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GeneDx Reports First Quarter 2026 Financial Results and Updates Full-Year Outlook

May 4, 2026 4:05 PM

GAITHERSBURG, Md.--(BUSINESS WIRE)-- GeneDx Holdings Corp. (Nasdaq: WGS), the leader in rare disease diagnosis and improving health through the power of genomic data, today reported its financial results for the first quarter of 2026.

“GeneDx delivered 34% year-over-year volume growth in exome and genome testing in the first quarter – a clear signal that there’s sustained, strong demand for our services. While our revenue did not reflect the full potential of what this business is capable of, we are adjusting our outlook and are poised to deliver more than 30% volume growth, 70% gross margin, and profitability on an adjusted basis for the year,” said Katherine Stueland, CEO of GeneDx. “Leading a generational shift in medicine requires taking some big swings, learning quickly, and moving with urgency to serve this ever-growing patient population. With expectations reset, we’ve never been more confident about our ability to deliver profitable growth in service of patients and shareholders.”

First Quarter 2026 Financial Results (Unaudited)(1)

Revenue

Exome and genome volume

Gross margin

Operating expenses

Net (loss) income

Cash position

(1)

Adjusted gross margin, adjusted total operating expenses and adjusted net (loss) income are non-GAAP financial measures. See appendix for a reconciliation of GAAP to non-GAAP figures presented.

Updated 2026 Guidance

GeneDx has updated its 2026 guidance. Management now expects GeneDx to deliver:

Metric

Full Year 2026

Previous Guidance

Full Year 2026

Updated Guidance

Second Quarter of 2026 Guidance

Revenue

$540 to $555 million

$475 to $490 million

$110 to $112 million

Growth in exome and genome volume

33% to 35%

At least 30%

Approximately 30,000 tests

Growth in exome and genome revenue

33% to 35%

At least 20%

Approximately $100 million

Adjusted gross margin

At least 70%

Approximately 70%

Approximately 70%

Adjusted net income (loss)

Positive

Positive

Adj. net loss of approximately $5 million

First Quarter 2026 and Recent Business Highlights

Strategic Expansion and Market Leadership

Innovation & Clinical Leadership

Webcast and Conference Call Details

GeneDx will host a conference call today, May 4, 2026, at 4:30 p.m. Eastern Time. Investors interested in listening to the conference call are required to register online. A live and archived webcast of the event will be available on the “Events” section of the GeneDx investor relations website at https://ir.genedx.com/.

Non-GAAP Financial Measures

GeneDx believes non-GAAP measures are useful in evaluating its operating performance. GeneDx uses this supplemental information to evaluate its ongoing operations and for internal planning and forecasting purposes. GeneDx believes that non-GAAP financial information, when taken collectively with its GAAP financial information, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool, and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP. Reconciliations of non-GAAP financial measures to the most directly comparable financial results as determined in accordance with GAAP are included at the end of this press release following the accompanying financial data. We define non-GAAP financial measures as GAAP measures, excluding certain items such as stock-based compensation expense, depreciation and amortization, restructuring costs, changes in the fair value of financial liabilities, non-core lease costs, and other expenses that the Company believes are not indicative of its ongoing operations. A reconciliation of non-GAAP guidance measures to corresponding GAAP measures is not available on a forward-looking basis without unreasonable effort due to the uncertainty of expenses that may be incurred in the future. Investors are encouraged to review the related GAAP financial measures and the reconciliation of these non-GAAP financial measures to their most directly comparable GAAP financial measures and not rely on any single financial measure to evaluate our business.

Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995, including statements regarding our future performance and our market opportunity, including our expectations for full year and second quarter 2026 revenue, exome and genome revenue and test volumes, adjusted gross margin and adjusted net income (loss). These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) our ability to implement business plans, goals and forecasts, and identify and realize additional opportunities, (ii) the risk of downturns and a changing regulatory landscape in the highly competitive healthcare industry, (iii) the size and growth of the market in which we operate, and (iv) recalibrating for building long-term, durable performance. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the U.S. Securities and Exchange Commission (the “SEC”) on February 23, 2026, our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2026, filed with the SEC on May 4, 2026 and other documents filed by us from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and we assume no obligation and do not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. We do not give any assurance that we will achieve our expectations.

About GeneDx

GeneDx’s (Nasdaq: WGS) mission is to empower everyone to live their healthiest life through genomics. GeneDx combines unmatched clinical expertise, advanced technology, and the power of GeneDx Infinity™ – the world’s largest rare disease genomic dataset. This unparalleled foundation powers GeneDx’s ExomeDx™ and GenomeDx™ tests – ranked #1 by expert geneticists and granted FDA Breakthrough Device designation – enabling clinicians to deliver precise, fast, and actionable diagnoses. GeneDx Infinity also fuels discovery for biopharma, with the most powerful AI-driven genomic intelligence. A genomics pioneer over the last 25 years, diagnosing more than 4,800 genetic diseases and publishing more than 1,100 research publications, GeneDx is building the network that will drive the future of genomic precision medicine. For more information, visit genedx.com and connect with us on LinkedIn, Facebook, and Instagram.

