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   <title>Ideaya Biosciences (IDYA) Reiterated at Overweight by Cantor Fitzgerald </title>
   <link>http://www.streetinsider.com/Analyst+Comments/Ideaya+Biosciences+%28IDYA%29+Reiterated+at+Overweight+by+Cantor+Fitzgerald+/26595094.html</link>
   <description>&lt;p&gt;Cantor Fitzgerald analyst Li Watsek reiterated an Overweight rating on Ideaya Biosciences (NASDAQ: IDYA).&lt;/p&gt;&lt;p&gt;The analyst commented, &quot;We hosted CEO Yujiro Hata, CMO Darrrin Beaupre, CCO Stu Dorman, and SVP of clinical dev Jasgit Sachdev for a wellattended dinner at ASCO (6/1). It was on the back of darovasertib's (daro) Ph2/3 OptimUM-02 data presentation as a latebreaker abstract at the conference, a monumental milestone for IDEAYA as a company, and for patients with metastatic uveal melanoma (MUM). Not surprisingly, there was a fair amount of discussion on the approval and launch details of daro in 1L MUM. What's a little surprising</description>
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   <pubDate>Wed, 03 Jun 2026 06:48:43 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>Form  8-K        IDEAYA Biosciences, Inc.  For: Jun 03</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++IDEAYA+Biosciences%2C+Inc.++For%3A+Jun+03/26594891.html</link>
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   <pubDate>Wed, 03 Jun 2026 06:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.28729778</category>
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   <title>Form  8-K        IDEAYA Biosciences, Inc.  For: Jun 03</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++IDEAYA+Biosciences%2C+Inc.++For%3A+Jun+03/26594891.html</link>
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   <pubDate>Wed, 03 Jun 2026 06:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.28729778</category>
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   <title>IDEAYA Biosciences partners with Roche for pancreatic cancer study</title>
   <link>http://www.streetinsider.com/Corporate+News/IDEAYA+Biosciences+partners+with+Roche+for+pancreatic+cancer+study/26594631.html</link>
   <description>&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) entered into a clinical collaboration with Roche to evaluate a combination therapy for patients with pancreatic ductal adenocarcinoma that carries specific genetic mutations.&lt;/p&gt;&lt;p&gt;The collaboration will test IDE892, IDEAYA's investigational PRMT5 inhibitor currently in Phase 1 trials, combined with RG6505, Roche's Phase 1 pan-RAS inhibitor. The study targets patients with MTAP-deleted, RAS-mutant pancreatic ductal adenocarcinoma.&lt;/p&gt;&lt;p&gt;IDEAYA will sponsor the clinical trial while Roche will supply RG6505. Both companies will maintain joint governance to oversee the study and retain all commercial rights to their respective compounds.&lt;/p&gt;&lt;p&gt;MTAP deletion occurs in up to 40% of pancreatic ductal adenocarcinoma cases, according</description>
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   <pubDate>Wed, 03 Jun 2026 06:00:41 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>IDEAYA Biosciences Announces Clinical Collaboration with Roche in MTAP-Deleted RAS-Mutant Pancreatic Cancer</title>
   <link>http://www.streetinsider.com/Press+Releases/IDEAYA+Biosciences+Announces+Clinical+Collaboration+with+Roche+in+MTAP-Deleted+RAS-Mutant+Pancreatic+Cancer/26594606.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;IDEAYA entered into a clinical collaboration with Roche to evaluate IDE892, IDEAYA's potential best-in-class Phase 1 MTA-cooperative PRMT5 inhibitor, in combination with RG6505, Roche's Phase 1 pan-RAS inhibitor, in MTAP-deleted, RAS-mutant pancreatic ductal adenocarcinoma&lt;/li&gt;&lt;li&gt;IDEAYA will sponsor the clinical trial, and there will be joint IDEAYA and Roche governance to oversee the study&lt;/li&gt;&lt;li&gt;MTAP-deletion is estimated to occur in up to 40% of PDAC&lt;/li&gt;&lt;/ul&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/us.ca.sousco&quot; idsrc=&quot;xmltag.org&quot; &gt;SOUTH SAN FRANCISCO, Calif.&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;June 3, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;NASDAQ-NMS:IDYA&quot; idsrc=&quot;xmltag.org&quot; &gt;IDEAYA Biosciences, Inc.&lt;/span&gt; (NASDAQ: IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, announced it</description>
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   <pubDate>Wed, 03 Jun 2026 06:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>IDEAYA Biosciences Announces Clinical Collaboration with Roche in MTAP-Deleted RAS-Mutant Pancreatic Cancer</title>
   <link>http://www.streetinsider.com/Press+Releases/IDEAYA+Biosciences+Announces+Clinical+Collaboration+with+Roche+in+MTAP-Deleted+RAS-Mutant+Pancreatic+Cancer/26594606.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;IDEAYA entered into a clinical collaboration with Roche to evaluate IDE892, IDEAYA's potential best-in-class Phase 1 MTA-cooperative PRMT5 inhibitor, in combination with RG6505, Roche's Phase 1 pan-RAS inhibitor, in MTAP-deleted, RAS-mutant pancreatic ductal adenocarcinoma&lt;/li&gt;&lt;li&gt;IDEAYA will sponsor the clinical trial, and there will be joint IDEAYA and Roche governance to oversee the study&lt;/li&gt;&lt;li&gt;MTAP-deletion is estimated to occur in up to 40% of PDAC&lt;/li&gt;&lt;/ul&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/us.ca.sousco&quot; idsrc=&quot;xmltag.org&quot; &gt;SOUTH SAN FRANCISCO, Calif.&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;June 3, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;NASDAQ-NMS:IDYA&quot; idsrc=&quot;xmltag.org&quot; &gt;IDEAYA Biosciences, Inc.&lt;/span&gt; (NASDAQ: IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, announced it</description>
