Nvidia (NASDAQ: NVDA) and the University of Washington Medicine Institute for Protein Design have released RFD4-Proteina, an open model that combines programmable protein design with search capabilities, according to a company press release issued at GTC Berlin on Oct. 21, 2026.

The model generates targeted protein designs and allows scientists to search and refine candidates using molecular inputs, constraints and scoring objectives. In testing, RFD4-Proteina achieved higher computational design success rates and generation throughput than evaluated baselines across four benchmark categories: protein binding, small-molecule binding, enzyme scaffolding and DNA binding.

"We are moving from an era of discovering the proteins nature has made to one in which we can design entirely new ones," said David Baker, 2024 Nobel Laureate in chemistry and director of the Institute for Protein Design at the University of Washington. "RFD4-Proteina expands what scientists can create, from proteins that could advance drug discovery to enzymes that break down pesticides."

The model is available through partners including Amazon Bio Discovery, Anthropic's Claude Science, Benchling, Databricks, Google Cloud, Hugging Face, Nebius, OpenAI and Tamarind Bio.

Separately, Siemens Healthineers is collaborating with Nvidia to develop adaptive radiotherapy tools using Nvidia Nemotron models for agentic co-planning, CUDA-accelerated dose calculation and the Nvidia Holoscan platform for real-time sensor integration.

Several life sciences companies are also building on Nvidia's BioNeMo open platform to develop scientific agents that connect drug design and laboratory workflows. These include Automata, Benchling, Biolevate, Boltz, Danaher, Hologen and Therna Biosciences.

On the hospital operations side, companies including Avelios, Corti, Dedalus, Dawn Health and Sword are building on Nvidia Nemotron for clinical workflow tools. PolyAI is using Nvidia Agent Toolkit for multilingual dialog with medical software provider Corilus, which serves more than 70,000 healthcare professionals across Belgium and France. Apian and VitVio are using Nvidia Cosmos and Nvidia Omniverse to build digital twins for hospital operations monitoring.