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   <title>LifeSci Capital Starts Obsidian Therapeutics (OBX) at Outperform</title>
   <link>http://www.streetinsider.com/New+Coverage/LifeSci+Capital+Starts+Obsidian+Therapeutics+%28OBX%29+at+Outperform/26940203.html</link>
   <description>&lt;p&gt;LifeSci Capital initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Outperform rating and a price target of $43.00.&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For more ratings news on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/stock_lookup_news.php?q=OBX&amp;amp;type=analyst&quot;&gt;click here&lt;/a&gt;.&lt;/p&gt;&lt;p&gt;Shares of Obsidian Therapeutics closed at $17.54 yesterday.&lt;/p&gt;</description>
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   <pubDate>Tue, 18 Aug 2026 06:23:44 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  10-Q       Obsidian Therapeutics,    For: Jun 30</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++10-Q+++++++Obsidian+Therapeutics%2C++++For%3A+Jun+30/26931430.html</link>
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   <pubDate>Fri, 14 Aug 2026 16:32:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  8-K/A      Obsidian Therapeutics,    For: Jul 31</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-KA++++++Obsidian+Therapeutics%2C++++For%3A+Jul+31/26931482.html</link>
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   <pubDate>Fri, 14 Aug 2026 16:32:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Deep Track Capital, LP</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Deep+Track+Capital%2C+LP/26905494.html</link>
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   <pubDate>Tue, 11 Aug 2026 16:04:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Atlas Venture Fund X, L.P.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Atlas+Venture+Fund+X%2C+L.P./26898748.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:44:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: RA CAPITAL MANAGEMENT, L.P.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+RA+CAPITAL+MANAGEMENT%2C+L.P./26898333.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:24:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Novo Holdings A/S</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Novo+Holdings+AS/26898295.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:22:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>TD Cowen Starts Obsidian Therapeutics (OBX) at Buy</title>
   <link>http://www.streetinsider.com/New+Coverage/TD+Cowen+Starts+Obsidian+Therapeutics+%28OBX%29+at+Buy/26877167.html</link>
   <description>(Updated - August 6, 2026 5:30 AM EDT)

&lt;p&gt;TD Cowen analyst Tyler Van Buren initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst comments &quot;Amsoki-cel’s next-gen design combining IL-15 regulation with core needle biopsy supports a best-in-class TIL profile. An unprecedented 67% ORR in mCM was achieved with improved safety as IL-2 maintenance is not required. Beyond melanoma, early data and TIL validation support expansion into the large NSCLC market. The world-class management team and our $4B+ peak sales est. support our Buy rating.&quot;&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For</description>
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   <pubDate>Thu, 06 Aug 2026 05:30:53 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>TD Cowen Starts Obsidian Therapeutics (OBX) at Buy</title>
   <link>http://www.streetinsider.com/Analyst+Comments/TD+Cowen+Starts+Obsidian+Therapeutics+%28OBX%29+at+Buy/26877167.html</link>
   <description>(Updated - August 6, 2026 5:30 AM EDT)

&lt;p&gt;TD Cowen analyst Tyler Van Buren initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst comments &quot;Amsoki-cel’s next-gen design combining IL-15 regulation with core needle biopsy supports a best-in-class TIL profile. An unprecedented 67% ORR in mCM was achieved with improved safety as IL-2 maintenance is not required. Beyond melanoma, early data and TIL validation support expansion into the large NSCLC market. The world-class management team and our $4B+ peak sales est. support our Buy rating.&quot;&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For</description>
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   <pubDate>Thu, 06 Aug 2026 05:30:53 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: ROSS ROBERT W.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+ROSS+ROBERT+W./26874299.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:11:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Jagasia Madan</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Jagasia+Madan/26874202.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:09:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Norkunas Matthew</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Norkunas+Matthew/26874208.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:09:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Barrett Peter</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Barrett+Peter/26874165.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:08:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Hagen Heidi</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Hagen+Heidi/26874014.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:06:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Fardis Maria</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Fardis+Maria/26873940.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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  <item>
   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   	  </item>
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   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
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   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
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   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Piper Sandler Starts Obsidian Therapeutics (OBX) at Overweight</title>
   <link>http://www.streetinsider.com/New+Coverage/Piper+Sandler+Starts+Obsidian+Therapeutics+%28OBX%29+at+Overweight/26868831.html</link>
   <description>&lt;p&gt;Piper Sandler analyst Kelsey Goodwin initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Overweight rating and a price target of $42.00.&lt;/p&gt;&lt;p&gt;The analyst comments: “OBX is a clinical stage biotech company advancing next generation, engineered tumor infiltrating lymphocyte (TIL) cell therapies. TIL therapy has been clinically validated as an effective autologous immunotherapy in solid tumors since the pioneering work of Dr. Steven Rosenberg and his colleagues at the NIH back in the 1980s. TIL therapy is particularly well suited for solid tumors given: (1) the broad repertoire of naturally-occurring TCRs including those recognizing neoantigens [none of which need to be</description>
   <guid isPermaLink="true">http://www.streetinsider.com/New+Coverage/Piper+Sandler+Starts+Obsidian+Therapeutics+%28OBX%29+at+Overweight/26868831.html</guid>
   <pubDate>Wed, 05 Aug 2026 02:37:22 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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