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   <pubDate>Wed, 03 Jun 2026 06:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>IDEAYA Biosciences Announces Clinical Collaboration with Roche in MTAP-Deleted RAS-Mutant Pancreatic Cancer</title>
   <link>http://www.streetinsider.com/PRNewswire/IDEAYA+Biosciences+Announces+Clinical+Collaboration+with+Roche+in+MTAP-Deleted+RAS-Mutant+Pancreatic+Cancer/26594606.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;IDEAYA entered into a clinical collaboration with Roche to evaluate IDE892, IDEAYA's potential best-in-class Phase 1 MTA-cooperative PRMT5 inhibitor, in combination with RG6505, Roche's Phase 1 pan-RAS inhibitor, in MTAP-deleted, RAS-mutant pancreatic ductal adenocarcinoma&lt;/li&gt;&lt;li&gt;IDEAYA will sponsor the clinical trial, and there will be joint IDEAYA and Roche governance to oversee the study&lt;/li&gt;&lt;li&gt;MTAP-deletion is estimated to occur in up to 40% of PDAC&lt;/li&gt;&lt;/ul&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/us.ca.sousco&quot; idsrc=&quot;xmltag.org&quot; &gt;SOUTH SAN FRANCISCO, Calif.&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;June 3, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;NASDAQ-NMS:IDYA&quot; idsrc=&quot;xmltag.org&quot; &gt;IDEAYA Biosciences, Inc.&lt;/span&gt; (NASDAQ: IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, announced it</description>
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   <pubDate>Wed, 03 Jun 2026 06:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.28729778</category>
   	  </item>
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   <title>IDEAYA Biosciences Announces Clinical Collaboration with Roche in MTAP-Deleted RAS-Mutant Pancreatic Cancer</title>
   <link>http://www.streetinsider.com/PRNewswire/IDEAYA+Biosciences+Announces+Clinical+Collaboration+with+Roche+in+MTAP-Deleted+RAS-Mutant+Pancreatic+Cancer/26594606.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;IDEAYA entered into a clinical collaboration with Roche to evaluate IDE892, IDEAYA's potential best-in-class Phase 1 MTA-cooperative PRMT5 inhibitor, in combination with RG6505, Roche's Phase 1 pan-RAS inhibitor, in MTAP-deleted, RAS-mutant pancreatic ductal adenocarcinoma&lt;/li&gt;&lt;li&gt;IDEAYA will sponsor the clinical trial, and there will be joint IDEAYA and Roche governance to oversee the study&lt;/li&gt;&lt;li&gt;MTAP-deletion is estimated to occur in up to 40% of PDAC&lt;/li&gt;&lt;/ul&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/us.ca.sousco&quot; idsrc=&quot;xmltag.org&quot; &gt;SOUTH SAN FRANCISCO, Calif.&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;June 3, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;NASDAQ-NMS:IDYA&quot; idsrc=&quot;xmltag.org&quot; &gt;IDEAYA Biosciences, Inc.&lt;/span&gt; (NASDAQ: IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, announced it</description>
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   <pubDate>Wed, 03 Jun 2026 06:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.28729778</category>
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   <title>Ideaya Biosciences (IDYA) Reiterated at Market Outperform by Citizens </title>
   <link>http://www.streetinsider.com/Analyst+Comments/Ideaya+Biosciences+%28IDYA%29+Reiterated+at+Market+Outperform+by+Citizens+/26586173.html</link>
   <description>&lt;p&gt;Citizens analyst Silvan Turkcan reiterated a Market Outperform rating and $45.00 price target on Ideaya Biosciences (NASDAQ: IDYA).&lt;/p&gt;&lt;p&gt;The analyst commented, &quot;IDEAYA Biosciences' ASCO update on OptimUM-02 data provided additional color on the strength of results, including safety and a highly favorable serious adverse event profile compared to checkpoint inhibitors. We highlight that the ~7-month PFS value is &gt;2.2 times the current SoC, significant progress in the management of metastatic uveal melanoma (MUM). IDYA is moving toward regulatory approval via the RTOR process, expected to complete in 2H26 and set up a potential 2027 launch. We maintain our Market Outperform rating</description>
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   <pubDate>Tue, 02 Jun 2026 04:30:01 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>Form  8-K        IDEAYA Biosciences, Inc.  For: Jun 01</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++IDEAYA+Biosciences%2C+Inc.++For%3A+Jun+01/26583528.html</link>
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   <pubDate>Mon, 01 Jun 2026 16:07:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>Form  8-K        IDEAYA Biosciences, Inc.  For: Jun 01</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++IDEAYA+Biosciences%2C+Inc.++For%3A+Jun+01/26583528.html</link>
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   <pubDate>Mon, 01 Jun 2026 16:07:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">IDYA</category>
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   <title>IDEAYA reports positive phase 2/3 trial results for uveal melanoma drug</title>
   <link>http://www.streetinsider.com/FDA/IDEAYA+reports+positive+phase+23+trial+results+for+uveal+melanoma+drug/26581127.html</link>
   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