Volume & Revenue

1Q26

4Q25

3Q25

2Q25

1Q25

Volumes

Whole exome, whole genome

27,488

27,761

25,702

23,246

20,562

Hereditary cancer

108

346

1,511

2,677

2,725

Other panels

27,621

30,935

33,003

31,833

28,228

Total

55,217

59,042

60,216

57,756

51,515

Revenue ($ millions)

Whole exome, whole genome

$

90.6

$

104.0

$

98.9

$

86.0

$

71.4

Hereditary cancer

0.1

0.2

1.2

1.8

2.2

Other panels

10.6

13.1

13.4

12.3

12.1

Data information

0.8

2.6

1.5

2.0

1.4

Software and interpretation services

0.2

1.1

1.7

0.6

Total

$

102.3

$

121.0

$

116.7

$

102.7

$

87.1

Unaudited Select Financial Information (in thousands)

Three months ended March 31, 2026

Three months ended March 31, 2025

GeneDx

Other(1)

Total

GeneDx

Other(1)

Total

Revenue

$101,496

$758

$102,254

$87,115

$—

$87,115

Adjusted cost of services

31,613

588

32,201

27,396

27,396

Adjusted gross profit

$69,883

$170

$70,053

$59,719

$—

$59,719

Adjusted gross margin %

68.9%

68.5%

68.6%

68.6%

(1)

For the three months ended March 31, 2026, Other represents revenues and cost of services from the Fabric Genomics operating segment. For the three months ended March 31, 2025, Other represents revenues and cost of services from the Legacy Sema4 diagnostic testing business.

Three months ended March 31, 2026

Reported

Depreciation and amortization

Stock-based compensation

Restructuring costs

Change in FV of financial liabilities

Extinguishment of debt

Other(2)

Adjusted

Diagnostic test revenue

$

101,299

$

$

$

$

$

$

$

101,299

Other revenue

955

955

Total revenue

102,254

102,254

Cost of services

34,043

(1,462

)

(380

)

32,201

Gross profit

68,211

1,462

380

70,053

Gross margin

66.7

%

68.5

%

Research and development

19,804

(224

)

(1,406

)

(224

)

17,950

Selling, general and administrative

74,591

(5,123

)

(7,210

)

(215

)

(1,916

)

60,127

Impairment loss

31,287

(31,287

)

Loss from operations

(57,471

)

6,809

8,996

439

33,203

(8,024

)

Interest expense, net

(717

)

717

Other (expense) income, net

(4,231

)

(2,540

)

6,565

(206

)

Income tax expense

(897

)

897

Net loss

$

(63,316

)

$

6,809

$

8,996

$

439

$

(2,540

)

$

6,565

$

34,817

$

(8,230

)

Basic and diluted loss per share(1)

$

(2.16

)

$

(0.28

)

Three months ended March 31, 2025

Reported

Depreciation and amortization

Stock-based compensation

Restructuring costs

Change in FV of financial liabilities

Other(2)

Adjusted

Diagnostic test revenue

$

85,759

$

$

$

$

$

85,759

Other revenue

1,356

1,356

Total revenue

87,115

87,115

Cost of services

28,639

(1,075

)

(168

)

27,396

Gross profit

58,476

1,075

168

59,719

Gross margin

67.1

%

68.6

%

Research and development

12,577

(372

)

(419

)

(28

)

11,758

Selling, general and administrative

50,450

(4,231

)

(3,396

)

(530

)

(3,265

)

39,028

(Loss) income from operations

(4,551

)

5,678

3,983

558

3,265

8,933

Interest expense, net

(640

)

640

Other (expense) income, net

(891

)

1,100

30

239

Income tax expense

(447

)

447

Net (loss) income

$

(6,529

)

$

5,678

$

3,983

$

558

$

1,100

$

4,382

$

9,172

Basic (loss) earnings per share(1)

$

(0.23

)

$

0.33

Diluted (loss) earnings per share(1)

$

(0.23

)

$

0.31

(1)

Basic and diluted (loss) earnings per share are calculated based on 29,335,126 weighted average shares outstanding for the three months ended March 31, 2026, and 28,147,948 and 29,440,704 weighted average shares outstanding for the three months ended March 31, 2025, respectively.

(2)

Other represents interest expense, net, income tax expense and non-core lease costs for all periods presented. For the three months ended March 31, 2026, Other also includes costs related to legal reserves and impairment of goodwill and intangible assets associated with the Fabric Genomics acquisition. For the three months ended March 31, 2025, Other includes transaction costs incurred in connection with the acquisition of Fabric Genomics.

GeneDx Holdings Corp.

