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Form 3 AC Immune SA For: Mar 18 Filed by: Pfeifer Andrea

March 18, 2026 12:20 PM
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
Pfeifer Andrea

(Last) (First) (Middle)
EPFL INNOVATION PARK, BUILDING B

(Street)
LAUSANNE 1015

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
03/18/2026
3. Issuer Name and Ticker or Trading Symbol
AC Immune SA [ ACIU ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Executive Officer
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Shares 3,840,288 (1)
D
Common Shares 14,000
I
By spouse
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Share Option (right to buy) (2) 07/01/2027 Common Shares 102,811 9.53 D
Share Option (right to buy) (2) 10/28/2028 Common Shares 132,075 8.51 D
Share Option (right to buy) (2) 06/27/2029 Common Shares 132,837 5.39 D
Share Option (right to buy) (2) 06/25/2030 Common Shares 174,251 6.95 D
Share Option (right to buy) (2) 06/24/2031 Common Shares 218,216 7.23 D
Share Option (right to buy) (2) 06/23/2032 Common Shares 172,500 3.15 D
Share Option (right to buy) (2) 12/31/2032 Common Shares 644,444 2.03 D
Explanation of Responses:
1. Includes 1,921,005 common shares underlying outstanding restricted share units.
2. The share option is fully vested.
Remarks:
Exhibit 24 - Power of Attorney
/s/ Matthias Maurer, attorney-in-fact for Andrea Pfeifer 03/18/2026
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

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