&lt;p&gt;The study enrolled 313 patients randomized 2:1 to receive either the darovasertib combination or investigator's choice therapy, which included</description>
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   <title>IDEAYA reports positive phase 2/3 trial results for uveal melanoma drug</title>
   <link>http://www.streetinsider.com/FDA/IDEAYA+reports+positive+phase+23+trial+results+for+uveal+melanoma+drug/26581127.html</link>
   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

&lt;p&gt;The study enrolled 313 patients randomized 2:1 to receive either the darovasertib combination or investigator's choice therapy, which included</description>
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   <title>IDEAYA reports positive phase 2/3 trial results for uveal melanoma drug</title>
   <link>http://www.streetinsider.com/FDA/IDEAYA+reports+positive+phase+23+trial+results+for+uveal+melanoma+drug/26581127.html</link>
   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

&lt;p&gt;The study enrolled 313 patients randomized 2:1 to receive either the darovasertib combination or investigator's choice therapy, which included</description>
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   <title>IDEAYA reports positive phase 2/3 trial results for uveal melanoma drug</title>
   <link>http://www.streetinsider.com/FDA/IDEAYA+reports+positive+phase+23+trial+results+for+uveal+melanoma+drug/26581127.html</link>
   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

&lt;p&gt;The study enrolled 313 patients randomized 2:1 to receive either the darovasertib combination or investigator's choice therapy, which included</description>
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&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

