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Form 4 Alector, Inc. For: Jul 09 Filed by: Wong-Sarad Grace

Thu, 09 Jul 2026 16:05:00 -0400

si-local-file:///var/storage/secattach/20260709/26753226.html

Form 4 Alector, Inc. For: Jul 09 Filed by: Wong-Sarad Grace

Thu, 09 Jul 2026 16:05:00 -0400

si-local-file:///var/storage/secattach/20260709/26753226.html

GSK terminates collaboration with Alector after trial failures

Wed, 08 Jul 2026 16:13:44 -0400

Alector Inc. (NASDAQ: ALEC) disclosed that GlaxoSmithKline unit Glaxo Wellcome UK Limited has moved to terminate its collaboration and license agreement with the company, following the failure of two clinical trials.

GSK provided written notice of termination on July 6, 2026. Under the agreement's terms, the termination becomes effective 180 days from that notice, on January 2, 2027.

The termination follows two clinical setbacks. In October 2025, Alector's Phase 3 INFRONT-3 trial evaluating latozinemab in patients with frontotemporal dementia due to a progranulin gene mutation failed to meet its co-primary clinical endpoint. In April 2026, the company discontinued its Phase 2 PROGRESS-AD

GSK terminates collaboration with Alector after trial failures

Wed, 08 Jul 2026 16:13:44 -0400

GSK provided written notice of termination on July 6, 2026. Under the agreement's terms, the termination becomes effective 180 days from that notice, on January 2, 2027.

Form 8-K Alector, Inc. For: Jul 06

Wed, 08 Jul 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260708/26747589.html

Form 8-K Alector, Inc. For: Jul 06

Wed, 08 Jul 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260708/26747589.html

Form 4 Alector, Inc. For: Jun 17 Filed by: Hammond Paula

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659837.html

Form 4 Alector, Inc. For: Jun 17 Filed by: Hammond Paula

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659837.html

Form 4 Alector, Inc. For: Jun 17 Filed by: Yaffe Kristine

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659841.html

Form 4 Alector, Inc. For: Jun 17 Filed by: Yaffe Kristine

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659841.html

Form 4 Alector, Inc. For: Jun 17 Filed by: SCHELLER RICHARD H

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659842.html

Form 4 Alector, Inc. For: Jun 17 Filed by: SCHELLER RICHARD H

Wed, 17 Jun 2026 16:06:00 -0400

si-local-file:///var/storage/secattach/20260617/26659842.html

Form 4 Alector, Inc. For: Jun 17 Filed by: DESOUZA ERROL B