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   <title>Astellas begins Phase 3 trial of ASP2138 for gastric cancer</title>
   <link>http://www.streetinsider.com/FDA/Astellas+begins+Phase+3+trial+of+ASP2138+for+gastric+cancer/26969496.html</link>
   <description>

&lt;p&gt;Astellas Pharma Inc. (TSE: 4503) announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138, an investigational bispecific antibody, in combination with chemotherapy and pembrolizumab as a first-line treatment for adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are CLDN18.2-positive and HER2-negative.&lt;/p&gt;

&lt;p&gt;ASP2138 is administered subcutaneously and is designed to bind to CLDN18.2, a protein expressed on certain tumor cells, and CD3-positive T cells. The mechanism is intended to bring T cells closer to CLDN18.2-expressing tumor cells to activate an anti-tumor response.&lt;/p&gt;

&lt;p&gt;The Phase 3 study is a randomized, double-blind,</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:22 -0400</pubDate>
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   <title>Astellas begins Phase 3 trial of ASP2138 for gastric cancer</title>
   <link>http://www.streetinsider.com/FDA/Astellas+begins+Phase+3+trial+of+ASP2138+for+gastric+cancer/26969496.html</link>
   <description>

&lt;p&gt;Astellas Pharma Inc. (TSE: 4503) announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138, an investigational bispecific antibody, in combination with chemotherapy and pembrolizumab as a first-line treatment for adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are CLDN18.2-positive and HER2-negative.&lt;/p&gt;

&lt;p&gt;ASP2138 is administered subcutaneously and is designed to bind to CLDN18.2, a protein expressed on certain tumor cells, and CD3-positive T cells. The mechanism is intended to bring T cells closer to CLDN18.2-expressing tumor cells to activate an anti-tumor response.&lt;/p&gt;

&lt;p&gt;The Phase 3 study is a randomized, double-blind,</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:22 -0400</pubDate>
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   <title>Astellas begins Phase 3 trial of ASP2138 for gastric cancer</title>
   <link>http://www.streetinsider.com/FDA/Astellas+begins+Phase+3+trial+of+ASP2138+for+gastric+cancer/26969496.html</link>
   <description>

&lt;p&gt;Astellas Pharma Inc. (TSE: 4503) announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138, an investigational bispecific antibody, in combination with chemotherapy and pembrolizumab as a first-line treatment for adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors are CLDN18.2-positive and HER2-negative.&lt;/p&gt;

&lt;p&gt;ASP2138 is administered subcutaneously and is designed to bind to CLDN18.2, a protein expressed on certain tumor cells, and CD3-positive T cells. The mechanism is intended to bring T cells closer to CLDN18.2-expressing tumor cells to activate an anti-tumor response.&lt;/p&gt;

&lt;p&gt;The Phase 3 study is a randomized, double-blind,</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Astellas+begins+Phase+3+trial+of+ASP2138+for+gastric+cancer/26969496.html</guid>
   <pubDate>Mon, 24 Aug 2026 19:30:22 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/PRNewswire/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
   <description>
&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/PRNewswire/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
   <link>http://www.streetinsider.com/PRNewswire/Astellas+Doses+First+Patient+in+Phase+3+Study+of+ASP2138+in+CLDN18.2-postive+and+HER2-negative+locally+advanced+unresectable+or+metastatic+gastric+or+gastroesophageal+junction+%28GEJ%29+adenocarcinoma/26969495.html</link>
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&lt;div class=&quot;xn-content&quot;&gt;
&lt;p class=&quot;prntac&quot;&gt;-&lt;i&gt; ASP2138's advancement into Phase &lt;money&gt;3 marks&lt;/money&gt; an important milestone in Astellas' commitment to advancing research in CLDN18.2 with its differentiated portfolio, spanning approved treatments and investigational assets -&lt;/i&gt; &lt;/p&gt;&lt;p&gt;&lt;span class=&quot;legendSpanClass&quot;&gt;&lt;location value=&quot;LU/jp..tokyo&quot; idsrc=&quot;xmltag.org&quot; &gt;TOKYO&lt;/location&gt;&lt;/span&gt;, &lt;span class=&quot;legendSpanClass&quot;&gt;&lt;chron&gt;Aug. 24, 2026&lt;/chron&gt;&lt;/span&gt; /PRNewswire/ -- &lt;span value=&quot;Tokyo:4503&quot; idsrc=&quot;xmltag.org&quot; &gt;Astellas Pharma Inc.&lt;/span&gt; (TSE: 4503, President and CEO: &lt;person&gt;Naoki Okamura&lt;/person&gt;, &quot;Astellas&quot;) today announced that the first patient has been dosed in a Phase 3 study evaluating ASP2138 in combination with chemotherapy and pembrolizumab as first-line treatment in adults with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma, whose tumors are Claudin 18.2 (CLDN18.2)-positive</description>
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   <title>Astellas Doses First Patient in Phase 3 Study of ASP2138 in CLDN18.2-postive and HER2-negative locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma</title>
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   <pubDate>Mon, 24 Aug 2026 19:30:00 -0400</pubDate>
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