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   <title>Spyre (SYRE) PT Raised to $120 at Mizuho</title>
   <link>http://www.streetinsider.com/Analyst+PT+Change/Spyre+%28SYRE%29+PT+Raised+to+%24120+at+Mizuho/26759437.html</link>
   <description>(Updated - July 13, 2026 6:46 AM EDT)

&lt;p&gt;Mizuho analyst Joseph Catanzaro raised the price target on Spyre (NASDAQ: SYRE) to $120.00 (from $84.00) while maintaining a Outperform rating.&lt;/p&gt;&lt;p&gt;The analyst commented: &quot;Following a series of internal/external updates, as well as KOL feedback on dual pathway inhibition in IBD that strongly aligns with what SYRE has spoken to (note here), we're raising our PT to $120 from $84. We believe recent SKYLINE Part A data for SPY001 and SPY002 positions SPY120 for clinical remission rates that will have a high probability of showing superiority over an active monotherapy comparator. Such a profile</description>
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   <pubDate>Mon, 13 Jul 2026 06:46:05 -0400</pubDate>
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   <title>Spyre (SYRE) PT Raised to $120 at Mizuho</title>
   <link>http://www.streetinsider.com/Analyst+Comments/Spyre+%28SYRE%29+PT+Raised+to+%24120+at+Mizuho/26759437.html</link>
   <description>(Updated - July 13, 2026 6:46 AM EDT)

&lt;p&gt;Mizuho analyst Joseph Catanzaro raised the price target on Spyre (NASDAQ: SYRE) to $120.00 (from $84.00) while maintaining a Outperform rating.&lt;/p&gt;&lt;p&gt;The analyst commented: &quot;Following a series of internal/external updates, as well as KOL feedback on dual pathway inhibition in IBD that strongly aligns with what SYRE has spoken to (note here), we're raising our PT to $120 from $84. We believe recent SKYLINE Part A data for SPY001 and SPY002 positions SPY120 for clinical remission rates that will have a high probability of showing superiority over an active monotherapy comparator. Such a profile</description>
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   <pubDate>Mon, 13 Jul 2026 06:46:05 -0400</pubDate>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jul 01  Filed by: Burrows Scott L</title>
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   <pubDate>Thu, 02 Jul 2026 21:34:00 -0400</pubDate>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jul 01  Filed by: Burrows Scott L</title>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jul 01  Filed by: Sloan Sheldon</title>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jul 01  Filed by: Turtle Cameron</title>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jul 01  Filed by: Turtle Cameron</title>
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   <title>Spyre Therapeutics Announces Grants of Inducement Awards</title>
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&lt;p align=&quot;left&quot;&gt;WALTHAM, Mass., July  02, 2026  (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre’s independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase an aggregate of 58,843 shares of common stock of Spyre and 2,134 restricted stock units (“RSUs”) to six non-executive employees as equity inducement awards under the Spyre Therapeutics, Inc. 2018</description>
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   <title>Spyre Therapeutics Announces Grants of Inducement Awards</title>
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&lt;p align=&quot;left&quot;&gt;WALTHAM, Mass., July  02, 2026  (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre’s independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase an aggregate of 58,843 shares of common stock of Spyre and 2,134 restricted stock units (“RSUs”) to six non-executive employees as equity inducement awards under the Spyre Therapeutics, Inc. 2018</description>
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   <title>Spyre Therapeutics Announces Grants of Inducement Awards</title>
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&lt;p align=&quot;left&quot;&gt;WALTHAM, Mass., July  02, 2026  (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre’s independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase an aggregate of 58,843 shares of common stock of Spyre and 2,134 restricted stock units (“RSUs”) to six non-executive employees as equity inducement awards under the Spyre Therapeutics, Inc. 2018</description>
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   <title>Spyre Therapeutics Announces Grants of Inducement Awards</title>
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&lt;p align=&quot;left&quot;&gt;WALTHAM, Mass., July  02, 2026  (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre’s independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase an aggregate of 58,843 shares of common stock of Spyre and 2,134 restricted stock units (“RSUs”) to six non-executive employees as equity inducement awards under the Spyre Therapeutics, Inc. 2018</description>
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   <title>Form  144        Spyre Therapeutics, Inc.               Filed by: Turtle Cameron</title>
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   <title>Form  4          Spyre Therapeutics, Inc.  For: Jun 25  Filed by: Burrows Scott L</title>
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   <title>Spyre Therapeutics (SYRE) files mixed shelf</title>
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   <description>&lt;p&gt;Spyre Therapeutics (NASDAQ: SYRE) has filed mixed shelf of:&lt;/p&gt;&lt;p&gt;COMMON STOCK&lt;br /&gt;PREFERRED STOCK&lt;br /&gt;DEBT SECURITIES&lt;br /&gt;WARRANTS&lt;br /&gt;UNITS&lt;br /&gt; &lt;/p&gt;</description>
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   <description>&lt;p&gt;Spyre Therapeutics (NASDAQ: SYRE) has filed mixed shelf of:&lt;/p&gt;&lt;p&gt;COMMON STOCK&lt;br /&gt;PREFERRED STOCK&lt;br /&gt;DEBT SECURITIES&lt;br /&gt;WARRANTS&lt;br /&gt;UNITS&lt;br /&gt; &lt;/p&gt;</description>
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   <title>Form  144        Spyre Therapeutics, Inc.               Filed by: Burrows Scott L</title>
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