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   <title>Form  4          Amylyx Pharmaceuticals,   For: Jul 09  Filed by: Mazzariello Gina</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Amylyx+Pharmaceuticals%2C+++For%3A+Jul+09++Filed+by%3A+Mazzariello+Gina/26762381.html</link>
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   <pubDate>Mon, 13 Jul 2026 16:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
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   <title>Form  4          Amylyx Pharmaceuticals,   For: Jul 09  Filed by: Mazzariello Gina</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Amylyx+Pharmaceuticals%2C+++For%3A+Jul+09++Filed+by%3A+Mazzariello+Gina/26762381.html</link>
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   <pubDate>Mon, 13 Jul 2026 16:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
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   <title>Form  144        Amylyx Pharmaceuticals,                Filed by: Mazzariello Gina</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++144++++++++Amylyx+Pharmaceuticals%2C++++++++++++++++Filed+by%3A+Mazzariello+Gina/26753516.html</link>
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   <pubDate>Thu, 09 Jul 2026 16:26:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
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   <title>Form  144        Amylyx Pharmaceuticals,                Filed by: Mazzariello Gina</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++144++++++++Amylyx+Pharmaceuticals%2C++++++++++++++++Filed+by%3A+Mazzariello+Gina/26753516.html</link>
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   <pubDate>Thu, 09 Jul 2026 16:26:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
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   <title>Amylyx Pharmaceuticals inc. (AMLX) PT Raised to $40 at Guggenheim</title>
   <link>http://www.streetinsider.com/Analyst+PT+Change/Amylyx+Pharmaceuticals+inc.+%28AMLX%29+PT+Raised+to+%2440+at+Guggenheim/26688310.html</link>
   <description>(Updated - June 25, 2026 7:40 AM EDT)

&lt;p&gt;Guggenheim analyst Seamus Fernandez raised the price target on Amylyx Pharmaceuticals inc. (NASDAQ: AMLX) to $40.00 (from $30.00) while maintaining a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst commented: &quot;We are elevating AMLX to our BEST IDEA (from Top Pick) and raising our PT to $40 (from $30) ahead of the pivotal Phase 3 LUCIDITY readout in 3Q26 for avexitide in PBH. We strongly believe LUCIDITY will be positive and pave the way for AMLX to dominate the $6B+ US PBH market for years to come. Our model updates reflect: (1) Increased GLP-1R antagonism penetration in severe</description>
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   <pubDate>Thu, 25 Jun 2026 07:40:19 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
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   <title>Amylyx Pharmaceuticals inc. (AMLX) PT Raised to $40 at Guggenheim</title>
   <link>http://www.streetinsider.com/Analyst+Comments/Amylyx+Pharmaceuticals+inc.+%28AMLX%29+PT+Raised+to+%2440+at+Guggenheim/26688310.html</link>
   <description>(Updated - June 25, 2026 7:40 AM EDT)

&lt;p&gt;Guggenheim analyst Seamus Fernandez raised the price target on Amylyx Pharmaceuticals inc. (NASDAQ: AMLX) to $40.00 (from $30.00) while maintaining a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst commented: &quot;We are elevating AMLX to our BEST IDEA (from Top Pick) and raising our PT to $40 (from $30) ahead of the pivotal Phase 3 LUCIDITY readout in 3Q26 for avexitide in PBH. We strongly believe LUCIDITY will be positive and pave the way for AMLX to dominate the $6B+ US PBH market for years to come. Our model updates reflect: (1) Increased GLP-1R antagonism penetration in severe</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Analyst+Comments/Amylyx+Pharmaceuticals+inc.+%28AMLX%29+PT+Raised+to+%2440+at+Guggenheim/26688310.html</guid>
   <pubDate>Thu, 25 Jun 2026 07:40:19 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
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   <title>Amylyx ALS drug shows no serious adverse events in Phase 1 trial</title>
   <link>http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</link>
   <description>

&lt;p&gt;Amylyx Pharmaceuticals (NASDAQ: AMLX) presented early data from the Phase 1 LUMINA trial of its investigational drug AMX0114 for amyotrophic lateral sclerosis (ALS) at the European Network to Cure ALS (ENCALS) Meeting 2026 in Madrid, Spain.&lt;/p&gt;

&lt;p&gt;In Cohort 1, which evaluated the lowest dose level of 12.5 mg in 12 participants, AMX0114 showed no drug-related serious adverse events and no serious neurological adverse events. Biomarker levels, including spectrin breakdown product 145, neurofilament light, and phosphorylated neurofilament heavy, remained near baseline.&lt;/p&gt;

&lt;p&gt;LUMINA (NCT06665165) is a multinational, randomized, double-blind, placebo-controlled, multiple ascending dose trial evaluating AMX0114 across four dose levels. The trial is expected</description>
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   <pubDate>Tue, 23 Jun 2026 07:00:26 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
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   <title>Amylyx ALS drug shows no serious adverse events in Phase 1 trial</title>
   <link>http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</link>
   <description>

