to an individualized, stable dose, and no treatment-related serious adverse events were observed.&lt;/p&gt;

&lt;p&gt;In a subset of seven</description>
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   <pubDate>Thu, 01 Oct 2026 08:10:11 -0400</pubDate>
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   <title>ZYUS Life Sciences Announces Positive Topline Results from Phase 2a UTOPIA-1 Trial Evaluating Novel Non-Opioid Pain Drug in Patients with Advanced Cancer</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Announces+Positive+Topline+Results+from+Phase+2a+UTOPIA-1+Trial+Evaluating+Novel+Non-Opioid+Pain+Drug+in+Patients+with+Advanced+Cancer/27131948.html</link>
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                  &lt;li&gt;Phase 2a UTOPIA-1 trial results showed Trichomylin® softgel capsules demonstrated clinically relevant efficacy signals using multiple pain assessments.&lt;/li&gt;
                  &lt;li&gt;Trichomylin® softgel capsules were well-tolerated, with no related serious adverse events observed, supporting the sustainability of an individualized titration dosing regimen.&lt;/li&gt;
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   <pubDate>Thu, 01 Oct 2026 08:09:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Announces Positive Topline Results from Phase 2a UTOPIA-1 Trial Evaluating Novel Non-Opioid Pain Drug in Patients with Advanced Cancer</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Announces+Positive+Topline+Results+from+Phase+2a+UTOPIA-1+Trial+Evaluating+Novel+Non-Opioid+Pain+Drug+in+Patients+with+Advanced+Cancer/27131948.html</link>
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                &lt;ul type=&quot;disc&quot;&gt;
                  &lt;li&gt;Phase 2a UTOPIA-1 trial results showed Trichomylin® softgel capsules demonstrated clinically relevant efficacy signals using multiple pain assessments.&lt;/li&gt;
                  &lt;li&gt;Trichomylin® softgel capsules were well-tolerated, with no related serious adverse events observed, supporting the sustainability of an individualized titration dosing regimen.&lt;/li&gt;
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <pubDate>Tue, 05 May 2026 18:00:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
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&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <pubDate>Tue, 05 May 2026 18:00:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <pubDate>Tue, 05 May 2026 18:00:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <pubDate>Tue, 05 May 2026 18:00:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Expands U.S. Patent Portfolio with Second Pain Management Patent</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Expands+U.S.+Patent+Portfolio+with+Second+Pain+Management+Patent/26436802.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Issuance of &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; patent supports ongoing clinical research in chronic and neuropathic pain &lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;May 5, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - &lt;span value=&quot;TorontoVE:ZYUS&quot; idsrc=&quot;xmltag.org&quot; &gt;ZYUS Life Sciences Corporation&lt;/span&gt; (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, announced today that the United States Patent and Trademark Office (&quot;USPTO&quot;) has issued &lt;location value=&quot;LC/us&quot; idsrc=&quot;xmltag.org&quot; &gt;U.S.&lt;/location&gt; Patent No. 12,616,704, entitled CANNABICHROMENE FORMULATION FOR PAIN MANAGEMENT on today's date.  The patent, held by ZYUS' wholly owned subsidiary, &lt;span&gt;ZYUS Life Sciences</description>
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   <pubDate>Tue, 05 May 2026 18:00:00 -0400</pubDate>
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   <title>ZYUS reports early data from cancer pain drug trial</title>
   <link>http://www.streetinsider.com/FDA/ZYUS+reports+early+data+from+cancer+pain+drug+trial/25824444.html</link>
   <description>

&lt;p&gt;ZYUS Life Sciences Corporation (TSXV: ZYUS) announced preliminary results from its Phase 2a UTOPIA-1 trial evaluating Trichomylin softgel capsules in patients with moderate to severe cancer-related pain.&lt;/p&gt;

&lt;p&gt;The preliminary data is based on the first 25% of enrolled patients who completed treatment in the single-arm, proof-of-concept study. According to the company, early results showed reductions in average daily pain, pain interference, and pain severity. The trial also recorded reductions in opioid dosing for breakthrough pain.&lt;/p&gt;

&lt;p&gt;The company reported no serious adverse events related to Trichomylin softgel capsules. Most adverse reactions were described as mild and occurred during dose titration, consistent with the</description>
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   <pubDate>Thu, 08 Jan 2026 09:24:06 -0400</pubDate>
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   <title>ZYUS reports early data from cancer pain drug trial</title>
   <link>http://www.streetinsider.com/FDA/ZYUS+reports+early+data+from+cancer+pain+drug+trial/25824444.html</link>
   <description>