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&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

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&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

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   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

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   <title>IDEAYA reports positive phase 2/3 trial results for uveal melanoma drug</title>
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   <description>

&lt;p&gt;IDEAYA Biosciences Inc. (NASDAQ: IDYA) and Servier reported results from their phase 2/3 OptimUM-02 trial of darovasertib in combination with crizotinib for first-line treatment of HLA*A2:01 negative metastatic uveal melanoma at the American Society of Clinical Oncology Annual Meeting.&lt;/p&gt;

&lt;p&gt;The trial met its primary endpoint, showing median progression-free survival of 6.9 months for the darovasertib combination versus 3.1 months for investigator's choice therapy, representing a 58% reduction in disease progression risk. The hazard ratio was 0.42 with a p-value of less than 0.0001.&lt;/p&gt;

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&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;Darovasertib combination resulted in a statistically significant and clinically meaningful improvement in median PFS vs. investigator's choice of therapy (ICT) – 6.9 months vs. 3.1 months, HR: 0.42, 58% reduction in risk of disease progression&lt;/li&gt;&lt;li&gt;Significantly improved ORR (37.1% vs 5.8%) and DCR (73.3% vs. 31.1%) by BICR vs. ICT, where ~77% were treated with ipilimumab + nivolumab&lt;/li&gt;&lt;li&gt;OS not yet mature but early trend favoring the darovasertib combination; targeting to provide the next update as part of the pre-specified interim analysis  &lt;/li&gt;&lt;li&gt;Manageable safety profile consistent with prior results, with a low rate of TR-SAE (9.2%) and discontinuations due to TRAEs</description>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;Darovasertib combination resulted in a statistically significant and clinically meaningful improvement in median PFS vs. investigator's choice of therapy (ICT) – 6.9 months vs. 3.1 months, HR: 0.42, 58% reduction in risk of disease progression&lt;/li&gt;&lt;li&gt;Significantly improved ORR (37.1% vs 5.8%) and DCR (73.3% vs. 31.1%) by BICR vs. ICT, where ~77% were treated with ipilimumab + nivolumab&lt;/li&gt;&lt;li&gt;OS not yet mature but early trend favoring the darovasertib combination; targeting to provide the next update as part of the pre-specified interim analysis  &lt;/li&gt;&lt;li&gt;Manageable safety profile consistent with prior results, with a low rate of TR-SAE (9.2%) and discontinuations due to TRAEs</description>
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&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;Darovasertib combination resulted in a statistically significant and clinically meaningful improvement in median PFS vs. investigator's choice of therapy (ICT) – 6.9 months vs. 3.1 months, HR: 0.42, 58% reduction in risk of disease progression&lt;/li&gt;&lt;li&gt;Significantly improved ORR (37.1% vs 5.8%) and DCR (73.3% vs. 31.1%) by BICR vs. ICT, where ~77% were treated with ipilimumab + nivolumab&lt;/li&gt;&lt;li&gt;OS not yet mature but early trend favoring the darovasertib combination; targeting to provide the next update as part of the pre-specified interim analysis  &lt;/li&gt;&lt;li&gt;Manageable safety profile consistent with prior results, with a low rate of TR-SAE (9.2%) and discontinuations due to TRAEs</description>
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&lt;ul type=&quot;disc&quot;&gt;&lt;li&gt;Darovasertib combination resulted in a statistically significant and clinically meaningful improvement in median PFS vs. investigator's choice of therapy (ICT) – 6.9 months vs. 3.1 months, HR: 0.42, 58% reduction in risk of disease progression&lt;/li&gt;&lt;li&gt;Significantly improved ORR (37.1% vs 5.8%) and DCR (73.3% vs. 31.1%) by BICR vs. ICT, where ~77% were treated with ipilimumab + nivolumab&lt;/li&gt;&lt;li&gt;OS not yet mature but early trend favoring the darovasertib combination; targeting to provide the next update as part of the pre-specified interim analysis  &lt;/li&gt;&lt;li&gt;Manageable safety profile consistent with prior results, with a low rate of TR-SAE (9.2%) and discontinuations due to TRAEs</description>
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