&lt;p&gt;Amylyx Pharmaceuticals (NASDAQ: AMLX) presented early data from the Phase 1 LUMINA trial of its investigational drug AMX0114 for amyotrophic lateral sclerosis (ALS) at the European Network to Cure ALS (ENCALS) Meeting 2026 in Madrid, Spain.&lt;/p&gt;

&lt;p&gt;In Cohort 1, which evaluated the lowest dose level of 12.5 mg in 12 participants, AMX0114 showed no drug-related serious adverse events and no serious neurological adverse events. Biomarker levels, including spectrin breakdown product 145, neurofilament light, and phosphorylated neurofilament heavy, remained near baseline.&lt;/p&gt;

&lt;p&gt;LUMINA (NCT06665165) is a multinational, randomized, double-blind, placebo-controlled, multiple ascending dose trial evaluating AMX0114 across four dose levels. The trial is expected</description>
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   <pubDate>Tue, 23 Jun 2026 07:00:26 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
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   <title>Amylyx ALS drug shows no serious adverse events in Phase 1 trial</title>
   <link>http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</link>
   <description>

&lt;p&gt;Amylyx Pharmaceuticals (NASDAQ: AMLX) presented early data from the Phase 1 LUMINA trial of its investigational drug AMX0114 for amyotrophic lateral sclerosis (ALS) at the European Network to Cure ALS (ENCALS) Meeting 2026 in Madrid, Spain.&lt;/p&gt;

&lt;p&gt;In Cohort 1, which evaluated the lowest dose level of 12.5 mg in 12 participants, AMX0114 showed no drug-related serious adverse events and no serious neurological adverse events. Biomarker levels, including spectrin breakdown product 145, neurofilament light, and phosphorylated neurofilament heavy, remained near baseline.&lt;/p&gt;

&lt;p&gt;LUMINA (NCT06665165) is a multinational, randomized, double-blind, placebo-controlled, multiple ascending dose trial evaluating AMX0114 across four dose levels. The trial is expected</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</guid>
   <pubDate>Tue, 23 Jun 2026 07:00:26 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
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   <title>Amylyx ALS drug shows no serious adverse events in Phase 1 trial</title>
   <link>http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</link>
   <description>

&lt;p&gt;Amylyx Pharmaceuticals (NASDAQ: AMLX) presented early data from the Phase 1 LUMINA trial of its investigational drug AMX0114 for amyotrophic lateral sclerosis (ALS) at the European Network to Cure ALS (ENCALS) Meeting 2026 in Madrid, Spain.&lt;/p&gt;

&lt;p&gt;In Cohort 1, which evaluated the lowest dose level of 12.5 mg in 12 participants, AMX0114 showed no drug-related serious adverse events and no serious neurological adverse events. Biomarker levels, including spectrin breakdown product 145, neurofilament light, and phosphorylated neurofilament heavy, remained near baseline.&lt;/p&gt;

&lt;p&gt;LUMINA (NCT06665165) is a multinational, randomized, double-blind, placebo-controlled, multiple ascending dose trial evaluating AMX0114 across four dose levels. The trial is expected</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Amylyx+ALS+drug+shows+no+serious+adverse+events+in+Phase+1+trial/26675676.html</guid>
   <pubDate>Tue, 23 Jun 2026 07:00:26 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</guid>
   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
   	  </item>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</guid>
   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
   	  </item>
  <item>
   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</guid>
   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.30945667</category>
   	  </item>
  <item>
   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Press+Releases/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
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   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">AMLX</category>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Business+Wire/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
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&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
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   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Business+Wire/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
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&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
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   <pubDate>Tue, 23 Jun 2026 07:00:00 -0400</pubDate>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Business+Wire/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
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   <title>Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026</title>
   <link>http://www.streetinsider.com/Business+Wire/Amylyx+Pharmaceuticals+to+Present+Data+from+First-in-Human%2C+Dose-Ranging+Phase+1+LUMINA+Trial+of+AMX0114+in+ALS+at+ENCALS+2026/26675654.html</link>
   <description>
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fwww.amylyx.com%2F&amp;amp;esheet=54558192&amp;amp;newsitemid=20260623249003&amp;amp;lan=en-US&amp;amp;anchor=Amylyx+Pharmaceuticals%2C+Inc.&amp;amp;index=1&amp;amp;md5=240cc5fdc1eaa4c48aa000f98e53032d&quot; shape=&quot;rect&quot;&gt;Amylyx Pharmaceuticals, Inc.&lt;/a&gt; (NASDAQ: AMLX) (“Amylyx” or the “Company”) today announced the presentation of data from its first-in-human, dose-ranging Phase 1 LUMINA trial of AMX0114 at the European Network to Cure ALS (ENCALS) Meeting 2026, held from June 24-26, 2026 in Madrid, Spain.

&lt;/p&gt;&lt;p&gt;
AMX0114 showed no drug-related serious adverse events (SAEs) and no serious neurological adverse events (AEs) in Cohort 1 (lowest dose level 12.5 mg). These safety findings support continued evaluation of AMX0114 at higher dose levels in this multiple ascending dose trial. Biomarker levels, including spectrin breakdown product 145</description>
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