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si-local-file:///var/storage/secattach/20260610/26630558.html http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+09++Filed+by%3A+Vitorovic+Stefan/26630558.html Wed, 10 Jun 2026 16:45:00 -0400 O.29707909 TECX http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+09++Filed+by%3A+Vitorovic+Stefan/26630558.html si-local-file:///var/storage/secattach/20260610/26630558.html http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+09++Filed+by%3A+Vitorovic+Stefan/26630558.html Wed, 10 Jun 2026 16:45:00 -0400 O.29707909 TECX http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630438.html si-local-file:///var/storage/secattach/20260610/26630438.html http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630438.html Wed, 10 Jun 2026 16:36:00 -0400 O.29707909 TECX http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630438.html si-local-file:///var/storage/secattach/20260610/26630438.html http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630438.html Wed, 10 Jun 2026 16:36:00 -0400 O.29707909 TECX http://www.streetinsider.com/SEC+Filings/Form++3++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630425.html si-local-file:///var/storage/secattach/20260610/26630425.html http://www.streetinsider.com/SEC+Filings/Form++3++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630425.html Wed, 10 Jun 2026 16:35:00 -0400 O.29707909 TECX http://www.streetinsider.com/SEC+Filings/Form++3++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630425.html si-local-file:///var/storage/secattach/20260610/26630425.html http://www.streetinsider.com/SEC+Filings/Form++3++++++++++Tectonic+Therapeutic%2C+++++For%3A+Jun+08++Filed+by%3A+Chutter+Jessica+Caroline/26630425.html Wed, 10 Jun 2026 16:35:00 -0400 O.29707909 TECX http://www.streetinsider.com/FDA/Tectonic+Therapeutic+completes+enrollment+in+TX45+phase+2+trial/26629714.html <p>Tectonic Therapeutic Inc. (NASDAQ: TECX) completed enrollment in its APEX Phase 2 clinical trial evaluating TX45 in patients with pulmonary hypertension associated with heart failure with preserved ejection fraction.</p> <p>The 24-week trial enrolled 191 patients across 14 countries, with 137 patients having combined pre- and post-capillary pulmonary hypertension and pulmonary vascular resistance greater than 3 Wood Units at baseline. This population represents approximately 72% of total enrolled patients.</p> <p>The randomized, double-blind, placebo-controlled trial is testing two dose regimens of TX45 administered subcutaneously. Patients receive either 300 mg monthly, 300 mg every other week, or placebo. The primary endpoint measures change from baseline http://www.streetinsider.com/FDA/Tectonic+Therapeutic+completes+enrollment+in+TX45+phase+2+trial/26629714.html Wed, 10 Jun 2026 16:01:13 -0400 TECX http://www.streetinsider.com/Press+Releases/Tectonic+Therapeutic+Completes+Enrollment+in+TX45+APEX+Phase+2+Clinical+Trial+in+PH-HFpEF+Patients/26629708.html <ul><li>APEX 24-week Phase 2 trial is evaluating the safety and efficacy of TX45 in patients with pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF)</li><li style="margin-bottom:8pt;">APEX Phase 2 trial enrolled 191 patients across 14 countries, with approximately 72% of patients in the enriched population of CpcPH with a pulmonary vascular resistance (PVR) <u>&gt;</u>3 WU at baseline</li><li style="margin-bottom:8pt;">TX45 APEX Phase 2 topline results expected in early Q1 2027<br /><br /></li></ul> <p>WATERTOWN, Mass., June 10, 2026 (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=3B-hTUX_k0WdbY3nuGhxn7lCWyCFP6RsEGlYPQBevQH2b3x_83B66oi3cPrcL3JTRyVnQY2NfE-UPwuyp97uthucew06OWi38CQ1HSYN9to=" rel="nofollow" target="_blank">Tectonic Therapeutic, Inc. </a>(NASDAQ: TECX) (“Tectonic” or the “Company”), a clinical stage biotechnology company focused on http://www.streetinsider.com/Press+Releases/Tectonic+Therapeutic+Completes+Enrollment+in+TX45+APEX+Phase+2+Clinical+Trial+in+PH-HFpEF+Patients/26629708.html Wed, 10 Jun 2026 16:01:00 -0400 TECX http://www.streetinsider.com/Globe+Newswire/Tectonic+Therapeutic+Completes+Enrollment+in+TX45+APEX+Phase+2+Clinical+Trial+in+PH-HFpEF+Patients/26629708.html <ul><li>APEX 24-week Phase 2 trial is evaluating the safety and efficacy of TX45 in patients with pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF)</li><li style="margin-bottom:8pt;">APEX Phase 2 trial enrolled 191 patients across 14 countries, with approximately 72% of patients in the enriched population of CpcPH with a pulmonary vascular resistance (PVR) <u>&gt;</u>3 WU at baseline</li><li style="margin-bottom:8pt;">TX45 APEX Phase 2 topline results expected in early Q1 2027<br /><br /></li></ul> <p>WATERTOWN, Mass., June 10, 2026 (GLOBE NEWSWIRE) -- <a href="https://www.globenewswire.com/Tracker?data=3B-hTUX_k0WdbY3nuGhxn7lCWyCFP6RsEGlYPQBevQH2b3x_83B66oi3cPrcL3JTRyVnQY2NfE-UPwuyp97uthucew06OWi38CQ1HSYN9to=" rel="nofollow" target="_blank">Tectonic Therapeutic, Inc. </a>(NASDAQ: TECX) (“Tectonic” or the “Company”), a clinical stage biotechnology company focused on http://www.streetinsider.com/Globe+Newswire/Tectonic+Therapeutic+Completes+Enrollment+in+TX45+APEX+Phase+2+Clinical+Trial+in+PH-HFpEF+Patients/26629708.html Wed, 10 Jun 2026 16:01:00 -0400 TECX