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Form 4 Septerna, Inc. For: Jul 15 Filed by: Bhatt Elizabeth

Fri, 17 Jul 2026 19:01:00 -0400

si-local-file:///var/storage/secattach/20260717/26785417.html

Form 4 Septerna, Inc. For: Jul 15 Filed by: Bhatt Elizabeth

Fri, 17 Jul 2026 19:01:00 -0400

si-local-file:///var/storage/secattach/20260717/26785417.html

Form 144 Septerna, Inc. Filed by: Bhatt Elizabeth

Wed, 15 Jul 2026 16:23:00 -0400

si-local-file:///var/storage/secattach/20260715/26774416.html

Form 144 Septerna, Inc. Filed by: Bhatt Elizabeth

Wed, 15 Jul 2026 16:23:00 -0400

si-local-file:///var/storage/secattach/20260715/26774416.html

Form 4 Septerna, Inc. For: Jul 01 Filed by: Long Daniel D.

Thu, 02 Jul 2026 19:00:00 -0400

si-local-file:///var/storage/secattach/20260702/26730043.html

Form 4 Septerna, Inc. For: Jul 01 Filed by: Long Daniel D.

Thu, 02 Jul 2026 19:00:00 -0400

si-local-file:///var/storage/secattach/20260702/26730043.html

H.C. Wainwright Reiterates Buy Rating on Septerna Inc (SEPN)

Wed, 01 Jul 2026 06:59:09 -0400

H.C. Wainwright analyst Raghuram Selvaraju reiterated a Buy rating and $40.00 price target on Septerna Inc (NASDAQ: SEPN).

The analyst commented: "Evommune (EVMN; Neutral) recently reported negative Phase 2b data with EVO756, an MRGPRX2 antagonist, in chronic spontaneous urticaria (CSU). Ahead of this readout, Evommune believed that EVO756 had risk-mitigated target engagement through three linked datasets: a human icatibant skin-challenge study showing that the drug engaged MRGPRX2; an interstitial-fluid assessment showing meaningful skin penetration; and positive chronic inducible urticaria (CIndU) activity that supported symptom relevance. The CSU miss cuts directly against the company’s translational bridge: acute MRGPRX2 blockade in a provoked

Septerna Inc (SEPN) PT Lowered to $45 at Guggenheim

Wed, 01 Jul 2026 06:40:15 -0400

(Updated - July 1, 2026 6:40 AM EDT)

Guggenheim analyst Seamus Fernandez lowered the price target on Septerna Inc (NASDAQ: SEPN) to $45.00 (from $52.00) while maintaining a Buy rating.

The analyst commented: "This past Monday, EVMN announced top-line results for their Ph2b CSU study of MRGPRX2 inhibitor, EVO756. The study did not meet the primary endpoint of change in UAS7 at 12 weeks and EVMN has DC'd efforts in CSU. We caught up with SEPN mgmt whose confidence in SEP-631's potential superiority as a molecule matches our own, the team agreed there is substantially increased risk in running a CSU study

Septerna Inc (SEPN) PT Lowered to $45 at Guggenheim

Wed, 01 Jul 2026 06:40:15 -0400

(Updated - July 1, 2026 6:40 AM EDT)

Guggenheim analyst Seamus Fernandez lowered the price target on Septerna Inc (NASDAQ: SEPN) to $45.00 (from $52.00) while maintaining a Buy rating.

Septerna Inc (SEPN) PT Raised to $43 at Truist Securities

Wed, 01 Jul 2026 04:37:12 -0400

Truist Securities analyst Srikripa Devarakonda raised the price target on Septerna Inc (NASDAQ: SEPN) to $43.00 (from $35.00) while maintaining a Buy rating.

The analyst comments "We revisited our SEPN model and are updating it to reflect updated thoughts on the stock - 1) We believe investor focus now is on HP with Ph1 HV readout expected YE2026/1H2027. Based on TAM for HP, HV data with first-gen HP asset, preclinical data indicating activity, & potentially better safety for second-gen asset, we now assign POS for HP to 35% from 20% and as we head closer to data YE26/1H27; 2) Following competitor's

Septerna Inc (SEPN) PT Raised to $43 at Truist Securities

Wed, 01 Jul 2026 04:37:12 -0400

Truist Securities analyst Srikripa Devarakonda raised the price target on Septerna Inc (NASDAQ: SEPN) to $43.00 (from $35.00) while maintaining a Buy rating.

Form 4 Septerna, Inc. For: Jun 26 Filed by: Shah Rajeev M.

Tue, 30 Jun 2026 19:52:00 -0400

si-local-file:///var/storage/secattach/20260630/26715209.html

Form 4 Septerna, Inc. For: Jun 26 Filed by: Shah Rajeev M.

Tue, 30 Jun 2026 19:52:00 -0400

si-local-file:///var/storage/secattach/20260630/26715209.html

Form 4 Septerna, Inc. For: Jun 29 Filed by: Shaikhly Samira

Tue, 30 Jun 2026 19:02:00 -0400

si-local-file:///var/storage/secattach/20260630/26715158.html

Form 4 Septerna, Inc. For: Jun 29 Filed by: Shaikhly Samira

Tue, 30 Jun 2026 19:02:00 -0400

si-local-file:///var/storage/secattach/20260630/26715158.html

Form 4 Septerna, Inc. For: Jun 26 Filed by: Ezekowitz Alan