Condensed Consolidated Balance Sheets

(in thousands, except share and per share amounts)

March 31, 2026 (Unaudited)

December 31, 2025

Assets:

Current assets:

Cash and cash equivalents

$

93,924

$

104,997

Marketable securities

76,761

66,285

Accounts receivable

76,929

74,370

Inventory, net

12,241

13,951

Prepaid expenses and other current assets

10,774

8,685

Total current assets

270,629

268,288

Operating lease right-of-use assets

34,653

23,412

Property and equipment, net

50,125

45,693

Goodwill

1,641

13,520

Intangible assets, net

144,969

168,481

Other assets(1)

4,284

4,316

Total assets

$

506,301

$

523,710

Liabilities and Stockholders’ Equity:

Current liabilities:

Accounts payable and accrued expenses

$

46,562

$

57,645

Short-term lease liabilities

5,129

4,404

Other current liabilities

35,948

46,859

Total current liabilities

87,639

108,908

Long-term debt, net of current portion

96,732

48,176

Long-term lease liabilities

66,331

56,046

Other liabilities

71

1,641

Deferred taxes

1,404

757

Total liabilities

252,177

215,528

Stockholders’ Equity:

Preferred stock

Class A common stock

3

3

Additional paid-in capital

1,690,249

1,680,738

Accumulated deficit

(1,436,811

)

(1,373,495

)

Accumulated other comprehensive income

683

936

Total stockholders’ equity

254,124

308,182

Total liabilities and stockholders’ equity

$

506,301

$

523,710

(1)

Other assets includes $1.0 million of restricted cash as of both March 31, 2026 and December 31, 2025.

GeneDx Holdings Corp.

Condensed Consolidated Statements of Operations (Unaudited)

(in thousands, except share and per share amounts)

Three months ended March 31,

2026

2025

Revenue

Diagnostic test revenue

$

101,299

$

85,759

Other revenue

955

1,356

Total revenue

102,254

87,115

Cost of services

34,043

28,639

Gross profit

68,211

58,476

Research and development

19,804

12,577

Selling, general and administrative

74,591

50,450

Impairment loss

31,287

Loss from operations

(57,471

)

(4,551

)

Non-operating (expenses) income, net

Change in fair value of financial liabilities

2,540

(1,100

)

Interest expense, net

(717

)

(640

)

Loss on extinguishment of debt

(6,565

)

Other (expense) income, net

(206

)

209

Total non-operating expense, net

(4,948

)

(1,531

)

Loss before income taxes

(62,419

)

(6,082

)

Income tax expense

(897

)

(447

)

Net loss

$

(63,316

)

$

(6,529

)

Weighted-average shares outstanding of Class A common stock

29,335,126

28,147,948

Basic and diluted loss per share, Class A common stock

$

(2.16

)

$

(0.23

)

GeneDx Holdings Corp.

Condensed Consolidated Statements of Cash Flows (Unaudited)

(in thousands)

Three months ended March 31,

2026

2025

Operating activities

Net loss

$

(63,316

)

$

(6,529

)

Adjustments to reconcile net loss to net cash (used in) provided by operating activities:

Depreciation and amortization expense

6,809

5,678

Stock-based compensation expense

8,996

3,983

Change in fair value of financial liabilities

(2,540

)

1,100

Deferred tax expense

897

447

Change in third party payor reserves

1,022

1,395

Loss on extinguishment of debt

6,565

Impairment loss

31,287

Other

1,034

757

Change in operating assets and liabilities:

Accounts receivable

(2,558

)

(8,557

)

Inventory

1,689

(2,032

)

Accounts payable and accrued expenses

(13,168

)

10,824

Other assets and liabilities

(9,125

)

3,116

Net cash (used in) provided by operating activities

(32,408

)

10,182

Investing activities

Purchases of marketable securities

(20,177

)

(17,209

)

Proceeds from sales of marketable securities

875

Proceeds from maturities of marketable securities

8,500

13,930

Purchases of property and equipment and development of internal-use software

(6,453

)

(6,129

)

Net cash used in investing activities

(17,255

)

(9,408

)

Financing activities

Proceeds from long term debt, net of issuance costs

96,998

13,894

Proceeds from issuance of common stock from subscription agreements

476

Exercise of stock options

58

735

Repayment of long-term debt, including prepayment penalty - Perceptive

(54,000

)

Repayment and principal payments for long-term debt - DECD

(4,447

)

(300

)

Finance lease principal payments

(495

)

(611

)

Net cash provided by financing activities

38,590

13,718

Net (decrease) increase in cash, cash equivalents and restricted cash

(11,073

)

14,492

Cash, cash equivalents and restricted cash, at beginning of period

105,989

86,202

Cash, cash equivalents and restricted cash, at end of period (1)

$

94,916

$

100,694

Supplemental disclosures of cash flow information

Cash paid for interest

$

1,748

$

1,600

Cash paid for taxes

$

754

$

206

Lease liability from obtaining right-of-use asset

$

12,086

$

Purchases of property and equipment in accounts payable and accrued expenses

$

5,915

$

2,197

(1)

Cash, cash equivalents and restricted cash as of March 31, 2026 excludes marketable securities of $76.8 million.

Investor Relations Contact:

[email protected]



Media Contact:

[email protected]

Source: GeneDx

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