&lt;p&gt;ZYUS Life Sciences Corporation (TSXV: ZYUS) announced preliminary results from its Phase 2a UTOPIA-1 trial evaluating Trichomylin softgel capsules in patients with moderate to severe cancer-related pain.&lt;/p&gt;

&lt;p&gt;The preliminary data is based on the first 25% of enrolled patients who completed treatment in the single-arm, proof-of-concept study. According to the company, early results showed reductions in average daily pain, pain interference, and pain severity. The trial also recorded reductions in opioid dosing for breakthrough pain.&lt;/p&gt;

&lt;p&gt;The company reported no serious adverse events related to Trichomylin softgel capsules. Most adverse reactions were described as mild and occurred during dose titration, consistent with the</description>
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   <title>ZYUS Life Sciences Reports Preliminary Results from Ongoing Phase 2a UTOPIA-1 Trial Evaluating Novel Non-Opioid Pain Drug</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Reports+Preliminary+Results+from+Ongoing+Phase+2a+UTOPIA-1+Trial+Evaluating+Novel+Non-Opioid+Pain+Drug/25824443.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Early Data Suggests a Trend Toward Improvement in Pain Efficacy&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Jan. 8, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced favourable preliminary results from its ongoing Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) trial evaluating Trichomylin® softgel capsules in patients experiencing moderate to severe cancer-related pain.&lt;/p&gt;
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   <title>ZYUS Life Sciences Reports Preliminary Results from Ongoing Phase 2a UTOPIA-1 Trial Evaluating Novel Non-Opioid Pain Drug</title>
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&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Early Data Suggests a Trend Toward Improvement in Pain Efficacy&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Jan. 8, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced favourable preliminary results from its ongoing Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) trial evaluating Trichomylin® softgel capsules in patients experiencing moderate to severe cancer-related pain.&lt;/p&gt;
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&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Early Data Suggests a Trend Toward Improvement in Pain Efficacy&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Jan. 8, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced favourable preliminary results from its ongoing Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) trial evaluating Trichomylin® softgel capsules in patients experiencing moderate to severe cancer-related pain.&lt;/p&gt;
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&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Early Data Suggests a Trend Toward Improvement in Pain Efficacy&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Jan. 8, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &quot;Company&quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced favourable preliminary results from its ongoing Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) trial evaluating Trichomylin® softgel capsules in patients experiencing moderate to severe cancer-related pain.&lt;/p&gt;
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   <title>ZYUS Life Sciences enrolls first patient in cancer pain trial</title>
   <link>http://www.streetinsider.com/FDA/ZYUS+Life+Sciences+enrolls+first+patient+in+cancer+pain+trial/25249416.html</link>
   <description>

&lt;p&gt;ZYUS Life Sciences Corporation (TSXV: ZYUS) has activated its first clinical site and enrolled the first patient in its Phase 2a UTOPIA-1 cancer pain trial, according to a company statement released August 26.&lt;/p&gt;

&lt;p&gt;The Centre Hospitalier de l'Université de Montréal serves as the initial clinical site for the single-arm, proof-of-concept study. The trial is designed to investigate the safety and preliminary analgesic efficacy of Trichomylin softgel capsules in patients with advanced cancer and moderate to severe cancer-related pain.&lt;/p&gt;

&lt;p&gt;UTOPIA-1 stands for Unique Treatment of Oncology Pain in Advanced Cancer. The hospital continues to actively recruit additional patients for the study.&lt;/p&gt;

&lt;p&gt;&quot;Activating our first</description>
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   <pubDate>Tue, 26 Aug 2025 07:00:32 -0400</pubDate>
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   <title>ZYUS Life Sciences enrolls first patient in cancer pain trial</title>
   <link>http://www.streetinsider.com/FDA/ZYUS+Life+Sciences+enrolls+first+patient+in+cancer+pain+trial/25249416.html</link>
   <description>

&lt;p&gt;ZYUS Life Sciences Corporation (TSXV: ZYUS) has activated its first clinical site and enrolled the first patient in its Phase 2a UTOPIA-1 cancer pain trial, according to a company statement released August 26.&lt;/p&gt;

&lt;p&gt;The Centre Hospitalier de l'Université de Montréal serves as the initial clinical site for the single-arm, proof-of-concept study. The trial is designed to investigate the safety and preliminary analgesic efficacy of Trichomylin softgel capsules in patients with advanced cancer and moderate to severe cancer-related pain.&lt;/p&gt;

&lt;p&gt;UTOPIA-1 stands for Unique Treatment of Oncology Pain in Advanced Cancer. The hospital continues to actively recruit additional patients for the study.&lt;/p&gt;

