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   <title>Oragenics signs letter of intent to license blood purification technology</title>
   <link>http://www.streetinsider.com/Corporate+News/Oragenics+signs+letter+of+intent+to+license+blood+purification+technology/26449181.html</link>
   <description>&lt;p&gt;Oragenics Inc. (NYSE American: OGEN) signed a letter of intent to license CardioDialysis technology from Sigyn Therapeutics Inc. (OTCQB: SIGY) for treating traumatic brain injury and other chronic neurodegenerative diseases, according to a company statement.&lt;/p&gt;&lt;p&gt;The proposed exclusive license would allow Oragenics to develop and commercialize the blood purification technology, which removes inflammatory and pathogenic molecules from the bloodstream. The company plans to combine this approach with its existing ONP-002 neurosteroid treatment, currently in Phase IIa clinical trials for concussion and mild traumatic brain injury.&lt;/p&gt;&lt;p&gt;Under the proposed terms, Oragenics would issue 3.25 million shares of restricted preferred stock to Sigyn, convertible</description>
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   <title>Oragenics signs letter of intent to license blood purification technology</title>
   <link>http://www.streetinsider.com/Corporate+News/Oragenics+signs+letter+of+intent+to+license+blood+purification+technology/26449181.html</link>
   <description>&lt;p&gt;Oragenics Inc. (NYSE American: OGEN) signed a letter of intent to license CardioDialysis technology from Sigyn Therapeutics Inc. (OTCQB: SIGY) for treating traumatic brain injury and other chronic neurodegenerative diseases, according to a company statement.&lt;/p&gt;&lt;p&gt;The proposed exclusive license would allow Oragenics to develop and commercialize the blood purification technology, which removes inflammatory and pathogenic molecules from the bloodstream. The company plans to combine this approach with its existing ONP-002 neurosteroid treatment, currently in Phase IIa clinical trials for concussion and mild traumatic brain injury.&lt;/p&gt;&lt;p&gt;Under the proposed terms, Oragenics would issue 3.25 million shares of restricted preferred stock to Sigyn, convertible</description>
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   <title>Oragenics signs letter of intent to license blood purification technology</title>
   <link>http://www.streetinsider.com/Corporate+News/Oragenics+signs+letter+of+intent+to+license+blood+purification+technology/26449181.html</link>
   <description>&lt;p&gt;Oragenics Inc. (NYSE American: OGEN) signed a letter of intent to license CardioDialysis technology from Sigyn Therapeutics Inc. (OTCQB: SIGY) for treating traumatic brain injury and other chronic neurodegenerative diseases, according to a company statement.&lt;/p&gt;&lt;p&gt;The proposed exclusive license would allow Oragenics to develop and commercialize the blood purification technology, which removes inflammatory and pathogenic molecules from the bloodstream. The company plans to combine this approach with its existing ONP-002 neurosteroid treatment, currently in Phase IIa clinical trials for concussion and mild traumatic brain injury.&lt;/p&gt;&lt;p&gt;Under the proposed terms, Oragenics would issue 3.25 million shares of restricted preferred stock to Sigyn, convertible</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Press+Releases/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Press+Releases/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Press+Releases/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Press+Releases/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Press+Releases/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Globe+Newswire/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Globe+Newswire/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Globe+Newswire/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
   <link>http://www.streetinsider.com/Globe+Newswire/Oragenics+Signs+Letter+of+Intent+to+License+CardioDialysis%E2%84%A2+Technology+from+Sigyn+Therapeutics+to+Target+TBI-Induced+Systemic+Inflammation/26449135.html</link>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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   <title>Oragenics Signs Letter of Intent to License CardioDialysis™ Technology from Sigyn Therapeutics to Target TBI-Induced Systemic Inflammation</title>
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&lt;p align=&quot;justify&quot;&gt;&lt;i&gt;The Expected License Agreement Would Position Oragenics as the Only Company with Therapeutic Strategies Targeting TBI-Induced Inflammation on Both Sides of the Blood-Brain Barrier&lt;/i&gt;&lt;/p&gt;  &lt;p align=&quot;justify&quot;&gt;&lt;strong&gt;Sarasota, FL and San Diego, CA, May  07, 2026  (GLOBE NEWSWIRE) -- &lt;/strong&gt;Oragenics, Inc. (NYSE American: OGEN) (&amp;quot;Oragenics&amp;quot; or the &amp;quot;Company&amp;quot;), a clinical-stage biopharmaceutical company pioneering neurological therapeutics, and Sigyn Therapeutics, Inc. (OTCQB: SIGY) (“Sigyn”), a developer of extracorporeal therapies, today announced the signing of a Letter of Intent (&amp;quot;LOI&amp;quot;) under which Oragenics expects to license from Sigyn, certain disease indications of CardioDialysis™, a blood purification technology that enables the broad-spectrum</description>
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&lt;p&gt;SAN DIEGO, CA - April 2, 2026 (NEWMEDIAWIRE) - Sigyn Therapeutics, Inc. (Sigyn or the Company) (OTCQB: SIGY), developer of CardioDialysis(TM), a medical device that enables continuous broad-spectrum clearance of inflammatory and pathogenic molecules from the bloodstream, today announced the launch of an initiative to evaluate emerging medical technologies in former NFL players at risk of chronic traumatic encephalopathy (CTE). &lt;/p&gt;&lt;p&gt;Former NFL players experience significantly higher rates of neurodegenerative diseases as compared to the general population. Among these are amyotrophic lateral sclerosis (ALS), Parkinsons disease, and CTE, which has been diagnosed post-mortem in a majority of former NFL players. &lt;/p&gt;&lt;p&gt;While</description>
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