&lt;p&gt;&quot;Activating our first</description>
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   <pubDate>Tue, 26 Aug 2025 07:00:32 -0400</pubDate>
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   <title>ZYUS Life Sciences Activates First Clinical Site and Enrolls First Patient in Phase 2a UTOPIA-1 Cancer Pain Trial</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Activates+First+Clinical+Site+and+Enrolls+First+Patient+in+Phase+2a+UTOPIA-1+Cancer+Pain+Trial/25249409.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;

&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Phase 2a trial designed to investigate the safety and preliminary analgesic efficacy of Trichomylin® softgel capsules &lt;/i&gt;&lt;/p&gt;
&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 26, 2025&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &amp;quot;Company&amp;quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced the activation of the Centre Hospitalier de l&amp;#39;Université de &lt;location value=&quot;LU/ca.qc.montrl&quot; idsrc=&quot;xmltag.org&quot; &gt;Montréal&lt;/location&gt; (&amp;quot;CHUM&amp;quot;) as first clinical site in its Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) clinical trial.&lt;/p&gt;

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   <pubDate>Tue, 26 Aug 2025 07:00:00 -0400</pubDate>
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   <title>ZYUS Life Sciences Activates First Clinical Site and Enrolls First Patient in Phase 2a UTOPIA-1 Cancer Pain Trial</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Activates+First+Clinical+Site+and+Enrolls+First+Patient+in+Phase+2a+UTOPIA-1+Cancer+Pain+Trial/25249409.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;

&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Phase 2a trial designed to investigate the safety and preliminary analgesic efficacy of Trichomylin® softgel capsules &lt;/i&gt;&lt;/p&gt;
&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 26, 2025&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &amp;quot;Company&amp;quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced the activation of the Centre Hospitalier de l&amp;#39;Université de &lt;location value=&quot;LU/ca.qc.montrl&quot; idsrc=&quot;xmltag.org&quot; &gt;Montréal&lt;/location&gt; (&amp;quot;CHUM&amp;quot;) as first clinical site in its Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) clinical trial.&lt;/p&gt;

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   <title>ZYUS Life Sciences Activates First Clinical Site and Enrolls First Patient in Phase 2a UTOPIA-1 Cancer Pain Trial</title>
   <link>http://www.streetinsider.com/Press+Releases/ZYUS+Life+Sciences+Activates+First+Clinical+Site+and+Enrolls+First+Patient+in+Phase+2a+UTOPIA-1+Cancer+Pain+Trial/25249409.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;

&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Phase 2a trial designed to investigate the safety and preliminary analgesic efficacy of Trichomylin® softgel capsules &lt;/i&gt;&lt;/p&gt;
&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 26, 2025&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &amp;quot;Company&amp;quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced the activation of the Centre Hospitalier de l&amp;#39;Université de &lt;location value=&quot;LU/ca.qc.montrl&quot; idsrc=&quot;xmltag.org&quot; &gt;Montréal&lt;/location&gt; (&amp;quot;CHUM&amp;quot;) as first clinical site in its Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) clinical trial.&lt;/p&gt;

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   <title>ZYUS Life Sciences Activates First Clinical Site and Enrolls First Patient in Phase 2a UTOPIA-1 Cancer Pain Trial</title>
   <link>http://www.streetinsider.com/PRNewswire/ZYUS+Life+Sciences+Activates+First+Clinical+Site+and+Enrolls+First+Patient+in+Phase+2a+UTOPIA-1+Cancer+Pain+Trial/25249409.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;

&lt;p class=&quot;prntac&quot;&gt;&lt;i&gt;Phase 2a trial designed to investigate the safety and preliminary analgesic efficacy of Trichomylin® softgel capsules &lt;/i&gt;&lt;/p&gt;
&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/ca.sk.sasoon&quot; idsrc=&quot;xmltag.org&quot; &gt;SASKATOON, SK&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 26, 2025&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ - ZYUS Life Sciences Corporation (the &amp;quot;Company&amp;quot;) (TSXV: ZYUS), a clinical-stage life sciences company focused on the development and commercialization of novel non-opioid drug candidates for pain management, today announced the activation of the Centre Hospitalier de l&amp;#39;Université de &lt;location value=&quot;LU/ca.qc.montrl&quot; idsrc=&quot;xmltag.org&quot; &gt;Montréal&lt;/location&gt; (&amp;quot;CHUM&amp;quot;) as first clinical site in its Phase 2a UTOPIA-1 (Unique Treatment of Oncology Pain in Advanced Cancer) clinical trial.&lt;/p&gt;

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